tert-Butyl 4-(6-((6-(1-butoxyvinyl)-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate

Product Name: tert-Butyl 4-(6-((6-(1-butoxyvinyl)-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate
CAS No.: 866084-31-3
Chemical Name: tert-Butyl 4-(6-((6-(1-butoxyvinyl)-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate
Synonyms: Palbociclib-017;Palbociclib INT;Palbociclib Impurity 73;tert-butyl 4-(6-(8-cyclopentyl-5-Methyl-7-oxo-6-(1-propoxyvi...;tert-butyl 4-(6-(8-cyclopentyl-5-Methyl-7-oxo-6-(1-propoxyvinyl)-7,8-dihydropyrido[2,3-d]pyriMidin-2;2-[[5-(4-Boc-1-piperazinyl)-2-pyridyl]amino]-8-cyclopentyl-5-methyl-6-(1-propoxyvinyl)pyrido[2,3-d]pyrimidin-7(8H)-one;tert-butyl 4-(6-(8-cyclopentyl-5-Methyl-7-oxo-6-(1-propoxyvinyl)-7,8-dihydropyrido[2,3-d]pyriMidin-2-ylaMino)pyridin-3-yl)piperazine-1-carboxylate;tert-butyl 4-(6-((6-(1-butoxyvinyl)-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate;tert-butyl 4-(6-(8-cyclopentyl-5-methyl-7-oxo-6(1-propoxyvinyl) -7,8-dihydropyrido[2,3-d]pyrimidin)-2-ylamino)pyridine-3-yl) piperazine-1-carboxylate;4-[6-[[6-(1-Butoxyvinyl)-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl]amino]pyridin-3-yl]piperazine-1-carboxylic acid tert-butyl ester
CBNumber: CB82624327
Molecular Formula: C33H45N7O4
Formula Weight: 603.75
MOL File: 866084-31-3.mol

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tert-Butyl 4-(6-((6-(1-butoxyvinyl)-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate Property

Boiling point:: 764.2±70.0 °C(Predicted)
Density: 1.224±0.06 g/cm3(Predicted)
storage temp.: 2-8°C(protect from light)
solubility: DMSO (Slightly, Heated. Sonicated), Methanol (Slightly, Sonicated)
pka: 5.24±0.10(Predicted)
form: Solid
color: Light Yellow
Stability:: Light Sensitive
InChIKey: SCWKOLRZBMGTNT-UHFFFAOYSA-N
SMILES: N1(C(OC(C)(C)C)=O)CCN(C2=CC=C(NC3=NC=C4C(C)=C(C(OCCCC)=C)C(=O)N(C5CCCC5)C4=N3)N=C2)CC1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B750192
Product name: tert-Butyl4-[6-[[6-(1-Butoxyethenyl)-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidin-2-yl]amino]-pyridin-3-yl]-piperazine-1-carboxylate
Packaging: 50mg
Price: $275
Updated: 2021/12/16

AK Scientific

Product number: 2970DF
Product name: Tert-butyl4-[6-[[6-(1-butoxyethenyl)-8-cyclopentyl-5-methyl-7-oxopyrido[2,3-d]pyrimidin-2-yl]amino]pyridin-3-yl]piperazine-1-carboxylate
Packaging: 100mg
Price: $147
Updated: 2021/12/16

Crysdot

Product number: CD11041189
Product name: tert-Butyl4-(6-((6-(1-butoxyvinyl)-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate
Purity: 97%
Packaging: 100mg
Price: $243
Updated: 2021/12/16

Alichem

Product number: 866084313
Product name: tert-Butyl4-(6-((6-(1-butoxyvinyl)-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate
Packaging: 100mg
Price: $264.6
Updated: 2021/12/16

Alichem

Product number: 866084313
Product name: tert-Butyl4-(6-((6-(1-butoxyvinyl)-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate
Packaging: 250mg
Price: $380.24
Updated: 2021/12/16

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tert-Butyl 4-(6-((6-(1-butoxyvinyl)-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate Chemical Properties,Usage,Production

Uses

tert-Butyl 4-[6-[[6-(1-Butoxyethenyl)-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidin-2-yl]amino]-pyridin-3-yl]-piperazine-1-carboxylate is an intermediate in the commercial development of palbociclib, a highly selective reversible inhibitor of cyclin-dependent kinases CDK 4/6, which is developed for the treatment of ER-positive and HER2-negative breast cancer.

Preparation

4-[6-(6-bromo-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydro-pyridino[2,3-d]pyridine-2-yl-amino)-pyridine-3-yl]-piperazine-1-carboxylic acid tert-butyl ester (9.8 g, 0.017 mol), DMF (140 ml), vinyl n-butyl ether (17 g,0.17 mol), K2CO3 (5.27 g, 0.041 mol), Pd2dba3 (1.6 g, 0.17 mmol) and DABCO (0.23 g, 2.04 mmol) were added to the reaction flask and then heated the mixture to 80 ~ 85 °C. Tert-butyl 4-(6-(8-cyclopentyl-5-Methyl-7-oxo-6-(1-propoxyvinyl)-7,8-dihydropyrido[2,3-d]pyriMidin-2-ylaMino)pyridin-3-yl)piperazine-1-carboxylate was obtained through purification.

tert-Butyl 4-(6-((6-(1-butoxyvinyl)-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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tert-Butyl 4-(6-((6-(1-butoxyvinyl)-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate Suppliers

China 157 India 3 United States 4 Global 164

Shanghai Haohong Pharmaceutical Co., Ltd.

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TIANJIN PHARMACN MEDICAL TECHNOLOGY CO.,LTD.

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Email: 188120342808@163.com
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Shanghai Boyle Chemical Co., Ltd.

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Adamas Reagent, Ltd.

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Beijing Isomersyn Technology CO;LTD

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Daicel Chiral Technologies (China)CO.,LTD

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SHANGHAI YINGRUI CHEMICAL TECHNOLOGY CO.,LTD.

Tel: 21-33585366 13311639313
Fax: +86-21-34979012
Email: sales@shyrchem.com
Country: China
ProdList: 806
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Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
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ShangHai Caerulum Pharma Discovery Co., Ltd.

Tel: 18149758185 18149758185
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ProdList: 3505
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Taizhou Tongxin Bio-Tech Co., Ltd

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Email: sales@allyrise.com
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View Lastest Price from tert-Butyl 4-(6-((6-(1-butoxyvinyl)-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate manufacturers

Shenzhen Nexcon Pharmatechs Ltd.

Product: tert-Butyl 4-(6-((6-(1-butoxyvinyl)-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate 866084-31-3
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 2000
Release date: 2025-07-09

Shanghai Joiny Pharmaceutical Co.,LTD

Product: tert-butyl 4-(6-(8-cyclopentyl-5-methyl-7-oxo-6(1-propoxyvinyl) -7,8-dihydropyrido[2,3-d]pyrimidin)-2-ylamino)pyridine-3-yl) piperazine-1-carboxylate 866084-31-3
Price: US $0.00/kg
Min. Order: 1kg
Purity: 96%
Supply Ability: 200KG
Release date: 2023-03-30

Shanghai Joiny Pharmaceutical Co.,LTD

Product: 4-[6-[[6-(1-Butoxyvinyl)-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl]amino]pyridin-3-yl]piperazine-1-carboxylic acid tert-butyl ester 866084-31-3
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 500kg
Release date: 2023-09-01

866084-31-3, tert-Butyl 4-(6-((6-(1-butoxyvinyl)-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylateRelated Search:

PalBociclib Impurity 22 Phosphine oxide, tris (2-methylphenyl)- Palbociclib-030 tert-butyl 4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate 1-Piperazinecarboxylic acid, 4-(2-aMino-3-pyridinyl)-, 1,1-diMethylethyl ester 5-(piperazin-1-yl)pyridin-2-aMine Palbociclib-012 6-broMo-2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one PD 0332991 HCl 5-bromo-4-chloro-N-cyclopentylpyrimidin-2-amine 6-broMo-8-cyclopentyl-5-Methyl-2-(5-(piperazin-1-yl)pyridin-2-ylaMino)pyrido[2,3-d]pyriMidin-7(8H)-one Palbociclib Vonoprazan FuMarate Paroxetine Vonoprazan fumarate Vonoprazan PD0332991 Isethionate tert-Butyl 4-(6-(6-bromo-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydro-pyrido(2,3-d)pyrimidin-2-ylamino)-pyridin-3-yl)-piperazine-1-carboxylate

Palbociclib Impurity 73

Palbociclib impurity 19/Tert-butyl 4-(6-((6-(1-butoxyvinyl)-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate

tert-butyl 4-(6-(8-cyclopentyl-5-Methyl-7-oxo-6-(1-propoxyvinyl)-7,8-dihydropyrido[2,3-d]pyriMidin-2-ylaMino)pyridin-3-yl)piperazine-1-carboxylate

Palbociclib INT

tert-butyl 4-(6-((6-(1-butoxyvinyl)-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate

4-[6-[[6-(1-Butoxyvinyl)-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl]amino]pyridin-3-yl]piperazine-1-carboxylic acid tert-butyl ester

tert-butyl 4-(6-(8-cyclopentyl-5-Methyl-7-oxo-6-(1-propoxyvinyl)-7,8-dihydropyrido[2,3-d]pyriMidin-2

Palbociclib-017

2-Methyl-2-propanyl 4-(6-{[8-cyclopentyl-5-methyl-7-oxo-6-(1-prop oxyvinyl)-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl]amino}-3-pyridin yl)-1-piperazinecarboxylate

1-Piperazinecarboxylic acid, 4-[6-[[6-(1-butoxyethenyl)-8-cyclopentyl-7,8-dihydro-5-methyl-7-oxopyrido[2,3-d]pyrimidin-2-yl]amino]-3-pyridinyl]-, 1,1-dimethylethyl ester

tert-butyl 4-(6-(8-cyclopentyl-5-Methyl-7-oxo-6-(1-propoxyvi...

tert-butyl 4-(6-(8-cyclopentyl-5-methyl-7-oxo-6(1-propoxyvinyl) -7,8-dihydropyrido[2,3-d]pyrimidin)-2-ylamino)pyridine-3-yl) piperazine-1-carboxylate

2-[[5-(4-Boc-1-piperazinyl)-2-pyridyl]amino]-8-cyclopentyl-5-methyl-6-(1-propoxyvinyl)pyrido[2,3-d]pyrimidin-7(8H)-one

2-methyl-2-propyl-4-(6-[(8-cyclopentyl-5-methyl-7-oxo-6-(1-butoxyvinyl)-7,8-dihydropyrido [2,3-d] pyrimidin-2-yl) amino]-3-pyridinyl) piperazine-1-carboxylic acid

866084-31-3

8660841-31-3

C33H45N7O4

Anticancer