6-broMo-8-cyclopentyl-5-Methyl-2-(5-(piperazin-1-yl)pyridin-2-ylaMino)pyrido[2,3-d]pyriMidin-7(8H)-one

Product Name: 6-broMo-8-cyclopentyl-5-Methyl-2-(5-(piperazin-1-yl)pyridin-2-ylaMino)pyrido[2,3-d]pyriMidin-7(8H)-one
CAS No.: 851067-56-6
Chemical Name: 6-broMo-8-cyclopentyl-5-Methyl-2-(5-(piperazin-1-yl)pyridin-2-ylaMino)pyrido[2,3-d]pyriMidin-7(8H)-one
Synonyms: Palbociclib C;Palbociclib-013;Palbociclib Impurity J HCl;Pipemidic acid impurity BPO;PALBOCICLIB IMPURITY F (OR) 6-DESACETYL-6- BROMO PALBOCICLIB;Palbociclib Deboc Bromo Impurity / 6-Desacetyl-6-Bromo Palbociclib;6-Bromo-8-cyclopentyl-5-methyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-8H-pyrido[2,3-d]pyrimidin-7-one;6-broMo-8-cyclopentyl-5-Methyl-2-(5-(piperazin-1-yl)pyridin-2-ylaMino)pyrido[2,3-d]pyriMidin-7(8H)-one;6-Bromo-8-cyclopentyl-5-methyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]-pyrido[2,3-d]pyrimidin-7(8H)-one;Pyrido[2,3-d]pyrimidin-7(8H)-one, 6-bromo-8-cyclopentyl-5-methyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]-
CBNumber: CB02627155
Molecular Formula: C22H26BrN7O
Formula Weight: 484.39
MOL File: 851067-56-6.mol

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6-broMo-8-cyclopentyl-5-Methyl-2-(5-(piperazin-1-yl)pyridin-2-ylaMino)pyrido[2,3-d]pyriMidin-7(8H)-one Property

Boiling point:: 682.2±65.0 °C(Predicted)
Density: 1.495±0.06 g/cm3(Predicted)
storage temp.: 2-8°C, protect from light
solubility: Aqueous Acid (Slightly), DMSO (Slightly, Heated), DMF (Slightly, Heated)
pka: 8.66±0.10(Predicted)
form: Solid
color: Off-White to Yellow
InChIKey: DZCHDINWDGTTBZ-UHFFFAOYSA-N
SMILES: C1(NC2=NC=C(N3CCNCC3)C=C2)=NC=C2C(C)=C(Br)C(=O)N(C3CCCC3)C2=N1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: D290638
Product name: 6-Desacetyl-6-BromoPalbociclib
Packaging: 100mg
Price: $560
Updated: 2021/12/16

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6-broMo-8-cyclopentyl-5-Methyl-2-(5-(piperazin-1-yl)pyridin-2-ylaMino)pyrido[2,3-d]pyriMidin-7(8H)-one Chemical Properties,Usage,Production

Uses

6-Desacetyl-6-Bromo Palbociclib is an impurity of Palbociclib (P139900),(also known as compound number PD-0332991) is an experimental drug for the treatment of breast cancer being developed by Pfizer. It is a selective inhibitor of the cyclin-dependent kinases CDK4 and CDK6.Also, it is derived from 6-Bromo-2-chloro-8-cyclopentyl-5-methylpyrido-[2,3-d]pyrimidin-7(8H)-one (B682195), which is used to prepare pyridino[2,3-d]pyrimidin-7(8H)-one derivatives as CDK4 and/or CDK6 inhibitors useful in the treatment of diseases.

6-broMo-8-cyclopentyl-5-Methyl-2-(5-(piperazin-1-yl)pyridin-2-ylaMino)pyrido[2,3-d]pyriMidin-7(8H)-one Preparation Products And Raw materials

Raw materials

Preparation Products

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6-broMo-8-cyclopentyl-5-Methyl-2-(5-(piperazin-1-yl)pyridin-2-ylaMino)pyrido[2,3-d]pyriMidin-7(8H)-one Suppliers

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Arizest(Shanghai)Pharmatech Co.,Ltd

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851067-56-6, 6-broMo-8-cyclopentyl-5-Methyl-2-(5-(piperazin-1-yl)pyridin-2-ylaMino)pyrido[2,3-d]pyriMidin-7(8H)-oneRelated Search:

Everolimus PLERIXAFOR Parecoxib Palbociclib Impurity 7 2-chloro-4-(cyclopentylamino)-5-pyrimidinyl ethanone Palbociclib Palbociclib Impurity 8 Exemestane PalBociclib Impurity 22 Pyrido[2,3-d]pyriMidin-7(8H)-one, 8-cyclopentyl-5-Methyl-2-[[5-(1-piperazinyl)-2-pyridinyl]aMino]- Phosphine oxide, tris (2-methylphenyl)- Palbociclib-030 tert-butyl 4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate 1-Piperazinecarboxylic acid, 4-(2-aMino-3-pyridinyl)-, 1,1-diMethylethyl ester 5-(piperazin-1-yl)pyridin-2-aMine Palbociclib-012 6-broMo-2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one PD 0332991 HCl

6-broMo-8-cyclopentyl-5-Methyl-2-(5-(piperazin-1-yl)pyridin-2-ylaMino)pyrido[2,3-d]pyriMidin-7(8H)-one

6-Bromo-8-cyclopentyl-5-methyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]-pyrido[2,3-d]pyrimidin-7(8H)-one

4-(6-((6-bromo-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate

6-Bromo-8-cyclopentyl-5-methyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-8H-pyrido[2,3-d]pyrimidin-7-one

Palbociclib-013

6-broMo-8-cyclopentyl-5-Methyl-2-(5-(piperazin-1-yl)pyridin-2-ylaMino)pyrido[2,3-d]pyriMidin-7(8H)-one6-broMo-8-cyclopentyl-5-Methyl-2-(5-(piperazin-1-yl)pyridin-2-ylaMino)pyrido[2,3-d]pyriMidin-7(8H)-one

Palbociclib impurity 16/6-broMo-8-cyclopentyl-5-Methyl-2-(5-(piperazin-1-yl)pyridin- 2-ylaMino)pyrido[2,3-d]pyriMidin-7(8H)-one

Pyrido[2,3-d]pyrimidin-7(8H)-one, 6-bromo-8-cyclopentyl-5-methyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]-

Palbociclib C

Palbociclib Deboc Bromo Impurity / 6-Desacetyl-6-Bromo Palbociclib

Pipemidic acid impurity BPO

PALBOCICLIB IMPURITY F (OR) 6-DESACETYL-6- BROMO PALBOCICLIB

Palbociclib Impurity J HCl

851067-56-6

C22H26BrN7O