Parecoxib

Product Name: Parecoxib
CAS No.: 198470-84-7
Chemical Name: Parecoxib
Synonyms: Vorth-P;Valus-P;SC 69124;Parocoxib;Paricoxib;Parecoxib D5;Paris yesterday;Parecoxib (free);Parecoxib USP/EP/BP;parecoxib free base
CBNumber: CB81515695
Molecular Formula: C19H18N2O4S
Formula Weight: 370.42
MOL File: 198470-84-7.mol

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Parecoxib Property

Melting point:: 148.9-151°
Density: 1.264
storage temp.: 2-8°C
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
pka: 5.08±0.10(Predicted)
color: White to off-white
BRN: 8640266
InChI: InChI=1S/C19H18N2O4S/c1-3-17(22)21-26(23,24)16-11-9-14(10-12-16)18-13(2)25-20-19(18)15-7-5-4-6-8-15/h4-12H,3H2,1-2H3,(H,21,22)
InChIKey: TZRHLKRLEZJVIJ-UHFFFAOYSA-N
SMILES: C(NS(C1=CC=C(C2=C(C)ON=C2C2=CC=CC=C2)C=C1)(=O)=O)(=O)CC

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Safety

Hazard Codes: Xn,N
Risk Statements: 63-48/22-51/53
Safety Statements: 36/37-61
WGK Germany: 3
RTECS: TX1478700

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H373May cause damage to organs through prolonged or repeated exposure

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 32152
Product name: Parecoxib
Purity: VETRANAL
Packaging: 25mg
Price: $208
Updated: 2022/05/15

TRC

Product number: P193245
Product name: Parecoxib
Packaging: 50mg
Price: $165
Updated: 2021/12/16

AK Scientific

Product number: J97024
Product name: Parecoxib
Packaging: 25mg
Price: $74
Updated: 2021/12/16

ChemScene

Product number: CS-1959
Product name: Parecoxib
Purity: 99.32%
Packaging: 25mg
Price: $84
Updated: 2021/12/16

ChemScene

Product number: CS-1959
Product name: Parecoxib
Purity: 99.32%
Packaging: 50mg
Price: $144
Updated: 2021/12/16

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Parecoxib Chemical Properties,Usage,Production

Uses

Anti-inflammatory; analgesic (cyclooxygenase COX-2 inhibitor).

Uses

Parecoxib is used in the combination with Telmisartan for the treatment of endometriosis. Parecoxib reduces hippocampal inflammation and improve short-term memory function through the inhibition of COX-2 expression in aged rats after splenectomy.

Definition

ChEBI: An N-acylsulfonamide resulting from the formal condensation of valdecoxib with propionic acid. It is a prodrug for valdecoxib.

Synthesis

123-62-6

181695-72-7

198470-84-7

General procedure for the synthesis of N-((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)propionamide from propionic anhydride and 4-(5-methyl-3-phenyl-1,2-oxazol-4-yl)benzenesulfonamide: 3.1 grams (10 mmol) of 4-(5-methyl-3-phenyl-1,2-oxazol-4-yl)benzenesulfonamide was mixed with 3.5 grams (35 mmol) of triethylamine and 2.6 g (20 mmol) propionic anhydride in 20 mL of chloromethane. After completion of the reaction, the reaction mixture was poured into water and extracted with dichloromethane. The extract was concentrated, dissolved in ethanol, crystallized 5 to 10 times, filtered and dried to give 3.4 g of N-((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)propionamide in 92.5% yield and 99.77% purity.

in vivo

Parecoxib (intraperitoneal injection; 2.5, 5.0 or 10?mg/kg; once a day; 21?days) does not affect locomotor activity in the elevated plus-maze test, and Parecoxib at 5 and 10?mg/kg shows higher levels of percentage of time spent in the open arms^[3].

Animal Model:	Naive adult male ICR mice, 15?weeks old and weighing 25-35?g^[3]
Dosage:	2.5, 5.0 or 10?mg/kg
Administration:	Intraperitoneal injection; 2.5, 5.0 or 10?mg/kg; once a day; 21?days
Result:	Exerted an anxiolytic-like effect in the elevated plus-maze test

IC 50

COX-2

References

[1] Patent: CN105859647, 2016, A. Location in patent: Paragraph 0048; 0049; 0050
[2] Patent: CN106008387, 2016, A. Location in patent: Paragraph 0020; 0048; 0049; 0050
[3] Patent: CN106008386, 2016, A. Location in patent: Paragraph 0021; 0056; 0057; 0058
[4] Journal of Medicinal Chemistry, 2000, vol. 43, # 9, p. 1661 - 1663
[5] Patent: CN106674142, 2017, A. Location in patent: Paragraph 0038-0048

Parecoxib Preparation Products And Raw materials

Raw materials

Preparation Products

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Parecoxib Suppliers

China 206 India 6 Japan 1 United Kingdom 2 United States 15 Global 230

Shandong Chuangye Pharmaceutical Technology Co., Ltd.

Tel: 13325129676
Email: 3610186177@qq.com
Country: China
ProdList: 22
Advantage: 58

Shandong Mingfeng Pharmaceutical and Technology Co. Ltd

Tel: -1345456643 15315114555
Fax: QQ:1345456643
Email: 1345456643@qq.com
Country: China
ProdList: 243
Advantage: 58

TIANJIN PHARMACN MEDICAL TECHNOLOGY CO.,LTD.

Tel: 022-60189726 18812034280
Fax: 86-22-60979672
Email: 188120342808@163.com
Country: China
ProdList: 142
Advantage: 61

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42934
Advantage: 64

Shanghai G&K Biomedical Scientific Inc.

Tel: 021-34502253 13391330186
Fax: +86-21-23027826
Email: info@gksci.com
Country: China
ProdList: 133
Advantage: 52

Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
Email: sales@meilune.com
Country: China
ProdList: 4747
Advantage: 58

ShangHai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847 13636370518
Fax: 021-55068248
Email: shyysw007@163.com
Country: China
ProdList: 4999
Advantage: 60

Xi'an Manareco New Materials Co., Ltd.

Tel: 029-68669089-8816
Fax: +86-29-68669073
Email: market@xarlm.com
Country: China
ProdList: 499
Advantage: 55

Tianjin Branch Chong pharmaceutical intermediates Co., Ltd.

Tel: 022-60116533 13207668525
Fax: 022-60979672
Email: saleskc@scipharmacn.com
Country: China
ProdList: 603
Advantage: 58

Beijing HuaMeiHuLiBiological Chemical

Tel: 010-56205725
Fax: 010-65763397
Email: waley188@sohu.com
Country: China
ProdList: 12335
Advantage: 58

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View Lastest Price from Parecoxib manufacturers

Sinoway Industrial co., ltd.

Product: Parecoxib sodium 198470-84-7
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99% up, DMF
Supply Ability: 1ton
Release date: 2025-10-13

Hebei Chuanghai Biotechnology Co,.LTD

Product: Parecoxib 198470-84-7
Price: US $1.90/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 ton
Release date: 2024-08-15

Sigma Audley

Product: Parecoxib 198470-84-7
Price: US $35.00-25.00/kg
Min. Order: 1kg
Purity: 99.8%
Supply Ability: 200tons/year
Release date: 2024-03-15

198470-84-7, ParecoxibRelated Search:

Sorafenib Rivaroxaban FLURBIPROFEN AXETIL Celecoxib Lornoxicam Esomeprazole Atracurium besylate Dezocine 1-(2,6-Dichlorophenyl)-2-indolinone FENTANYL Ibuprofen Propofol Ketorolac tromethamine PARECOXIB SODIUM Nimesulide Parecoxib Valdecoxib PARECOXIB NA

Parecoxib (free)

N-[4-(5-methyl-3-phenyl-oxazol-4-yl)phenyl]sulfonylpropanamide

N-((4-(5-Methyl-3-phenyl-2,3-dihydrooxazol-4-yl)phenyl)sulfonyl)propionaMide

N-(4-(5-Methyl-3-phenylisoxazol-4-yl)phenylsulfonyl)propionaMide

Parecoxib SodiuM IMpurity W

Valdecoxib Impurity J

SC 69124

Valus-P

Vorth-P

Parocoxib

N-[[4-(5-Methyl-3-phenyl-4-isoxazolyl)phenyl]sulfonyl]propanamide

Parecoxib (This product is unavailable in the U.S.)

Parecoxib SodiuM iMpurity PR-12-I

Propanamide, N-[[4-(5-methyl-3-phenyl-4-isoxazolyl)phenyl]sulfonyl]-

Parecoxib USP/EP/BP

Parecoxib impurities

Parecoxib Sodium Impurity 81

parecoxib free base

Parecoxib (SC 69124)

Parecoxib D5

Paris yesterday

N-[4-(5-methyl-3-phenyl-1,2-oxazol-4-yl)benzenesulfonyl]propanamide

osteoarthritis,POCD,rheumatoid arthritis,pain,Cyclooxygenase,cognitive dysfunction,postoperative,Parecoxib,coxibs,analgesia,Inhibitor,inhibit,chronic inflammatory condition,SC69124,SC-69124,COX

Valdecoxib Impurity 38

Paricoxib

(3aR,4R,6S,6aS)-4-[[(1,1-Dimethylethoxy)carbonyl]amino]-3-(1-ethylpropyl)-3a,5,6,6a-tetrahydro-4H-cyclopent[d]isoxazole-6-carbox

N-{[4-(5-methyl-3-phenyl-1,2-oxazol-4-yl)phenyl]sulfonyl}propanamide

Parecoxib, 10 mM in DMSO

198470-84-7

Inhibitors

ZY