PARECOXIB SODIUM
- Product Name
- PARECOXIB SODIUM
- CAS No.
- 198470-85-8
- Chemical Name
- PARECOXIB SODIUM
- Synonyms
- Dynastat;Rayzon;SC 69124A;Parecoxib CRS;parexib sodium;Parecoxib-011-Na;Parecoxib sodium;Parecoxib sodiuM sal;Parecoxib sodiuM salt;Parecoxib Impurity 64
- CBNumber
- CB21003464
- Molecular Formula
- C19H19N2NaO4S
- Formula Weight
- 394.42
- MOL File
- 198470-85-8.mol
PARECOXIB SODIUM Property
- Melting point:
- 273-275°C
- storage temp.
- Inert atmosphere,2-8°C
- solubility
- DMF: 10mg/mL; DMSO: 15mg/mL; Ethanol: 3mg/mL; PBS (pH 7.2): 5mg/mL
- form
- Powder
- color
- White to off-white
- InChI
- InChI=1S/C19H18N2O4S.Na.H/c1-3-17(22)21-26(23,24)16-11-9-14(10-12-16)18-13(2)25-20-19(18)15-7-5-4-6-8-15;;/h4-12H,3H2,1-2H3,(H,21,22);;
- InChIKey
- OGSQVUBPCQXSGW-UHFFFAOYSA-N
- SMILES
- CC1ON=C(C2C=CC=CC=2)C=1C1C=CC(S(=O)(=O)NC(=O)CC)=CC=1.[NaH]
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H225Highly Flammable liquid and vapour
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 29017
- Product name
- Parecoxib (sodium salt)
- Packaging
- 10mg
- Price
- $62
- Updated
- 2024/03/01
- Product number
- 29017
- Product name
- Parecoxib (sodium salt)
- Packaging
- 25mg
- Price
- $113
- Updated
- 2024/03/01
- Product number
- 29017
- Product name
- Parecoxib (sodium salt)
- Packaging
- 50mg
- Price
- $211
- Updated
- 2024/03/01
- Product number
- 29017
- Product name
- Parecoxib (sodium salt)
- Packaging
- 100mg
- Price
- $357
- Updated
- 2024/03/01
- Product number
- P193275
- Product name
- ParecoxibSodium
- Packaging
- 100mg
- Price
- $995
- Updated
- 2021/12/16
PARECOXIB SODIUM Chemical Properties,Usage,Production
Description
Parecoxib is a prodrug form of the COX-2 inhibitor valdecoxib . It is converted to valdecoxib by human liver microsomes in vitro and in vivo in rats, dogs, and cynomolgous monkeys. Parecoxib is also a cannabinoid (CB) receptor 1 agonist with an EC50 value of 2.4 μM in HEK293 cells. It reduces hyperalgesia in a rat model of carrageenan-induced foot pad edema (ED50 = 5 mg/kg) and decreases inflammation in a rat model of M. butyricum-induced arthritis (ED50 = 0.08 mg/kg).
Chemical Properties
White Solid
Uses
Anti-inflammatory, analgesic.
Indications
For the short-term treatment of acute pain and post-operative pain i.e., oral surgery, abdominal hysterectomy, myomectomy, total knee replacement, total hip arthroplasty, laparoscopic cholecystectomy, inguinal hernia repair and other general surgery like diagnostic laparoscopy, gastrectomy, hernioplasty, appendectomy, hemithyroidectomy and splenectomy. Parecoxib Sodium may be used pre-operatively to prevent or reduce post-operative pain and it can reduce opioid requirements when they are used concomitantly.
Biological Functions
A water-soluble, injectable sodium salt form of parecoxib, an amide prodrug of the cyclooxygenase II (COX-2) selective, non-steroidal anti-inflammatory drug (NSAID) valdecoxib, with anti-inflammatory, analgesic, and antipyretic activities. Valdecoxib selectively binds to and inhibits COX-2. This prevents the conversion of arachidonic acid into prostaglandins, which are involved in the regulation of pain, inflammation, and fever. This NSAID does not inhibit COX-1 at therapeutic concentrations and, therefore, does not interfere with blood coagulation.
Pharmacokinetics
Parecoxib (Dynastat) is a prodrug of valdecoxib. Valdecoxib is an NSAID that exhibits antiinflammatory, analgesic and antipyretic properties in animal models. The mechanism of action is believed to be due to inhibition of prostaglandin synthesis primarily through inhibition of COX-2. At therapeutic plasma concentrations in humans valdecoxib does not inhibit cyclooxygenase-1 (COX-1).
PARECOXIB SODIUM Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from PARECOXIB SODIUM manufacturers
- Product
- Parecoxib Sodium 198470-85-8
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- More Than 99%
- Supply Ability
- 100kg/Month
- Release date
- 2024-09-20
- Product
- 198470-85-8 198470-85-8
- Price
- US $100.00-60.00/kg
- Min. Order
- 100kg
- Purity
- 99.99%
- Supply Ability
- 100Tons
- Release date
- 2023-03-17
- Product
- Parecoxib sodium 198470-85-8
- Price
- US $0.00-0.00/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 20 tons
- Release date
- 2024-04-07