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PARECOXIB SODIUM

Product Name
PARECOXIB SODIUM
CAS No.
198470-85-8
Chemical Name
PARECOXIB SODIUM
Synonyms
Dynastat;Rayzon;SC 69124A;Parecoxib CRS;parexib sodium;Parecoxib-011-Na;Parecoxib sodium;Parecoxib sodiuM sal;Parecoxib sodiuM salt;Parecoxib Impurity 64
CBNumber
CB21003464
Molecular Formula
C19H19N2NaO4S
Formula Weight
394.42
MOL File
198470-85-8.mol
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PARECOXIB SODIUM Property

Melting point:
273-275°C
storage temp. 
Inert atmosphere,2-8°C
solubility 
DMF: 10mg/mL; DMSO: 15mg/mL; Ethanol: 3mg/mL; PBS (pH 7.2): 5mg/mL
form 
Powder
InChI
InChI=1S/C19H18N2O4S.Na.H/c1-3-17(22)21-26(23,24)16-11-9-14(10-12-16)18-13(2)25-20-19(18)15-7-5-4-6-8-15;;/h4-12H,3H2,1-2H3,(H,21,22);;
InChIKey
OGSQVUBPCQXSGW-UHFFFAOYSA-N
SMILES
CC1ON=C(C2C=CC=CC=2)C=1C1C=CC(S(=O)(=O)NC(=O)CC)=CC=1.[NaH]
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H225Highly Flammable liquid and vapour

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
29017
Product name
Parecoxib (sodium salt)
Packaging
10mg
Price
$62
Updated
2024/03/01
Cayman Chemical
Product number
29017
Product name
Parecoxib (sodium salt)
Packaging
25mg
Price
$113
Updated
2024/03/01
Cayman Chemical
Product number
29017
Product name
Parecoxib (sodium salt)
Packaging
50mg
Price
$211
Updated
2024/03/01
Cayman Chemical
Product number
29017
Product name
Parecoxib (sodium salt)
Packaging
100mg
Price
$357
Updated
2024/03/01
TRC
Product number
P193275
Product name
ParecoxibSodium
Packaging
100mg
Price
$995
Updated
2021/12/16
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PARECOXIB SODIUM Chemical Properties,Usage,Production

Description

Parecoxib is a prodrug form of the COX-2 inhibitor valdecoxib . It is converted to valdecoxib by human liver microsomes in vitro and in vivo in rats, dogs, and cynomolgous monkeys. Parecoxib is also a cannabinoid (CB) receptor 1 agonist with an EC50 value of 2.4 μM in HEK293 cells. It reduces hyperalgesia in a rat model of carrageenan-induced foot pad edema (ED50 = 5 mg/kg) and decreases inflammation in a rat model of M. butyricum-induced arthritis (ED50 = 0.08 mg/kg).

Chemical Properties

White Solid

Uses

Anti-inflammatory, analgesic.

Indications

For the short-term treatment of acute pain and post-operative pain i.e., oral surgery, abdominal hysterectomy, myomectomy, total knee replacement, total hip arthroplasty, laparoscopic cholecystectomy, inguinal hernia repair and other general surgery like diagnostic laparoscopy, gastrectomy, hernioplasty, appendectomy, hemithyroidectomy and splenectomy. Parecoxib Sodium may be used pre-operatively to prevent or reduce post-operative pain and it can reduce opioid requirements when they are used concomitantly.

Biological Functions

A water-soluble, injectable sodium salt form of parecoxib, an amide prodrug of the cyclooxygenase II (COX-2) selective, non-steroidal anti-inflammatory drug (NSAID) valdecoxib, with anti-inflammatory, analgesic, and antipyretic activities. Valdecoxib selectively binds to and inhibits COX-2. This prevents the conversion of arachidonic acid into prostaglandins, which are involved in the regulation of pain, inflammation, and fever. This NSAID does not inhibit COX-1 at therapeutic concentrations and, therefore, does not interfere with blood coagulation.

Pharmacokinetics

Parecoxib (Dynastat) is a prodrug of valdecoxib. Valdecoxib is an NSAID that exhibits antiinflammatory, analgesic and antipyretic properties in animal models. The mechanism of action is believed to be due to inhibition of prostaglandin synthesis primarily through inhibition of COX-2. At therapeutic plasma concentrations in humans valdecoxib does not inhibit cyclooxygenase-1 (COX-1).

PARECOXIB SODIUM Preparation Products And Raw materials

Raw materials

Preparation Products

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PARECOXIB SODIUM Suppliers

Austria 1 Canada 1 China 348 Europe 2 Germany 1 Greece 1 India 23 Switzerland 1 United Kingdom 2 United States 18 Global 398
Chengdu Climb Pharmaceutical Technology Co., Ltd.
Tel
028-87608726 13540107218
Fax
028-87608725
Email
sales@cdclimb.com
Country
China
ProdList
104
Advantage
58
Nanjing Sunlida Biological Technology Co., Ltd.
Tel
025-57798810
Fax
025-57019371
Email
sales@sunlidabio.com
Country
China
ProdList
3750
Advantage
55
Shandong Chuangye Pharmaceutical Technology Co., Ltd.
Tel
13325129676
Email
3610186177@qq.com
Country
China
ProdList
21
Advantage
58
Hangzhou Benoy Chemical Co., Ltd.
Tel
17342059697
Fax
QQ:2710089141
Email
sales@benoychem.com
Country
China
ProdList
389
Advantage
58
Hubei huizepu Pharmaceutical Technology Co., Ltd
Tel
0185-0185-07139096 18507139096
Fax
QQ:1925957016
Email
18507139096@163.com
Country
China
ProdList
3855
Advantage
58
Bayee Biotech (Anqing) Co., Ltd.
Tel
0556-5032306 18917961636
Fax
+86-556-5032307
Email
wtx@bayeebio.com
Country
China
ProdList
304
Advantage
61
Jinzhou Kewei Biotechnology Co., Ltd
Tel
13932157273 13932157273
Email
1787461558@qq.com
Country
China
ProdList
17
Advantage
58
Shanghai?Medlife?Pharm-Tech?Co.,?Ltd
Tel
021-59167510 18117107507
Email
vip@med-life.cn
Country
China
ProdList
5019
Advantage
58
Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2923
Advantage
55
SiChuang NanBu Honesty Technology Co., Ltd.
Tel
0838-5675166 15883665058
Fax
0838-5675535
Email
nbcxkj@126.com
Country
China
ProdList
668
Advantage
55
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View Lastest Price from PARECOXIB SODIUM manufacturers

Hebei Dangtong Import and export Co LTD
Product
198470-85-8 198470-85-8
Price
US $100.00-60.00/kg
Min. Order
100kg
Purity
99.99%
Supply Ability
100Tons
Release date
2023-03-17
Ouhuang Engineering Materials (Hubei) Co., Ltd
Product
Parecoxib sodiuM 198470-85-8
Price
US $15.00/kg
Min. Order
1kg
Purity
99.912%
Supply Ability
10ton
Release date
2024-04-25
airuikechemical co., ltd.
Product
Parecoxib sodium 198470-85-8
Price
US $0.00-0.00/g
Min. Order
1g
Purity
99.9%
Supply Ability
20 tons
Release date
2024-04-07

198470-85-8, PARECOXIB SODIUMRelated Search:

N-((4-(5-Methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)isobutyraMide 5-Methyl-3-phenyl-4-(phenylMethyl)isoxazole Valdecoxib 3'-Sulfonyl Chloride IMpurity 5-METHYL-3,4-DIPHENYL-4,5-DIHYDROISOXAZOL-5-OL 3-(5-Methyl-3-phenylisoxazol-4-yl)benzenesulfonaMide 4-(4-chlorophenyl)-5-methyl-3-phenylisoxazole 2-Phenylacetophenone Valdecoxib IMpurity B Pantoprazole Sodium Paliperidone Z-Oxime 4-(3-methyl-4-phenylisoxazol-5-yl)benzenesulfonamide ethyl 4-(5-methyl-3-phenylisoxazol-4-yl)benzenesulfonate 5-Methyl-3,4-diphenylisoxazole DeoxyBenzoinOxime Valdecoxib 3'-SulfonaMide IMpurity Parecoxib Impurity H Parecoxib Valdecoxib

  • Parecoxib sodium （Intermediate in China ONLY）
  • N-[4-(5-METHYL-3-PHENYLISOXAZOL-4-YL)PHENYLSULFONYL]PROPIONAMIDE, SODIUM SALT
  • Parecoxib sodiuM salt
  • Dynastat
  • N-[[4-(5-Methyl-3-phenyl-4-isoxazolyl)phenyl]sulfonyl]propanaMide SodiuM Salt
  • Rayzon
  • SC 69124A
  • PropanaMide,N-[[4-(5-Methyl-3-phenyl-4-isoxazolyl)phenyl]sulfonyl]-, sodiuM salt (1:1)
  • Parecoxib sodiuM cloth
  • Parecoxib sodium N-[4-(5-Methyl-3-phenylisoxazol-4-yl)phenylsulfonyl]propionamide sodium salt
  • Parecoxib Sodium Impurity
  • Parecoxib sodiuM sal
  • sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide
  • Parecoxib-011-Na
  • Parecoxib Impurity 64
  • PARECOXIB SODIUM USP/EP/BP
  • sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonysodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl) (propionyl)amidel) (propionyl)amide
  • N-[[4-(5-Methyl-3-phenyl-4-isoxazolyl)phenyl]sulfonyl]propanamide Sodium Salt（Parecoxib Sodium）
  • N-[4-(5-methyl-3-phenyl-1,2-oxazol-4-yl)benzenesulfonyl]propanamide sodium hydride
  • Parecoxib sodium
  • Parecoxib Impurity 22 Sodium Salt
  • Parecoxib CRS
  • parexib sodium
  • Parecoxib Impurity 11 Sodium Salt
  • 198470-85-8
  • 198470-85-5
  • 98470-85-8
  • 10.98470-85-8
  • C19H17N2NaO4S
  • C19H17N2O4SNa
  • C19H18N2O4SNa
  • Aromatics
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • 198470-85-8