5-Methyl-3,4-diphenylisoxazole

Product Name: 5-Methyl-3,4-diphenylisoxazole
CAS No.: 37928-17-9
Chemical Name: 5-Methyl-3,4-diphenylisoxazole
Synonyms: 5-Methyl-3;CAS:37928-17-9;Parecoxib Sodium-4;5-Methyl-3,4-diphenyl;Parecoxib Related Compound;5-Methyl-3,4-diphenylisoxazole;3,4-Diphenyl-5-methylisoxazole;Parecoxib SodiuM interMediate A;Parecoxib SodiuM iMpurity PR-SM;Isoxazole, 5-Methyl-3,4-diphenyl-
CBNumber: CB52604537
Molecular Formula: C16H13NO
Formula Weight: 235.28
MOL File: 37928-17-9.mol

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5-Methyl-3,4-diphenylisoxazole Property

Melting point:: 96.0 to 100.0 °C
Boiling point:: 340.1±21.0 °C(Predicted)
Density: 1.108±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
form: Solid
pka: -2.53±0.50(Predicted)
color: White to Off-White
InChIKey: ZXIRUKJWLADSJS-UHFFFAOYSA-N

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Safety

HS Code: 2934.99.4400

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TCI Chemical

Product number: M2830
Product name: 5-Methyl-3,4-diphenylisoxazole
Purity: >98.0%(GC)
Packaging: 1g
Price: $36
Updated: 2024/03/01

TCI Chemical

Product number: M2830
Product name: 5-Methyl-3,4-diphenylisoxazole
Purity: >98.0%(GC)
Packaging: 5g
Price: $91
Updated: 2024/03/01

TRC

Product number: M312540
Product name: 5-Methyl-3,4-diphenylisoxazole
Packaging: 500mg
Price: $75
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0390904
Product name: 5-METHYL-3,4-DIPHENYLISOXAZOLE
Purity: 95.00%
Packaging: 5MG
Price: $497.88
Updated: 2021/12/16

AK Scientific

Product number: Y0376
Product name: 5-Methyl-3,4-diphenylisoxazole
Packaging: 25g
Price: $178
Updated: 2021/12/16

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5-Methyl-3,4-diphenylisoxazole Chemical Properties,Usage,Production

Uses

5-Methyl-3,4-diphenylisoxazole is synthesis The key intermediate of Parecoxib Sodium (Parecoxib Sodium).Parecoxib Sodium is by the Pfizer of the U.S. The cox 2 inhibitor of company's research and development, listed in European Union in 2002, trade name Dynastat, is used for The short term therapy of postoperative pain.

Uses

5-Methyl-3,4-diphenylisoxazole is a reagent for the preparation of valdecoxib and valdecoxib analogues.

Synthesis

In four mouthfuls of round-bottomed flasks of a 1L add compound 2 (40g), methanol (400mL), 7.7% Aqueous sodium carbonate (400mL), is heated to 70 DEG C, after stirring reaction 2h, and TLC plate monitoring raw material Fundamental reaction is complete, and solution is divided into solid-liquid biphase, is extracted with ethyl acetate, collected organic layer, with anhydrous Sodium sulfate is dried, and vacuum obtains white solid, HPLC purity: 94.9% after being spin-dried for.White solid uses 40ml ethyl acetate and the mixed solvent recrystallization of 120ml normal hexane (1:3) again, Obtaining target compound is white solid 34.2g, yield 92%, HPLC purity: 99.7%.m.p.97-98??￡? MS(m/z):236(M+H)+￡?1H NMR(400MHz,CDCl3) |?:2.43(s,3H,-CH3), 7.19-7.43 (m, 10H ,-CH=).

5-Methyl-3,4-diphenylisoxazole Preparation Products And Raw materials

Raw materials

Preparation Products

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5-Methyl-3,4-diphenylisoxazole Suppliers

Americas 1 China 279 Europe 1 India 9 Japan 1 Switzerland 1 United States 8 Global 300

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TCI (Shanghai) Development Co., Ltd.

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Jia Xing Isenchem Co.,Ltd

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Adamas Reagent, Ltd.

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View Lastest Price from 5-Methyl-3,4-diphenylisoxazole manufacturers

Hebei Dangtong Import and export Co LTD

Product: 5-Methyl-3,4-diphenylisoxazole 37928-17-9
Price: US $100.00-60.00/Grams
Min. Order: 100Grams
Purity: 99.99%
Supply Ability: 100Tons
Release date: 2023-03-06

Hebei Weibang Biotechnology Co., Ltd

Product: 5-Methyl-3,4-diphenylisoxazole 37928-17-9
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-11-04

Hebei Yanxi Chemical Co., Ltd.

Product: 5-Methyl-3,4-diphenylisoxazole 37928-17-9
Price: US $0.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 20tons
Release date: 2023-10-09

37928-17-9, 5-Methyl-3,4-diphenylisoxazoleRelated Search:

BenzenesulfonaMide, 3-[4-[4-(aMinosulfonyl)phenyl]-5-Methyl-3-isoxazolyl]- Valdecoxib IMpurity B Parecoxib 1-Hydroxy Valdecoxib Parecoxib Impurity 18 Valdecoxib 3'-Sulfonyl Chloride IMpurity 5-Methyl-3-phenyl-4-(phenylMethyl)isoxazole 4-(4-chlorophenyl)-5-methyl-3-phenylisoxazole N-((4-(5-Methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)acetaMide 4-[(5-Methyl-3-phenyl-4-isoxazolyl)methyl]benzenesulfonamide 2-Phenylacetophenone 3-methyl -4,5-diphenyl-4,5-didydro-isoxazole Valdecoxib IMpurity-E Valdecoxib Deoxybenzoin Oxime 5-METHYL-3,4-DIPHENYL-4,5-DIHYDROISOXAZOL-5-OL Valdecoxib IMpurity D PARECOXIB SODIUM

Valdecoxib Impurity 10 (Desulfonamide)

4-diphenyl-(Parecoxib sodiuM inteMediate)

5-Methyl-3

Parecoxib impurity 5/5-methyl-3,4-diphenylisoxazole

Isoxazole, 5-Methyl-3,4-diphenyl- (Parecoxib sodiuM inteMediate)

Isoxazole, 5-Methyl-3,4-diphenyl-

3,4-Diphenyl-5-methylisoxazole

5-Methyl-3,4-diphenylisoxazole

3-Phenyl-4-(4-aMinosulfonylbenzyl)-5-Methylisoxazole,Valdecoxib IMpurity A

Parecoxib SodiuM interMediate A

Parecoxib InterMediate (5-Mehyl-3,4-Diphenylisoxazole)

5-Methyl-3,4-diphenyl- (Parecoxib sodiuM inteMediate)

CAS:37928-17-9

Parecoxib SodiuM iMpurity PR-SM

Parecoxib Related Compound

Parecoxib Impurity 19 (Valdecoxib Impurity 10 (Desulfonamide))

Valdecoxib Impurity 10 (Desulfonamide) (Parecoxib Impurity 19)

Parecoxib Sodium-4

5-Methyl-3,4-diphenyl-1,2-oxazole

PARECOXIB SODIUM CAS 198470-85-8 INTERMEDIATES

Isoxazole, 5-Methyl-3,4-diphenyl- (Parecoxib sodiuM inteMediate) ISO 9001：2015 REACH

Parecoxib intermediates，5-Methyl-3,4-diphenylisoxazole

Isoxazole, 5-Methyl-3,4-diphenyl- (Parecoxib sodiuM intermediate)

lsoxazole,5-Methyl-3,4-diphenyl-(Parecoxib sodiuM inteMediate)

5-Methyl-3,4-diphenyl

Parecoxib Impurity 19 (Desulfonamide)

37928-17-9

37928-19-7

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