5-Methyl-3,4-diphenylisoxazole
- Product Name
- 5-Methyl-3,4-diphenylisoxazole
- CAS No.
- 37928-17-9
- Chemical Name
- 5-Methyl-3,4-diphenylisoxazole
- Synonyms
- 5-Methyl-3;CAS:37928-17-9;Parecoxib Sodium-4;5-Methyl-3,4-diphenyl;Parecoxib Related Compound;5-Methyl-3,4-diphenylisoxazole;3,4-Diphenyl-5-methylisoxazole;Parecoxib SodiuM interMediate A;Parecoxib SodiuM iMpurity PR-SM;Isoxazole, 5-Methyl-3,4-diphenyl-
- CBNumber
- CB52604537
- Molecular Formula
- C16H13NO
- Formula Weight
- 235.28
- MOL File
- 37928-17-9.mol
5-Methyl-3,4-diphenylisoxazole Property
- Melting point:
- 96.0 to 100.0 °C
- Boiling point:
- 340.1±21.0 °C(Predicted)
- Density
- 1.108±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- -2.53±0.50(Predicted)
- color
- White to Off-White
- InChIKey
- ZXIRUKJWLADSJS-UHFFFAOYSA-N
Safety
- HS Code
- 2934.99.4400
N-Bromosuccinimide Price
- Product number
- M2830
- Product name
- 5-Methyl-3,4-diphenylisoxazole
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $36
- Updated
- 2024/03/01
- Product number
- M2830
- Product name
- 5-Methyl-3,4-diphenylisoxazole
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $91
- Updated
- 2024/03/01
- Product number
- M312540
- Product name
- 5-Methyl-3,4-diphenylisoxazole
- Packaging
- 500mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- CHM0390904
- Product name
- 5-METHYL-3,4-DIPHENYLISOXAZOLE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $497.88
- Updated
- 2021/12/16
- Product number
- Y0376
- Product name
- 5-Methyl-3,4-diphenylisoxazole
- Packaging
- 25g
- Price
- $178
- Updated
- 2021/12/16
5-Methyl-3,4-diphenylisoxazole Chemical Properties,Usage,Production
Uses
5-Methyl-3,4-diphenylisoxazole is synthesis The key intermediate of Parecoxib Sodium (Parecoxib Sodium).Parecoxib Sodium is by the Pfizer of the U.S. The cox 2 inhibitor of company's research and development, listed in European Union in 2002, trade name Dynastat, is used for The short term therapy of postoperative pain.
Uses
5-Methyl-3,4-diphenylisoxazole is a reagent for the preparation of valdecoxib and valdecoxib analogues.
Synthesis
In four mouthfuls of round-bottomed flasks of a 1L add compound 2 (40g), methanol (400mL), 7.7% Aqueous sodium carbonate (400mL), is heated to 70 DEG C, after stirring reaction 2h, and TLC plate monitoring raw material Fundamental reaction is complete, and solution is divided into solid-liquid biphase, is extracted with ethyl acetate, collected organic layer, with anhydrous Sodium sulfate is dried, and vacuum obtains white solid, HPLC purity: 94.9% after being spin-dried for.White solid uses 40ml ethyl acetate and the mixed solvent recrystallization of 120ml normal hexane (1:3) again, Obtaining target compound is white solid 34.2g, yield 92%, HPLC purity: 99.7%.m.p.97-98??￡? MS(m/z):236(M+H)+￡?1H NMR(400MHz,CDCl3) |?:2.43(s,3H,-CH3), 7.19-7.43 (m, 10H ,-CH=).
5-Methyl-3,4-diphenylisoxazole Preparation Products And Raw materials
Raw materials
Preparation Products
5-Methyl-3,4-diphenylisoxazole Suppliers
- Tel
- 03-36680489
- Fax
- 03-3668-0520
- Sales-JP@TCIchemicals.com
- Country
- Japan
- ProdList
- 28398
- Advantage
- 80
View Lastest Price from 5-Methyl-3,4-diphenylisoxazole manufacturers
- Product
- 5-Methyl-3,4-diphenylisoxazole 37928-17-9
- Price
- US $100.00-60.00/Grams
- Min. Order
- 100Grams
- Purity
- 99.99%
- Supply Ability
- 100Tons
- Release date
- 2023-03-06
- Product
- 5-Methyl-3,4-diphenylisoxazole 37928-17-9
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 20tons
- Release date
- 2023-10-09
- Product
- 5-Methyl-3,4-diphenylisoxazole 37928-17-9
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 500KG
- Release date
- 2023-07-06