ChemicalBook > CAS DataBase List > PARECOXIB SODIUM

PARECOXIB SODIUM

Product Name: PARECOXIB SODIUM
CAS No.: 198470-85-8
Chemical Name: PARECOXIB SODIUM
Synonyms: Dynastat;Rayzon;SC 69124A;Parecoxib CRS;parexib sodium;Parecoxib-011-Na;Parecoxib sodium;Parecoxib sodiuM sal;Parecoxib sodiuM salt;Parecoxib Impurity 64
CBNumber: CB21003464
Molecular Formula: C19H19N2NaO4S
Formula Weight: 394.42
MOL File: 198470-85-8.mol

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PARECOXIB SODIUM Property

Melting point:: 273-275°C
storage temp.: Inert atmosphere,2-8°C
solubility: DMF: 10mg/mL; DMSO: 15mg/mL; Ethanol: 3mg/mL; PBS (pH 7.2): 5mg/mL
form: Powder
color: White to off-white
Water Solubility: H2O: 2mg/mL, clear
InChI: InChI=1S/C19H18N2O4S.Na.H/c1-3-17(22)21-26(23,24)16-11-9-14(10-12-16)18-13(2)25-20-19(18)15-7-5-4-6-8-15;;/h4-12H,3H2,1-2H3,(H,21,22);;
InChIKey: OGSQVUBPCQXSGW-UHFFFAOYSA-N
SMILES: CC1ON=C(C2C=CC=CC=2)C=1C1C=CC(S(=O)(=O)NC(=O)CC)=CC=1.[NaH]

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML2217
Product name: Parecoxib sodium
Purity: ≥98% (HPLC)
Packaging: 25 mg
Price: $125.4
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML2217
Product name: Parecoxib sodium
Purity: ≥98% (HPLC)
Packaging: 100 mg
Price: $397
Updated: 2025/07/31

TCI Chemical

Product number: P3100
Product name: Parecoxib Sodium
Packaging: 1G
Price: $156
Updated: 2025/07/31

Cayman Chemical

Product number: 29017
Product name: Parecoxib (sodium salt)
Packaging: 10mg
Price: $62
Updated: 2024/03/01

Cayman Chemical

Product number: 29017
Product name: Parecoxib (sodium salt)
Packaging: 25mg
Price: $113
Updated: 2024/03/01

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PARECOXIB SODIUM Chemical Properties,Usage,Production

Description

Parecoxib is a prodrug form of the COX-2 inhibitor valdecoxib . It is converted to valdecoxib by human liver microsomes in vitro and in vivo in rats, dogs, and cynomolgous monkeys. Parecoxib is also a cannabinoid (CB) receptor 1 agonist with an EC₅₀ value of 2.4 μM in HEK293 cells. It reduces hyperalgesia in a rat model of carrageenan-induced foot pad edema (ED₅₀ = 5 mg/kg) and decreases inflammation in a rat model of M. butyricum-induced arthritis (ED₅₀ = 0.08 mg/kg).

Chemical Properties

White Solid

Uses

Anti-inflammatory, analgesic.

Indications

For the short-term treatment of acute pain and post-operative pain i.e., oral surgery, abdominal hysterectomy, myomectomy, total knee replacement, total hip arthroplasty, laparoscopic cholecystectomy, inguinal hernia repair and other general surgery like diagnostic laparoscopy, gastrectomy, hernioplasty, appendectomy, hemithyroidectomy and splenectomy. Parecoxib Sodium may be used pre-operatively to prevent or reduce post-operative pain and it can reduce opioid requirements when they are used concomitantly.

Biological Functions

A water-soluble, injectable sodium salt form of parecoxib, an amide prodrug of the cyclooxygenase II (COX-2) selective, non-steroidal anti-inflammatory drug (NSAID) valdecoxib, with anti-inflammatory, analgesic, and antipyretic activities. Valdecoxib selectively binds to and inhibits COX-2. This prevents the conversion of arachidonic acid into prostaglandins, which are involved in the regulation of pain, inflammation, and fever. This NSAID does not inhibit COX-1 at therapeutic concentrations and, therefore, does not interfere with blood coagulation.

Pharmacokinetics

Parecoxib (Dynastat) is a prodrug of valdecoxib. Valdecoxib is an NSAID that exhibits antiinflammatory, analgesic and antipyretic properties in animal models. The mechanism of action is believed to be due to inhibition of prostaglandin synthesis primarily through inhibition of COX-2. At therapeutic plasma concentrations in humans valdecoxib does not inhibit cyclooxygenase-1 (COX-1).

References

[1] JOHN J. TALLEY. N-[[(5-Methyl-3-phenylisoxazol-4-yl)- phenyl]sulfonyl]propanamide, Sodium Salt, Parecoxib Sodium: A Potent and Selective Inhibitor of COX-2 for Parenteral Administration[J]. Journal of Medicinal Chemistry, 2000, 43 9: 1661-1663. DOI: 10.1021/jm000069h
[2] HELMUT SCHR?DER Axel B Volker H?llt. Parecoxib and its metabolite valdecoxib directly interact with cannabinoid binding sites in CB1-expressing HEK 293 cells and rat brain tissue[J]. Neurochemistry international, 2011, 58 1: Pages 9-13. DOI: 10.1016/j.neuint.2010.10.018

PARECOXIB SODIUM Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from PARECOXIB SODIUM manufacturers

Sinoway Industrial co., ltd.

Product: Parecoxib Sodium 198470-85-8
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99% up,PMDA,DMF
Supply Ability: 20TONS
Release date: 2025-07-09

Hebei Chuanghai Biotechnology Co., Ltd

Product: PARECOXIB SODIUM 198470-85-8
Price: US $10.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100 mt
Release date: 2024-11-20

Moxin Chemicals

Product: Parecoxib Sodium Salt 198470-85-8
Price: US $0.00-0.00/mg
Min. Order: 10mg
Purity: 98
Supply Ability: 10000000
Release date: 2025-02-24

198470-85-8, PARECOXIB SODIUMRelated Search:

N-((4-(5-Methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)isobutyraMide 5-Methyl-3-phenyl-4-(phenylMethyl)isoxazole Valdecoxib 3'-Sulfonyl Chloride IMpurity 5-METHYL-3,4-DIPHENYL-4,5-DIHYDROISOXAZOL-5-OL 3-(5-Methyl-3-phenylisoxazol-4-yl)benzenesulfonaMide 4-(4-chlorophenyl)-5-methyl-3-phenylisoxazole 2-Phenylacetophenone Valdecoxib IMpurity B Pantoprazole Sodium Paliperidone Z-Oxime 4-(3-methyl-4-phenylisoxazol-5-yl)benzenesulfonamide ethyl 4-(5-methyl-3-phenylisoxazol-4-yl)benzenesulfonate 5-Methyl-3,4-diphenylisoxazole DeoxyBenzoinOxime Valdecoxib 3'-SulfonaMide IMpurity Parecoxib Impurity H Parecoxib Valdecoxib

Parecoxib sodium （Intermediate in China ONLY）

N-[4-(5-METHYL-3-PHENYLISOXAZOL-4-YL)PHENYLSULFONYL]PROPIONAMIDE, SODIUM SALT

Parecoxib sodiuM salt

Dynastat

N-[[4-(5-Methyl-3-phenyl-4-isoxazolyl)phenyl]sulfonyl]propanaMide SodiuM Salt

Rayzon

SC 69124A

PropanaMide,N-[[4-(5-Methyl-3-phenyl-4-isoxazolyl)phenyl]sulfonyl]-, sodiuM salt (1:1)

Parecoxib sodiuM cloth

Parecoxib sodium N-[4-(5-Methyl-3-phenylisoxazol-4-yl)phenylsulfonyl]propionamide sodium salt

Parecoxib Sodium Impurity

Parecoxib sodiuM sal

sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide

Parecoxib-011-Na

Parecoxib Impurity 64

PARECOXIB SODIUM USP/EP/BP

sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonysodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl) (propionyl)amidel) (propionyl)amide

N-[[4-(5-Methyl-3-phenyl-4-isoxazolyl)phenyl]sulfonyl]propanamide Sodium Salt（Parecoxib Sodium）

N-[4-(5-methyl-3-phenyl-1,2-oxazol-4-yl)benzenesulfonyl]propanamide sodium hydride

Parecoxib sodium

Parecoxib CRS

parexib sodium

Parecoxib Impurity 11 Sodium Salt

Parecoxib Impurity 22 Sodium Salt

Parecoxib sodium salt - Bio-X ?

Ketoprofen Lysine Salt CAS57469-78-0

198470-85-8

198470-85-5

98470-85-8

10.98470-85-8

C19H17N2NaO4S

C19H17N2O4SNa

C19H18N2O4SNa

Aromatics

Heterocycles

Intermediates & Fine Chemicals

Pharmaceuticals

198470-85-8