ChemicalBook > CAS DataBase List > PARECOXIB SODIUM

PARECOXIB SODIUM

Product Name
PARECOXIB SODIUM
CAS No.
198470-85-8
Chemical Name
PARECOXIB SODIUM
Synonyms
Dynastat;Rayzon;SC 69124A;Parecoxib CRS;parexib sodium;Parecoxib-011-Na;Parecoxib sodium;Parecoxib sodiuM sal;Parecoxib sodiuM salt;Parecoxib Impurity 64
CBNumber
CB21003464
Molecular Formula
C19H19N2NaO4S
Formula Weight
394.42
MOL File
198470-85-8.mol
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PARECOXIB SODIUM Property

Melting point:
273-275°C
storage temp. 
Inert atmosphere,2-8°C
solubility 
DMF: 10mg/mL; DMSO: 15mg/mL; Ethanol: 3mg/mL; PBS (pH 7.2): 5mg/mL
form 
Powder
InChI
InChI=1S/C19H18N2O4S.Na.H/c1-3-17(22)21-26(23,24)16-11-9-14(10-12-16)18-13(2)25-20-19(18)15-7-5-4-6-8-15;;/h4-12H,3H2,1-2H3,(H,21,22);;
InChIKey
OGSQVUBPCQXSGW-UHFFFAOYSA-N
SMILES
CC1ON=C(C2C=CC=CC=2)C=1C1C=CC(S(=O)(=O)NC(=O)CC)=CC=1.[NaH]
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H225Highly Flammable liquid and vapour

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
29017
Product name
Parecoxib (sodium salt)
Packaging
10mg
Price
$62
Updated
2024/03/01
Cayman Chemical
Product number
29017
Product name
Parecoxib (sodium salt)
Packaging
25mg
Price
$113
Updated
2024/03/01
Cayman Chemical
Product number
29017
Product name
Parecoxib (sodium salt)
Packaging
50mg
Price
$211
Updated
2024/03/01
Cayman Chemical
Product number
29017
Product name
Parecoxib (sodium salt)
Packaging
100mg
Price
$357
Updated
2024/03/01
TRC
Product number
P193275
Product name
ParecoxibSodium
Packaging
100mg
Price
$995
Updated
2021/12/16
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PARECOXIB SODIUM Chemical Properties,Usage,Production

Description

Parecoxib is a prodrug form of the COX-2 inhibitor valdecoxib . It is converted to valdecoxib by human liver microsomes in vitro and in vivo in rats, dogs, and cynomolgous monkeys. Parecoxib is also a cannabinoid (CB) receptor 1 agonist with an EC50 value of 2.4 μM in HEK293 cells. It reduces hyperalgesia in a rat model of carrageenan-induced foot pad edema (ED50 = 5 mg/kg) and decreases inflammation in a rat model of M. butyricum-induced arthritis (ED50 = 0.08 mg/kg).

Chemical Properties

White Solid

Uses

Anti-inflammatory, analgesic.

Indications

For the short-term treatment of acute pain and post-operative pain i.e., oral surgery, abdominal hysterectomy, myomectomy, total knee replacement, total hip arthroplasty, laparoscopic cholecystectomy, inguinal hernia repair and other general surgery like diagnostic laparoscopy, gastrectomy, hernioplasty, appendectomy, hemithyroidectomy and splenectomy. Parecoxib Sodium may be used pre-operatively to prevent or reduce post-operative pain and it can reduce opioid requirements when they are used concomitantly.

Biological Functions

A water-soluble, injectable sodium salt form of parecoxib, an amide prodrug of the cyclooxygenase II (COX-2) selective, non-steroidal anti-inflammatory drug (NSAID) valdecoxib, with anti-inflammatory, analgesic, and antipyretic activities. Valdecoxib selectively binds to and inhibits COX-2. This prevents the conversion of arachidonic acid into prostaglandins, which are involved in the regulation of pain, inflammation, and fever. This NSAID does not inhibit COX-1 at therapeutic concentrations and, therefore, does not interfere with blood coagulation.

Pharmacokinetics

Parecoxib (Dynastat) is a prodrug of valdecoxib. Valdecoxib is an NSAID that exhibits antiinflammatory, analgesic and antipyretic properties in animal models. The mechanism of action is believed to be due to inhibition of prostaglandin synthesis primarily through inhibition of COX-2. At therapeutic plasma concentrations in humans valdecoxib does not inhibit cyclooxygenase-1 (COX-1).

PARECOXIB SODIUM Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from PARECOXIB SODIUM manufacturers

Hebei Dangtong Import and export Co LTD
Product
198470-85-8 198470-85-8
Price
US $100.00-60.00/kg
Min. Order
100kg
Purity
99.99%
Supply Ability
100Tons
Release date
2023-03-17
PUSHAN INDUSTRIAL (SHAANXI) CO.,LTD
Product
Parecoxib Sodium 198470-85-8
Price
US $0.00/kg
Min. Order
1kg
Purity
98% HPLC
Supply Ability
1000 kgs
Release date
2024-05-15
Ouhuang Engineering Materials (Hubei) Co., Ltd
Product
Parecoxib sodiuM 198470-85-8
Price
US $15.00/kg
Min. Order
1kg
Purity
99.912%
Supply Ability
10ton
Release date
2024-04-25

198470-85-8, PARECOXIB SODIUMRelated Search:

N-((4-(5-Methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)isobutyraMide 5-Methyl-3-phenyl-4-(phenylMethyl)isoxazole Valdecoxib 3'-Sulfonyl Chloride IMpurity 5-METHYL-3,4-DIPHENYL-4,5-DIHYDROISOXAZOL-5-OL 3-(5-Methyl-3-phenylisoxazol-4-yl)benzenesulfonaMide 4-(4-chlorophenyl)-5-methyl-3-phenylisoxazole 2-Phenylacetophenone Valdecoxib IMpurity B Pantoprazole Sodium Paliperidone Z-Oxime 4-(3-methyl-4-phenylisoxazol-5-yl)benzenesulfonamide ethyl 4-(5-methyl-3-phenylisoxazol-4-yl)benzenesulfonate 5-Methyl-3,4-diphenylisoxazole DeoxyBenzoinOxime Valdecoxib 3'-SulfonaMide IMpurity Parecoxib Impurity H Parecoxib Valdecoxib

  • Parecoxib sodium （Intermediate in China ONLY）
  • N-[4-(5-METHYL-3-PHENYLISOXAZOL-4-YL)PHENYLSULFONYL]PROPIONAMIDE, SODIUM SALT
  • Parecoxib sodiuM salt
  • Dynastat
  • N-[[4-(5-Methyl-3-phenyl-4-isoxazolyl)phenyl]sulfonyl]propanaMide SodiuM Salt
  • Rayzon
  • SC 69124A
  • PropanaMide,N-[[4-(5-Methyl-3-phenyl-4-isoxazolyl)phenyl]sulfonyl]-, sodiuM salt (1:1)
  • Parecoxib sodiuM cloth
  • Parecoxib sodium N-[4-(5-Methyl-3-phenylisoxazol-4-yl)phenylsulfonyl]propionamide sodium salt
  • Parecoxib Sodium Impurity
  • Parecoxib sodiuM sal
  • sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide
  • Parecoxib-011-Na
  • Parecoxib Impurity 64
  • PARECOXIB SODIUM USP/EP/BP
  • sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonysodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl) (propionyl)amidel) (propionyl)amide
  • N-[[4-(5-Methyl-3-phenyl-4-isoxazolyl)phenyl]sulfonyl]propanamide Sodium Salt（Parecoxib Sodium）
  • N-[4-(5-methyl-3-phenyl-1,2-oxazol-4-yl)benzenesulfonyl]propanamide sodium hydride
  • Parecoxib sodium
  • Parecoxib Impurity 22 Sodium Salt
  • Parecoxib CRS
  • parexib sodium
  • Parecoxib Impurity 11 Sodium Salt
  • 198470-85-8
  • 198470-85-5
  • 98470-85-8
  • 10.98470-85-8
  • C19H17N2NaO4S
  • C19H17N2O4SNa
  • C19H18N2O4SNa
  • Aromatics
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • 198470-85-8