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Pantoprazole Sodium

Product Name
Pantoprazole Sodium
CAS No.
138786-67-1
Chemical Name
Pantoprazole Sodium
Synonyms
PANTOZOL;Pantoloc;Protonix;Pantoprazol Sodium;Zurcal;Nolpaza;PANTECTA;EUPANTOL;Controloc;midazolesodium
CBNumber
CB0415897
Molecular Formula
C16H14F2N3NaO4S
Formula Weight
405.35
MOL File
138786-67-1.mol
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Pantoprazole Sodium Property

Melting point:
199-202°C
storage temp. 
Inert atmosphere,Store in freezer, under -20°C
solubility 
DMSO (Slightly), Methanol (Slightly, Sonicated), Water (Slightly)
form 
Solid
color 
White to Pale Beige
Stability:
Hygroscopic
InChIKey
YNWDKZIIWCEDEE-UHFFFAOYSA-N
CAS DataBase Reference
138786-67-1(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn
Risk Statements 
20/21/22-37/38-41-48
Safety Statements 
22-26-36/37/39-45
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
Y0001001
Product name
Pantoprazole for system suitability
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
y0001001
Price
$220
Updated
2024/03/01
Usbiological
Product number
P3040
Product name
Pantoprazole, Sodium Salt
Packaging
100mg
Price
$403
Updated
2021/12/16
TRC
Product number
P183000
Product name
PantoprazoleSodiumSalt
Packaging
1g
Price
$970
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
12899
Product name
Pantoprazolesodiumsalt
Packaging
250mg
Price
$590
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
12899
Product name
Pantoprazolesodiumsalt
Packaging
50mg
Price
$190
Updated
2021/12/16
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Pantoprazole Sodium Chemical Properties,Usage,Production

Chemical Properties

White to Off-White Solid

Originator

Controloc,Byk Gulden ,Germany

Uses

An antiulcerative. Gastric pump inhibitor.

Uses

Gastrointestinal

Definition

ChEBI: Pantoprazole sodium is an organic sodium salt. It has a role as an EC 3.6.3.10 (H(+)/K(+)-exchanging ATPase) inhibitor and an anti-ulcer drug. It contains a pantoprazole(1-).

Manufacturing Process

2-Chloromethyl-4,5-dimethoxy-3-methylpyridinium chloride (about 1.5 g) are added to a solution of 5-difluoromethoxy-1H-benzimidazole-2-thiol in 10 ml of ethanol and 10 ml of 1 N sodium hydroxide solution. The yellow reaction mixture is stirred at 20°C for 1 hour, a further 10 ml of water are added, whereupon a colorless solid precipitates out, the mixture is stirred for a further 5 hours and filtered and the residue is rinsed with 1 N sodium hydroxide solution and water and dried to constant weight. The 5difluoromethoxy-2-[(4,5-dimethoxy-2-pyridyl)methylthio]-1H-benzimidazole is obtained as an oil.
5-Difluoromethoxy-2-[(4,5-dimethoxy-2-pyridyl)methylthio]-1H-benzimidazole (about 1 g) are dissolved in 10 ml of dioxane and 2 ml of 1 N sodium hydroxide solution. An equimolar amount of a titrated aqueous sodium hypochlorite solution, to which 1 mole per liter of sodium hydroxide solution has been added, is first added dropwise, while cooling with ice. After one hour a further equivalent and after 3 hours half the equimolar amount of sodium hypochlorite are added, to achieve complete reaction. After a reaction time of 4 hours, 5 ml of 5% strength sodium thiosulfate solution and another 25 ml of dioxane are added and the upper dioxane phase is separated off, washed once with 5 ml of sodium thiosulfate solution and concentrated on a rotary evaporator. The oily residue is dissolved in 20 ml of water and 10 ml of ethyl acetate and the solution is brought to pH 7 with about 100 ml of a buffer solution of pH 6.8. The solid which has precipitated out is filtered off with suction over a suction filter, washed with water, extracted by stirring at 0C with acetone and dried. 5-Difluoromethoxy-2-[(4,5-dimethoxy-2pyridyl)methanesulfinyl]-1H-benzimidazole is prepared; yield about 85%.

brand name

Protonix (Wyeth).

Therapeutic Function

Antiulcer

General Description

Pantoprazole sodium, racemicsodium5-(difluoromethoxy)-2-[[3,4-dimethoxy-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole sesquihydrate is a white tooff-white crystalline powder that is freely soluble in water,very slightly soluble in phosphate buffer at pH 7.4, and practicallyinsoluble in n-hexane. The benzimidazole of this drughas a weakly basic nitrogen (pyridine N, pKa 3.83) and an benzimidazoleproton (pKa 0.11), facilitating formulation as asodium salt. The stability of the compound in aqueous solutionis pH dependent; the rate of degradation increases with decreasingpH. At ambient temperature, the degradation half-lifeis approximately 2.8 hours at pH 5.0 and approximately 220hours at pH 7.8.
The absorption of pantoprazole is rapid (Cmax of2.5μg/mL, Tmax 2.5 hours) after single or multiple oral40-mg doses. Pantoprazole is well absorbed (77% bioavailability).Administration with food may delay its absorptionbut does not alter pantoprazole bioavailability. Pantoprazoleis distributed mainly in extracellular fluid. The serum proteinbinding of pantoprazole is about 98%, primarily to albumin.Pantoprazole is extensively metabolized in the liver throughthe CYP system, including O-demethylation (CYP2C19),with subsequent sulfation. Other metabolic pathways includesulfur oxidation by CYP3A4. There is no evidencethat any of the pantoprazole metabolites have significantpharmacological activity. Approximately 71% of a dose of pantoprazole is excreted in the urine, with 18% excretedin the feces through biliary excretion.

Pantoprazole Sodium Preparation Products And Raw materials

Raw materials

Preparation Products

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Pantoprazole Sodium Suppliers

Henan Huawen Chemical Co., Ltd
Tel
0370-0370-2059268 17550075363
Fax
QQ:2712427897
Email
1124977392@qq.com
Country
China
ProdList
2283
Advantage
58
Henan Dobe Chemical Co. , Ltd.
Tel
0370-6999054 17334723986
Email
2794293116@qq.com
Country
China
ProdList
1346
Advantage
58
Hebei mo Jin biotechnology co., ltd
Tel
13288715578
Email
angelia@hbmojin.com
Country
China
ProdList
1689
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
INTATRADE GmbH
Tel
+49 3493/605464
Fax
+49 3493/605470
Email
sales@intatrade.de
Country
Germany
ProdList
3572
Advantage
66
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
Advantage
69
Chembest Research Laboratories Limited
Tel
+86-21-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6005
Advantage
61
TAIYUAN RHF CO.,LTD.
Tel
+86 351 7031519
Fax
+86 351 7031519
Email
sales@RHFChem.com
Country
China
ProdList
2338
Advantage
56
Beijing HwrkChemical Technology Co., Ltd
Tel
010-89508211 18501085097
Fax
010-89508210
Email
sales.bj@hwrkchemical.com
Country
China
ProdList
8415
Advantage
55
JinYan Chemicals(ShangHai) Co.,Ltd.
Tel
13817811078
Fax
86-021-50426522,50426273
Email
sales@jingyan-chemical.com
Country
China
ProdList
9976
Advantage
60
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View Lastest Price from Pantoprazole Sodium manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Pantoprazole Sodium 138786-67-1
Price
US $1.00/KG
Min. Order
1KG
Purity
99.0%~101.0%,EP9.0
Supply Ability
1000kg/month
Release date
2021-06-21
Hebei Weibang Biotechnology Co., Ltd
Product
Pantoprazole Sodium 138786-67-1
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2022-09-30
Baoji Guokang Bio-Technology Co., Ltd.
Product
Pantoprazole Sodium 138786-67-1
Price
US $460.00/Kg/Bag
Min. Order
1KG
Purity
99%
Supply Ability
1T
Release date
2021-06-04

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