Pantoprazole Sodium
- Product Name
- Pantoprazole Sodium
- CAS No.
- 138786-67-1
- Chemical Name
- Pantoprazole Sodium
- Synonyms
- PANTOZOL;Pantoloc;Protonix;Pantoprazol Sodium;Zurcal;Nolpaza;PANTECTA;EUPANTOL;Controloc;midazolesodium
- CBNumber
- CB0415897
- Molecular Formula
- C16H14F2N3NaO4S
- Formula Weight
- 405.35
- MOL File
- 138786-67-1.mol
Pantoprazole Sodium Property
- Melting point:
- 199-202°C
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- solubility
- DMSO (Slightly), Methanol (Slightly, Sonicated), Water (Slightly)
- form
- Solid
- color
- White to Pale Beige
- Stability:
- Hygroscopic
- InChI
- InChI=1S/C16H14F2N3O4S.Na/c1-23-13-5-6-19-12(14(13)24-2)8-26(22)16-20-10-4-3-9(25-15(17)18)7-11(10)21-16;/h3-7,15H,8H2,1-2H3;/q-1;+1
- InChIKey
- YNWDKZIIWCEDEE-UHFFFAOYSA-N
- SMILES
- C12C=C(C=CC=1N(C(S(=O)CC1N=CC=C(OC)C=1OC)=N2)[Na])OC(F)F
- CAS DataBase Reference
- 138786-67-1(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn
- Risk Statements
- 20/21/22-37/38-41-48
- Safety Statements
- 22-26-36/37/39-45
N-Bromosuccinimide Price
- Product number
- Y0001001
- Product name
- Pantoprazole for system suitability
- Purity
- European Pharmacopoeia (EP) Reference Standard
- Packaging
- y0001001
- Price
- $220
- Updated
- 2024/03/01
- Product number
- P3040
- Product name
- Pantoprazole, Sodium Salt
- Packaging
- 100mg
- Price
- $403
- Updated
- 2021/12/16
- Product number
- P183000
- Product name
- PantoprazoleSodiumSalt
- Packaging
- 1g
- Price
- $970
- Updated
- 2021/12/16
- Product number
- 12899
- Product name
- Pantoprazolesodiumsalt
- Packaging
- 250mg
- Price
- $590
- Updated
- 2021/12/16
- Product number
- 12899
- Product name
- Pantoprazolesodiumsalt
- Packaging
- 50mg
- Price
- $190
- Updated
- 2021/12/16
Pantoprazole Sodium Chemical Properties,Usage,Production
Chemical Properties
White to Off-White Solid
Originator
Controloc,Byk Gulden ,Germany
Uses
Gastrointestinal
Uses
An antiulcerative. Gastric pump inhibitor.
Definition
ChEBI: Pantoprazole sodium is an organic sodium salt. It has a role as an EC 3.6.3.10 (H(+)/K(+)-exchanging ATPase) inhibitor and an anti-ulcer drug. It contains a pantoprazole(1-).
Manufacturing Process
2-Chloromethyl-4,5-dimethoxy-3-methylpyridinium chloride (about 1.5 g) are added to a solution of 5-difluoromethoxy-1H-benzimidazole-2-thiol in 10 ml of ethanol and 10 ml of 1 N sodium hydroxide solution. The yellow reaction mixture is stirred at 20°C for 1 hour, a further 10 ml of water are added,
whereupon a colorless solid precipitates out, the mixture is stirred for a further 5 hours and filtered and the residue is rinsed with 1 N sodium hydroxide solution and water and dried to constant weight. The 5difluoromethoxy-2-[(4,5-dimethoxy-2-pyridyl)methylthio]-1H-benzimidazole is obtained as an oil.
5-Difluoromethoxy-2-[(4,5-dimethoxy-2-pyridyl)methylthio]-1H-benzimidazole (about 1 g) are dissolved in 10 ml of dioxane and 2 ml of 1 N sodium hydroxide solution. An equimolar amount of a titrated aqueous sodium hypochlorite solution, to which 1 mole per liter of sodium hydroxide solution has been added, is first added dropwise, while cooling with ice. After one hour a further equivalent and after 3 hours half the equimolar amount of sodium hypochlorite are added, to achieve complete reaction. After a reaction time of 4 hours, 5 ml of 5% strength sodium thiosulfate solution and another 25 ml of dioxane are added and the upper dioxane phase is separated off, washed once with 5 ml of sodium thiosulfate solution and concentrated on a rotary evaporator. The oily residue is dissolved in 20 ml of water and 10 ml of ethyl acetate and the solution is brought to pH 7 with about 100 ml of a buffer solution of pH 6.8. The solid which has precipitated out is filtered off with suction over a suction filter, washed with water, extracted by stirring at 0C with acetone and dried. 5-Difluoromethoxy-2-[(4,5-dimethoxy-2pyridyl)methanesulfinyl]-1H-benzimidazole is prepared; yield about 85%.
brand name
Protonix (Wyeth).
Therapeutic Function
Antiulcer
General Description
Pantoprazole sodium, racemicsodium5-(difluoromethoxy)-2-[[3,4-dimethoxy-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole sesquihydrate is a white tooff-white crystalline powder that is freely soluble in water,very slightly soluble in phosphate buffer at pH 7.4, and practicallyinsoluble in n-hexane. The benzimidazole of this drughas a weakly basic nitrogen (pyridine N, pKa 3.83) and an benzimidazoleproton (pKa 0.11), facilitating formulation as asodium salt. The stability of the compound in aqueous solutionis pH dependent; the rate of degradation increases with decreasingpH. At ambient temperature, the degradation half-lifeis approximately 2.8 hours at pH 5.0 and approximately 220hours at pH 7.8.
The absorption of pantoprazole is rapid (Cmax of2.5μg/mL, Tmax 2.5 hours) after single or multiple oral40-mg doses. Pantoprazole is well absorbed (77% bioavailability).Administration with food may delay its absorptionbut does not alter pantoprazole bioavailability. Pantoprazoleis distributed mainly in extracellular fluid. The serum proteinbinding of pantoprazole is about 98%, primarily to albumin.Pantoprazole is extensively metabolized in the liver throughthe CYP system, including O-demethylation (CYP2C19),with subsequent sulfation. Other metabolic pathways includesulfur oxidation by CYP3A4. There is no evidencethat any of the pantoprazole metabolites have significantpharmacological activity. Approximately 71% of a dose of pantoprazole is excreted in the urine, with 18% excretedin the feces through biliary excretion.
Biological Activity
Gastric proton pump inhibitor. It is used for short-term treatment of erosion and ulceration of the esophagus caused by gastroesophageal reflux disease.
Pantoprazole Sodium Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Pantoprazole Sodium manufacturers
- Product
- Pantoprazole Sodium 138786-67-1
- Price
- US $150.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 500kg
- Release date
- 2024-12-25
- Product
- Pantoprazole Sodium 138786-67-1
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99.0%~101.0%,EP9.0
- Supply Ability
- 1000kg/month
- Release date
- 2021-06-21
- Product
- Pantoprazole Sodium 138786-67-1
- Price
- US $460.00/Kg/Bag
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 1T
- Release date
- 2021-06-04