ChemicalBook > CAS DataBase List > Pantoprazole Sodium

Pantoprazole Sodium

Product Name
Pantoprazole Sodium
CAS No.
138786-67-1
Chemical Name
Pantoprazole Sodium
Synonyms
PANTOZOL;Pantoloc;Protonix;Pantoprazol Sodium;Zurcal;Nolpaza;PANTECTA;EUPANTOL;Controloc;midazolesodium
CBNumber
CB0415897
Molecular Formula
C16H14F2N3NaO4S
Formula Weight
405.35
MOL File
138786-67-1.mol
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Pantoprazole Sodium Property

Melting point:
199-202°C
storage temp. 
Inert atmosphere,Store in freezer, under -20°C
solubility 
DMSO (Slightly), Methanol (Slightly, Sonicated), Water (Slightly)
form 
Solid
color 
White to Pale Beige
Stability:
Hygroscopic
InChI
InChI=1S/C16H14F2N3O4S.Na/c1-23-13-5-6-19-12(14(13)24-2)8-26(22)16-20-10-4-3-9(25-15(17)18)7-11(10)21-16;/h3-7,15H,8H2,1-2H3;/q-1;+1
InChIKey
YNWDKZIIWCEDEE-UHFFFAOYSA-N
SMILES
C12C=C(C=CC=1N(C(S(=O)CC1N=CC=C(OC)C=1OC)=N2)[Na])OC(F)F
CAS DataBase Reference
138786-67-1(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn
Risk Statements 
20/21/22-37/38-41-48
Safety Statements 
22-26-36/37/39-45
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
Y0001001
Product name
Pantoprazole for system suitability
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
y0001001
Price
$220
Updated
2024/03/01
Usbiological
Product number
P3040
Product name
Pantoprazole, Sodium Salt
Packaging
100mg
Price
$403
Updated
2021/12/16
TRC
Product number
P183000
Product name
PantoprazoleSodiumSalt
Packaging
1g
Price
$970
Updated
2021/12/16
AK Scientific
Product number
J10399
Product name
Pantoprazole Sodium
Packaging
5mg
Price
$19.8
Updated
2021/12/16
Axon Medchem
Product number
Axon3161
Product name
Pantoprazolesodium-Protonix
Purity
99%
Packaging
50mg
Price
$55
Updated
2021/12/16
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Pantoprazole Sodium Chemical Properties,Usage,Production

Chemical Properties

White to Off-White Solid

Originator

Controloc,Byk Gulden ,Germany

Uses

An antiulcerative. Gastric pump inhibitor.

Uses

Gastrointestinal

Definition

ChEBI: Pantoprazole sodium is an organic sodium salt. It has a role as an EC 3.6.3.10 (H(+)/K(+)-exchanging ATPase) inhibitor and an anti-ulcer drug. It contains a pantoprazole(1-).

Manufacturing Process

2-Chloromethyl-4,5-dimethoxy-3-methylpyridinium chloride (about 1.5 g) are added to a solution of 5-difluoromethoxy-1H-benzimidazole-2-thiol in 10 ml of ethanol and 10 ml of 1 N sodium hydroxide solution. The yellow reaction mixture is stirred at 20°C for 1 hour, a further 10 ml of water are added, whereupon a colorless solid precipitates out, the mixture is stirred for a further 5 hours and filtered and the residue is rinsed with 1 N sodium hydroxide solution and water and dried to constant weight. The 5difluoromethoxy-2-[(4,5-dimethoxy-2-pyridyl)methylthio]-1H-benzimidazole is obtained as an oil.
5-Difluoromethoxy-2-[(4,5-dimethoxy-2-pyridyl)methylthio]-1H-benzimidazole (about 1 g) are dissolved in 10 ml of dioxane and 2 ml of 1 N sodium hydroxide solution. An equimolar amount of a titrated aqueous sodium hypochlorite solution, to which 1 mole per liter of sodium hydroxide solution has been added, is first added dropwise, while cooling with ice. After one hour a further equivalent and after 3 hours half the equimolar amount of sodium hypochlorite are added, to achieve complete reaction. After a reaction time of 4 hours, 5 ml of 5% strength sodium thiosulfate solution and another 25 ml of dioxane are added and the upper dioxane phase is separated off, washed once with 5 ml of sodium thiosulfate solution and concentrated on a rotary evaporator. The oily residue is dissolved in 20 ml of water and 10 ml of ethyl acetate and the solution is brought to pH 7 with about 100 ml of a buffer solution of pH 6.8. The solid which has precipitated out is filtered off with suction over a suction filter, washed with water, extracted by stirring at 0C with acetone and dried. 5-Difluoromethoxy-2-[(4,5-dimethoxy-2pyridyl)methanesulfinyl]-1H-benzimidazole is prepared; yield about 85%.

brand name

Protonix (Wyeth).

Therapeutic Function

Antiulcer

General Description

Pantoprazole sodium, racemicsodium5-(difluoromethoxy)-2-[[3,4-dimethoxy-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole sesquihydrate is a white tooff-white crystalline powder that is freely soluble in water,very slightly soluble in phosphate buffer at pH 7.4, and practicallyinsoluble in n-hexane. The benzimidazole of this drughas a weakly basic nitrogen (pyridine N, pKa 3.83) and an benzimidazoleproton (pKa 0.11), facilitating formulation as asodium salt. The stability of the compound in aqueous solutionis pH dependent; the rate of degradation increases with decreasingpH. At ambient temperature, the degradation half-lifeis approximately 2.8 hours at pH 5.0 and approximately 220hours at pH 7.8.
The absorption of pantoprazole is rapid (Cmax of2.5μg/mL, Tmax 2.5 hours) after single or multiple oral40-mg doses. Pantoprazole is well absorbed (77% bioavailability).Administration with food may delay its absorptionbut does not alter pantoprazole bioavailability. Pantoprazoleis distributed mainly in extracellular fluid. The serum proteinbinding of pantoprazole is about 98%, primarily to albumin.Pantoprazole is extensively metabolized in the liver throughthe CYP system, including O-demethylation (CYP2C19),with subsequent sulfation. Other metabolic pathways includesulfur oxidation by CYP3A4. There is no evidencethat any of the pantoprazole metabolites have significantpharmacological activity. Approximately 71% of a dose of pantoprazole is excreted in the urine, with 18% excretedin the feces through biliary excretion.

Pantoprazole Sodium Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Pantoprazole Sodium manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Pantoprazole Sodium 138786-67-1
Price
US $1.00/KG
Min. Order
1KG
Purity
99.0%~101.0%,EP9.0
Supply Ability
1000kg/month
Release date
2021-06-21
Baoji Guokang Bio-Technology Co., Ltd.
Product
Pantoprazole Sodium 138786-67-1
Price
US $460.00/Kg/Bag
Min. Order
1KG
Purity
99%
Supply Ability
1T
Release date
2021-06-04
Hebei Weibang Biotechnology Co., Ltd
Product
Pantoprazole Sodium 138786-67-1
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2022-09-30

138786-67-1, Pantoprazole SodiumRelated Search:

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  • 5-(DIFLUOROMETHOXY)-2-[[(3,4-DIMETHOXY-2-PYRIDINYL)METHYL]SULFINYL]-1H-BENZIMIDAZOLE
  • 5-(difluoromethoxy)-2-(((3,4-dimethoxy-2-pyridinyl)methyl) sulfinyl)-1h-benzimidazole sodium
  • 1h-benzimidazole,5-(difluoromethoxy)-2-(((3,4-dimethoxy-2-pyridinyl)methyl)sul
  • 5-(difluoromethoxy)-2-(((3,4-dimethoxy-2-pyridinyl)methyl)sulfinyl)-1h-benzi
  • midazolesodium
  • EUPANTOL
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  • PANTOPRAZOLE, SODIUM SALT
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  • 1H-benziMidazole, 5-(difluoroMethoxy)-2-[[(3,4-diMethoxy-2-pyridinyl)Methyl]sulfinyl]-, sodiuM salt (1:1)
  • Protonix sodiuM
  • SKF96022 sodiuM
  • sodiuM (S)-6-(difluoroMethoxy)-2-((3,4-diMethoxypyridin-2-yl)Methylsulfinyl)benzo[d]iMidazol-1-ide
  • 5-(Difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole sodium salt sesquihydrate
  • Pantozol sesquihydrate
  • Protonix sesquihydrate
  • 5-(difluoroMethoxy)-2-(((3,4-diMethoxypyridin-2-yl)Methyl)sulfinyl)-1H-benzo[d]iMidazole, sodiuM salt
  • 6-(difluoromethoxy)-2-[(3,4-dimethoxy-2-pyridyl)methylsulfinyl]-1H-benzimidazole
  • PANTOPRAZOLE SODIUM POWDER
  • 5-Difluoromethoxy-2-[[(3,4-dimethoxy-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole sodium salt monohydrate
  • 4-dimethoxy-2-pyridinyl)methyl) sulfinyl)-1H-benzimidazole sodium
  • Pantoprazole (as Sodium Salt)
  • Eupantol, Pantecta, Pantozol, 5-(Difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole
  • PANTOPRAZOLE SODIUM MONOHYDRATE
  • Pantoprazole sodium(factory standard)
  • 5-(Difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridynyl)methyl]-1H-benzimidazol-1-ium sodium salt
  • Controloc
  • Pantoloc
  • Protonix
  • Sodium pantoprazole
  • Pantaprazole SodiuM sesqhydrate IP
  • 5-(DifluoroMethoxy)-2-[[(3,4-diMethoxy-2-pyridinyl)Methyl]sulfinyl]- 1H-benziMidazole SodiuM Salt
  • 6-(DifluoroMethoxy)-2-[[(3,4-diMethoxy-2-pyridinyl)Methyl]sulfinyl]-1H-benziMidazole SodiuM Salt
  • Nolpaza
  • Zurcal
  • Pantoprazole Sodium (250 mg)
  • 5-(difluoromethoxy)-2-[(3,4-dimethoxy-2-pyridinyl)methylsulfinyl]benzimidazol-1-ide
  • BY-1023 sodium
  • BY1023 (sodium)
  • 1H-Benzimidazole, 6-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl)methyl]sulfinyl]-, sodium salt (1:1)
  • Sodium 5-(difluoromethoxy)-2-(((3,4-dimethoxypyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide
  • (+/-)-PANTOPRAZOLE, SODIUM SALT: SESQUI- HYDRATE (PYRIDYL-4-METHOXY-13C, 98%)
  • Pantoprazole sodium sisquehydrate
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  • Pantoprazole Sodium BP/USP
  • 6-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl)methyl]sulfinyl]-1H-Benzimidazole sodium salt (1:1)
  • 6-(Difluoromethoxy)-2-(3,4-dimethoxy-pyridin-2-yl)methylsulfinyl-1H-benzodimidazole sodium salt
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