Neratinib Maleate

Product Name: Neratinib Maleate
CAS No.: 915942-22-2
Chemical Name: Neratinib Maleate
Synonyms: Nerlynx;Neratinib Maleate;Neratinib Maleate USP/EP/BP;(2E)-N-(4-{[3-Chloro-4-(2-pyridinylmethoxy)phenyl]amino}-3-c...;(E)-N-[4-[3-Chloro-4-[(2-pyridinyl)methoxy]anilino]-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide maleate;(E)-N-{4-[3-chloro-4-(pyridin-2-yl methoxy) anilino]-3-cyano-7-ethoxyquinolin-6-yl}-4- (dimethylamino)but-2-enamide maleate;(2E)-N-(4-{[3-Chloro-4-(2-pyridinylmethoxy)phenyl]amino}-3-cyano-7-ethoxy-6-quinolinyl)-4-(dimethylamino)-2-butenamide (2Z)-2-butenedioate (1:1);2-Butenamide, N-[4-[[3-chloro-4-(2-pyridinylmethoxy)phenyl]amino]-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-, (2E)-, (2Z)-2-butenedioate (1:1)
CBNumber: CB52723515
Molecular Formula: C34H33ClN6O7
Formula Weight: 673.12
MOL File: 915942-22-2.mol

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Neratinib Maleate Property

storage temp.: Inert atmosphere,Room Temperature

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Biosynth Carbosynth

Product number: BN160240
Product name: Neratinib Maleate
Packaging: 100mg
Price: $300
Updated: 2021/12/16

Biosynth Carbosynth

Product number: BN160240
Product name: Neratinib Maleate
Packaging: 250mg
Price: $400
Updated: 2021/12/16

Biosynth Carbosynth

Product number: BN160240
Product name: Neratinib Maleate
Packaging: 500mg
Price: $500
Updated: 2021/12/16

AK Scientific

Product number: 9842BB
Product name: Neratinibmaleate
Packaging: 500mg
Price: $725
Updated: 2021/12/16

Biosynth Carbosynth

Product number: BN160240
Product name: Neratinib Maleate
Packaging: 2g
Price: $900
Updated: 2021/12/16

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Neratinib Maleate Chemical Properties,Usage,Production

Description

Neratinib (HKI-272) is a pan-HER inhibitor, this irreversible tyrosine kinase inhibitor binds and inhibits the tyrosine kinase activity of epidermal growth factor receptors, EGFR (or HER1), HER2 and HER4, which leads to reduced phosphorylation and activation of downstream signaling pathways.

Uses

A drug used alone or with capecitabine to treat adults with certain types of HER2-positive breast cancer that have already been treated. It is also being studied in the treatment of other types of cancer. Neratinib maleate blocks certain proteins, which may help keep cancer cells from growing and may kill them. It is a type of tyrosine kinase inhibitor.

Uses

Neratinib Maleate is a codrug; used in preparation of heterobifunctional PROTAC compounds as degraders of estrogen receptor.

Biological Activity

Neratinib is a modified form of the discontinued compound pelitinib, and was originally being develoAdditionally, phase II development of oral neratinib as a neoadjuvant therapy for breast cancer, as a second-line therapy for non-small cell lung cancer, and for other solid tumours is also in progress in numerous countries worldwide. ped by Wyeth (later Pfizer). Oral neratinib is awaiting approval as an extended adjuvant therapy for breast cancer in the EU and in the US. Blocking HER2 function by a small molecule kinase inhibitor, such as neratinib, represents an attractive alternate strategy for the growth inhibition of HER2-positive tumours.

Mechanism of action

Neratinib Maleate is the maleate salt form of neratinib, an orally available, quinazoline-based, irreversible inhibitor of both the receptor tyrosine kinases (RTKs) human epidermal growth factor receptor 2 (HER2; ERBB2) and human epidermal growth factor receptor (EGFR), with potential antineoplastic activity. Upon administration, neratinib targets and covalently binds to the cysteine residue in the ATP-binding pockets of both HER2 and EGFR. This inhibits their activity and results in the inhibition of downstream signal transduction events, induces cell cycle arrest, apoptosis and ultimately decreases cellular proliferation in HER2- and EGFR-expressing tumor cells. EGFR and HER2, RTKs that are mutated or overactivated in many tumor cell types, play key roles in tumor cell proliferation and tumor vascularization.

Neratinib Maleate Preparation Products And Raw materials

Raw materials

Preparation Products

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Neratinib Maleate Suppliers

China 114 India 4 United Kingdom 1 United States 2 Global 121

Shanghai Hansi Chemical Industry Co., Ltd.

Tel: 17717618050
Email: zllg@gh-reagent.com
Country: China
ProdList: 10424
Advantage: 58

Shanghai jing Hao pharmaceutical technology co., LTD

Tel: 021-68900963 15618693615
Fax: 021-68900963
Email: sales@jinghaopharma.com
Country: China
ProdList: 311
Advantage: 58

Arizest(Shanghai)Pharmatech Co.,Ltd

Tel: 13671599112
Email: geshi.zhuang@synovent.cn
Country: China
ProdList: 281
Advantage: 58

Taizhou Tongxin Bio-Tech Co., Ltd

Tel: 0523-18601685-898 18652728585
Email: sales@allyrise.com
Country: China
ProdList: 2741
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Porse Fine Chemical Co.,LTD

Tel: 20-66003216 18666003216
Fax: +86-20-28069063
Email: info@porsefinechemical.com
Country: China
ProdList: 2134
Advantage: 62

ChemStrong Scientific Co.,Ltd

Tel: 0755-0755-66853366 13670046396
Fax: 0755-28363542
Email: sales@chem-strong.com
Country: China
ProdList: 17994
Advantage: 56

ZHEJIANG ZETIAN FINE CHEMICALS CO.,LTD

Tel: 0571-0571-87322520/800182836 18305707819
Fax: QQ:3007632051
Email: sales@zetchem.com
Country: China
ProdList: 483
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Wuhu Nuowei Chemical Technology Co., Ltd

Tel: 0553-8233716 18055326116
Email: sales@nuowei-chem.com
Country: China
ProdList: 950
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Taizhou Ruixin Chemical Co., Ltd.

Tel: 0576-89085261 15867635987
Fax: 0576-89085262
Email: jasonhu09@163.com
Country: China
ProdList: 442
Advantage: 50

Guangzhou Qianguang Trade Co., Ltd.

Tel: 020-39071117 18030085485
Fax: 020-39071119
Email: 2797782741@qq.com
Country: China
ProdList: 292
Advantage: 55

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View Lastest Price from Neratinib Maleate manufacturers

Zibo Hangyu Biotechnology Development Co., Ltd

Product: Neratinib Maleate 915942-22-2
Price: US $75.00-750.00/KG
Min. Order: 1KG
Purity: 0.99
Supply Ability: 20 tons
Release date: 2023-10-13

Nanjing Fred Technology Co., Ltd

Product: Neratinib Maleate 915942-22-2
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99%，single impurity＜0.1
Supply Ability: 1 ton
Release date: 2023-12-22

Henan Aochuang Chemical Co.,Ltd.

Product: Neratinib Maleate 915942-22-2
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-30

915942-22-2, Neratinib MaleateRelated Search:

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Neratinib Maleate

(E)-N-[4-[3-Chloro-4-[(2-pyridinyl)methoxy]anilino]-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide maleate

2-Butenamide, N-[4-[[3-chloro-4-(2-pyridinylmethoxy)phenyl]amino]-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-, (2E)-, (2Z)-2-butenedioate (1:1)

(2E)-N-(4-{[3-Chloro-4-(2-pyridinylmethoxy)phenyl]amino}-3-cyano-7-ethoxy-6-quinolinyl)-4-(dimethylamino)-2-butenamide (2Z)-2-butenedioate (1:1)

Nerlynx

Neratinib Maleate USP/EP/BP

(E)-N-{4-[3-chloro-4-(pyridin-2-yl methoxy) anilino]-3-cyano-7-ethoxyquinolin-6-yl}-4- (dimethylamino)but-2-enamide maleate

(2E)-N-(4-{[3-Chloro-4-(2-pyridinylmethoxy)phenyl]amino}-3-c...

915942-22-2

91594-22-2

C30H29ClN6O3C4H4O4

C34H33ClN6O7