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Solithromycin

Product Name
Solithromycin
CAS No.
760981-83-7
Chemical Name
Solithromycin
Synonyms
OP 1068;CEM 101;CS-1652;SOLITHROMYCIN;Solitthromycin;CEM-101;OP-1068;Solithromycin - CEM 101 | OP 1068;Solithromycin Solithromycin Solithromycin;2H-Oxacyclotetradecino[4,3-d]oxazole-2,6,8,14(1H,7H,9H)-tetrone, 1-[4-[4-(3-aminophenyl)-1H-1,2,3-triazol-1-yl]butyl]-4-ethyl-7-fluorooctahydro-11-methoxy-3a,7,9,11,13,15-hexamethyl-10-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]-, (3aS,4R,7S,9R,10R,11R,13R,15R,15aR)-;(3aS,4R,7S,9R,10R,11R,13R,15R,15aR)-1-(4-(4-(3-Aminophenyl)-1H-1,2,3-triazol-1-yl)butyl)-10-(((2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-4-ethyl-7-fluoro-11-methoxy-3a,7,9,11,13,15-hexamethyloctahydro-1H-[1]oxacyclotetradecino[4,3-d]oxazole-2,6,8,14(7H,9H)-tetraone
CBNumber
CB22707354
Molecular Formula
C43H65FN6O10
Formula Weight
845.01
MOL File
760981-83-7.mol
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Solithromycin Property

Boiling point:
969.2±75.0 °C(Predicted)
Density 
1.30±0.1 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility 
≥34.35 mg/mL in DMSO
form 
solid
pka
13.46±0.70(Predicted)
color 
White to off-white
InChIKey
IXXFZUPTQVDPPK-UHNITVMTNA-N
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SBR00037
Product name
Solithromycin
Purity
≥98% (HPLC)
Packaging
10MG
Price
$69.4
Updated
2024/03/01
Cayman Chemical
Product number
21681
Product name
Solithromycin
Purity
≥98%
Packaging
5mg
Price
$34
Updated
2024/03/01
Cayman Chemical
Product number
21681
Product name
Solithromycin
Purity
≥98%
Packaging
10mg
Price
$65
Updated
2024/03/01
Cayman Chemical
Product number
21681
Product name
Solithromycin
Purity
≥98%
Packaging
25mg
Price
$127
Updated
2024/03/01
ChemScene
Product number
CS-5053
Product name
Solithromycin
Purity
99.97%
Packaging
10mg
Price
$150
Updated
2021/12/16
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Solithromycin Chemical Properties,Usage,Production

Pharmaceutical Applications

A 2-fluoroketolide. The side chain substituting the C11–C12 carbamate is composed of a substituted triazolyl (aminophenyl) ring. It displays good in-vitro and in-vivo activity against Streptococcus spp., including Str. pneumoniae (MIC 0.0015–0.25 mg/L), Str. pyogenes (MIC ≤0.008–0.015 mg/L)and viridians group streptococci (MIC ≤0.008–0.06 mg/L). Activity against H. influenzae is close to that of azithromycin (MIC 1.0–2.0 mg/L). Vancomycin-susceptible strains of E. faecalis are inhibited by 0.003–2.0 mg/L and E. faecium by 0.25–2.0 mg/L. It exhibits good activity against Ch. pneumoniae (MIC 0.25–1.0 mg/L), C. trachomatis (MIC 0.123–0.5 mg/L) and Mycoplasma spp. (MIC ≤0.0008 mg/L). In vitro H. pylori is susceptible (MIC 0.006–0.25 mg/L), but C. jejuni less so (MIC 1–4 mg/L). It is extremely active in vitro against B. anthracis (MIC <0.008–0.015 mg/L) and other agents of bioterrorism such as Francisella tularensis (MIC <0.08–4.0 mg/L), Yersinia pestis and Burkholderia mallei (MIC 0.25–2.0 mg/L). It exhibits a good activity against the M. avium complex.
In healthy adult volunteers the proposed therapeutic dose of 400 mg achieved a peak plasma concentration of 0.78 mg/L after 4 h. The apparent elimination half-life was 5.1 h.

Biological Activity

solithromycin (cem-101) is a new, potent and broad-spectrum fluoroketolide antibiotic [1][2].antibiotic is an antimicrobial used in the treatment and prevention of bacterial infection.solithromycin (cem-101) is a broad-spectrum fluoroketolide antibiotic. cem-101 exhibited high potency against diverse groups of gram-positive and gram-negative bacteria, including mycoplasma and ureaplasma, as well as bacteria associated with respiratory tract infections and skin infections, with mic50 values of 0.015 μg/ml and 4 μg/ml, respectively [1]. solithromycin (cem-101) bound to the large 50s subunit of the ribosome and inhibited protein biosynthesis. in streptococcus pneumoniae, staphylococcus aureus, and haemophilus influenzae, solithromycin inhibited cell viability, protein synthesis, and growth rate with ic50 values of 7.5, 40, and 125 ng/ml. solithromycin also inhibition the formation of the 50s subunit [3]. in monocytic u937 cells, solithromycin inhibited tnfα/cxcl8 production and mmp9 activity. in pbmc isolated from chronic obstructive pulmonary disease (copd) patients, solithromycin (10 μm) inhibited tnfα release and mmp9 activity. in monocytic u937 cells, solithromycin (10 μm) significantly inhibited nf-κb activity activated by oxidative stress [4].in c57bl/6j mice, solithromycin also inhibited cigarette smoke-induced neutrophilia and pro-mmp9 production [4]. cem-101 was also an effective antimicrobial for the prevention and treatment of intrauterine infection [2].

References

[1]. putnam sd, castanheira m, moet gj, et al. cem-101, a novel fluoroketolide: antimicrobial activity against a diverse collection of gram-positive and gram-negative bacteria. diagn microbiol infect dis, 2010, 66(4): 393-401.
[2]. keelan ja, kemp mw, payne ms, et al. maternal administration of solithromycin, a new, potent, broad-spectrum fluoroketolide antibiotic, achieves fetal and intra-amniotic antimicrobial protection in a pregnant sheep model. antimicrob agents chemother, 2014, 58(1): 447-454.
[3]. rodgers w, frazier ad, champney ws. solithromycin inhibition of protein synthesis and ribosome biogenesis in staphylococcus aureus, streptococcus pneumoniae, and haemophilus influenzae. antimicrob agents chemother, 2013, 57(4): 1632-1637.
[4]. kobayashi y, wada h, rossios c, et al. a novel macrolide solithromycin exerts superior anti-inflammatory effect via nf-κb inhibition. j pharmacol exp ther, 2013, 345(1): 76-84.

Solithromycin Preparation Products And Raw materials

Raw materials

Preparation Products

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Solithromycin Suppliers

Shanghai Chaolan Chemical Technology Center
Tel
021-QQ:65489617 15618227136
Fax
21-5161 9052
Email
Sales@ATKchemical.com
Country
China
ProdList
7298
Advantage
58
Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2922
Advantage
55
Chembest Research Laboratories Limited
Tel
+86-21-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6005
Advantage
61
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7552
Advantage
61
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-400-6206333 18521732826
Fax
021-50323701
Email
market@aladdin-e.com
Country
China
ProdList
25003
Advantage
65
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4861
Advantage
58
AdooQ Bioscience CHINA
Tel
025-58849295 18951903616;
Fax
025-68650336
Email
info@adooq.cn
Country
China
ProdList
2990
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60
Changsha Chenjin Chemical Technology Co.,Ltd
Tel
86-0731-84451263 15388951283 2110078799
Fax
86-0731-84451263
Email
2110078799@qq.com
Country
China
ProdList
88
Advantage
55
Hangzhou Andi Luo New Material Technology Co., Ltd.
Tel
18857166188
Fax
-
Email
andiro@163.com
Country
China
ProdList
17
Advantage
55
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696,15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4573
Advantage
55
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View Lastest Price from Solithromycin manufacturers

BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
Product
Solithromycin 760981-83-7
Price
US $0.00/g
Min. Order
1g
Purity
More Than 99%
Supply Ability
100kg/Month
Release date
2024-09-29
shandong perfect biotechnology co.ltd
Product
Solithromycin 760981-83-7
Price
US $0.00/g
Min. Order
1g
Purity
98% HPLC
Supply Ability
100kg
Release date
2023-08-14
Handan Tongyi New Material Technology Co., Ltd
Product
Solithromycin Solithromycin Solithromycin 760981-83-7
Price
US $10.00/KG
Min. Order
1KG
Purity
99
Supply Ability
500kg/month
Release date
2021-03-10

760981-83-7, SolithromycinRelated Search:


  • CEM 101
  • OP 1068
  • SOLITHROMYCIN
  • CEM-101;OP-1068
  • CS-1652
  • Solitthromycin
  • Solithromycin - CEM 101 | OP 1068
  • 2H-Oxacyclotetradecino[4,3-d]oxazole-2,6,8,14(1H,7H,9H)-tetrone, 1-[4-[4-(3-aminophenyl)-1H-1,2,3-triazol-1-yl]butyl]-4-ethyl-7-fluorooctahydro-11-methoxy-3a,7,9,11,13,15-hexamethyl-10-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]-, (3aS,4R,7S,9R,10R,11R,13R,15R,15aR)-
  • Solithromycin Solithromycin Solithromycin
  • (3aS,4R,7S,9R,10R,11R,13R,15R,15aR)-1-(4-(4-(3-Aminophenyl)-1H-1,2,3-triazol-1-yl)butyl)-10-(((2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-4-ethyl-7-fluoro-11-methoxy-3a,7,9,11,13,15-hexamethyloctahydro-1H-[1]oxacyclotetradecino[4,3-d]oxazole-2,6,8,14(7H,9H)-tetraone
  • 760981-83-7
  • 70981-83-7
  • C43H65FN6O10
  • Inhibitors