UMI-77

ChemicalBook > CAS DataBase List > UMI-77

Product Name: UMI-77
CAS No.: 518303-20-3
Chemical Name: UMI-77
Synonyms: UMI-77;CS-1799;UMI 77;UMI77;UMI-77 USP/EP/BP;Bcl-2 Family,UMI-77,Inhibitor,inhibit;2-((4-(4-Bromophenylsulfonamido)-1-hydroxynaphthalen-2-yl)thio)acetic acid;2-[[4-[[(4-bromophenyl)sulfonyl]amino]-1-hydroxy-2-naphthalenyl]thio]-acetic acid;Acetic acid, 2-[[4-[[(4-bromophenyl)sulfonyl]amino]-1-hydroxy-2-naphthalenyl]thio]-;2-[4-[(4-Bromophenyl)sulfonylamino]-1-hydroxynaphthalen-2-yl]sulfanylacetic acid UMI-77
CBNumber: CB52729658
Molecular Formula: C18H14BrNO5S2
Formula Weight: 468.34
MOL File: 518303-20-3.mol

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UMI-77 Property

Boiling point:: 661.2±65.0 °C(Predicted)
Density: 1.79±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: ≥23.4 mg/mL in DMSO; insoluble in H2O; ≥7.2 mg/mL in EtOH
form: solid
pka: 2.41±0.30(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 19148
Product name: UMI-77
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 19148
Product name: UMI-77
Purity: ≥98%
Packaging: 5mg
Price: $93
Updated: 2024/03/01

Cayman Chemical

Product number: 19148
Product name: UMI-77
Purity: ≥98%
Packaging: 10mg
Price: $169
Updated: 2024/03/01

Usbiological

Product number: 468454
Product name: UMI-77
Packaging: 1mg
Price: $382
Updated: 2021/12/16

TRC

Product number: U700850
Product name: UMI-77
Packaging: 1mg
Price: $100
Updated: 2021/12/16

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UMI-77 Chemical Properties,Usage,Production

Uses

UMI-77 acts as a small molecule inhibitor of Mcl-1 which blocks and attenuates pancreatic cell cancer growth. Anticancer agent.

Biological Activity

umi-77 is a novel small-molecule inhibitor of mcl-1 with ki and ic50 values of 0.49 μm and 0.31 μm [1].myeloid cell leukemia-1 (mcl-1) is a member of the prosurvival bcl-2 family and is a potent anti-apoptotic protein. mcl-1 acts as an important survival factor in a broad range of human cancers [1].umi-77 is a novel small-molecule mcl-1 inhibitor. in fp-based binding assays, umi-77 potently and selectively displaced fluorescent labeled bid-bh3 peptide from mcl-1 protein with ki value of 0.49μm and bound to the bh3 binding pocket of mcl-1 protein. umi-77 bound to a1/bfl-1, bcl-w, bcl-2 and bcl-xl with ki values of 5.33, 8.19, 23.83 and 32.99μm. in a pull-down assay, umi-77 at 10 μm effectively and dose-dependently inhibited the interactions between bl-noxa and cellular mcl-1. it was reported that mcl-1 regulates pro-apoptotic bax and bak proteins and preventing their pro-apoptotic activity. umi-77 dose-dependently inhibited the binding of mcl-1 to bax with ic50 value of 1.43μm. in pc cells, umi-77 inhibited cell growth and induced apoptosis in a time and dose-dependent way [1].in bxpc-3 xenografted scid mice model, umi-77 exhibited robust anti-tumor efficacy with no toxicity. also, umi-77 decreased the anti-apoptotic protein survivin, which potently inhibited apoptosis by antagonizing caspase activity [1].

References

[1]. abulwerdi f, liao c, liu m, azmi as, et al. a novel small-molecule inhibitor of mcl-1 blocks pancreatic cancer growth in vitro and in vivo. mol cancer ther, 2014, 13(3): 565-575.

UMI-77 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from UMI-77 manufacturers

Career Henan Chemical Co

Product: Acetic acid, 2-?[[4-?[[(4-?bromophenyl)?sulfonyl]?amino]?-?1-?hydroxy-?2-?naphthalenyl]?thio]?- 518303-20-3
Price: US $1.00/KG
Min. Order: 1KG
Purity: Min98% HPLC
Supply Ability: g/kg/ton
Release date: 2020-01-01

518303-20-3, UMI-77Related Search:

MK-8776 (SCH 900776) ABT-199 Panobinostat ABT 737 BI-97C1 ABT 263

2-((4-(4-Bromophenylsulfonamido)-1-hydroxynaphthalen-2-yl)thio)acetic acid

UMI-77

2-[[4-[[(4-bromophenyl)sulfonyl]amino]-1-hydroxy-2-naphthalenyl]thio]-acetic acid

2-[4-[(4-Bromophenyl)sulfonylamino]-1-hydroxynaphthalen-2-yl]sulfanylacetic acid UMI-77

Acetic acid, 2-[[4-[[(4-bromophenyl)sulfonyl]amino]-1-hydroxy-2-naphthalenyl]thio]-

UMI 77;UMI77

CS-1799

UMI-77 USP/EP/BP

Bcl-2 Family,UMI-77,Inhibitor,inhibit

518303-20-3

Inhibitors

API