ChemicalBook > CAS DataBase List > SCH900776

SCH900776

Product Name
SCH900776
CAS No.
891494-63-6
Chemical Name
SCH900776
Synonyms
SCH900776(R);SCH 900776, >=98%;SCH900776 USP/EP/BP;SCH 900776 (MK-8776);MK-8776 (SCH 900776);MK-8776 (SCH900776)(S);SCH-900776; SCH 900776; MK-8776.;SCH900776 MK-8776 SCH-900776 MK8776;Inhibitor,MK8776,Checkpoint Kinase (Chk),SCH900776,SCH-900776,inhibit,SCH 900776;6-Bromo-3-(1-methyl-1H-pyrazol-4-yl)-5-(3R)-3-piperidinylpyrazolo[1,5-a]pyrimidin-7-amine
CBNumber
CB72596614
Molecular Formula
C15H18BrN7
Formula Weight
376.25
MOL File
891494-63-6.mol
More
Less

SCH900776 Property

Density 
1.80
storage temp. 
Store at -20°C
solubility 
insoluble in H2O; insoluble in EtOH; ≥18.8 mg/mL in DMSO
form 
A crystalline solid
pka
8.88±0.10(Predicted)
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML3587
Product name
SCH 900776
Purity
≥98% (HPLC)
Packaging
5MG
Price
$99
Updated
2024/03/01
Sigma-Aldrich
Product number
SML3587
Product name
SCH 900776
Purity
≥98% (HPLC)
Packaging
25MG
Price
$399
Updated
2024/03/01
Cayman Chemical
Product number
18131
Product name
SCH 900776
Purity
≥95%
Packaging
500μg
Price
$45
Updated
2024/03/01
Cayman Chemical
Product number
18131
Product name
SCH 900776
Purity
≥95%
Packaging
1mg
Price
$72
Updated
2024/03/01
Cayman Chemical
Product number
18131
Product name
SCH 900776
Purity
≥95%
Packaging
5mg
Price
$241
Updated
2024/03/01
More
Less

SCH900776 Chemical Properties,Usage,Production

Uses

This compound acts as a novel Chk1 inhibitor acting as an anticancer agent.

Biological Activity

sch 900776 is a potent and selective inhibitor of cell cycle checkpoint kinase 1 (chk1), chk2 and cdk3 with ic50 value of 3 nm, 1.5μm and 0.16 μm, respectively.chk is s serine/threonine kinase that senses signal of dna damage and stalls dna replication, and also plays an essential role in the maintenance of replication fork viability during exposure to dna antimetabolites.in balb/c mice, administration of sch 900776 at a dosage of 8mg/kg after gemcitabine treatment can sufficiently induce enhanced tumor pharmacodynamic and regression responses as compared to gemcitabine or sch 900776 alone 1.

in vitro

sch 900776 blocked accumulation of the chk1 ps296 autophosphorylation in a dose-dependent manner. treatment of proliferating ws1 cells with sch 900776 was found to be associated with rapid, dose-dependent accumulation of chk1 ps345, indicating that cycling populations of normal cells induce chk1 ps345 in response to the inhibition of sch 900776 as part of a futile cycle 1.

References

1. guzi tj, paruch k, dwyer mp, et al. targeting the replication checkpoint using sch 900776, a potent and functionally selective chk1 inhibitor identified via high content screening. molecular cancer therapeutics. 2011;10(4):591-602.

SCH900776 Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

SCH900776 Suppliers

Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2923
Advantage
55
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Jinan Trio PharmaTech Co., Ltd.
Tel
+86 (531) 88811783
Fax
+86 (531) 55696010 QQ 1762738062
Email
sales@trio-pharmatech.com (International market)
Country
China
ProdList
1856
Advantage
62
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
sales@meilune.com
Country
China
ProdList
4647
Advantage
58
NCE Biomedical Co.,Ltd.
Tel
4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
Fax
+86-27-87599188
Country
China
ProdList
1494
Advantage
55
Shanghai T&W Pharmaceutical Co., Ltd.
Tel
+86 21 61551611
Fax
+86 21 50676805
Country
China
ProdList
9901
Advantage
58
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7553
Advantage
61
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4863
Advantage
58
Guangzhou Isun Pharmaceutical Co., Ltd
Tel
020-39119399 18927568969
Fax
020-39119999
Email
isunpharm@qq.com
Country
China
ProdList
4428
Advantage
55
AdooQ BioScience, LLC
Tel
+1 (866) 930-6790
Fax
+1 (866) 333-9607
Email
info@adooq.com
Country
United States
ProdList
2784
Advantage
58

891494-63-6, SCH900776Related Search:


  • 6-Bromo-3-(1-methyl-1H-pyrazol-4-yl)-5-(3R)-3-piperidinylpyrazolo[1,5-a]pyrimidin-7-amine
  • SCH-900776; SCH 900776; MK-8776.
  • MK-8776 (SCH 900776)
  • SCH 900776 (MK-8776)
  • SCH900776(R)
  • 6-bromo-3-(1-methyl-1H-pyrazol-4-yl)-5-((R)-piperidin-3-yl)pyrazolo[1,5-a]pyrimidin-7-amine
  • SCH 900776, >=98%
  • (R)-6-Bromo-3-(1-methyl-1H-pyrazol-4-yl)-5-(piperidin-3-yl)pyrazolo[1,5-a]pyrimidin-7-amine
  • MK-8776 (SCH900776)(S)
  • Pyrazolo[1,5-a]pyrimidin-7-amine, 6-bromo-3-(1-methyl-1H-pyrazol-4-yl)-5-(3R)-3-piperidinyl-
  • SCH900776 USP/EP/BP
  • SCH900776 MK-8776 SCH-900776 MK8776
  • Inhibitor,MK8776,Checkpoint Kinase (Chk),SCH900776,SCH-900776,inhibit,SCH 900776
  • 891494-63-6
  • C15H18BrN7
  • Inhibitors