SCH900776

Product Name: SCH900776
CAS No.: 891494-63-6
Chemical Name: SCH900776
Synonyms: SCH900776(R);SCH 900776, >=98%;SCH900776 USP/EP/BP;SCH 900776 (MK-8776);MK-8776 (SCH 900776);MK-8776 (SCH900776)(S);SCH900776, 10 mM in DMSO;MK-8776 (SCH 900776) ，S2735;SCH-900776; SCH 900776; MK-8776.;SCH900776 MK-8776 SCH-900776 MK8776
CBNumber: CB72596614
Molecular Formula: C15H18BrN7
Formula Weight: 376.25
MOL File: 891494-63-6.mol

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SCH900776 Property

Density: 1.80
storage temp.: Store at -20°C
solubility: insoluble in H2O; insoluble in EtOH; ≥18.8 mg/mL in DMSO
form: A crystalline solid
pka: 8.88±0.10(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H303May be harmfulif swallowed

H320Causes eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML3587
Product name: SCH 900776
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $96.9
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML3587
Product name: SCH 900776
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $410
Updated: 2025/07/31

Cayman Chemical

Product number: 18131
Product name: SCH 900776
Purity: ≥95%
Packaging: 500μg
Price: $45
Updated: 2024/03/01

Cayman Chemical

Product number: 18131
Product name: SCH 900776
Purity: ≥95%
Packaging: 1mg
Price: $72
Updated: 2024/03/01

Cayman Chemical

Product number: 18131
Product name: SCH 900776
Purity: ≥95%
Packaging: 5mg
Price: $241
Updated: 2024/03/01

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SCH900776 Chemical Properties,Usage,Production

Uses

This compound acts as a novel Chk1 inhibitor acting as an anticancer agent.

Biological Activity

sch 900776 is a potent and selective inhibitor of cell cycle checkpoint kinase 1 (chk1), chk2 and cdk3 with ic50 value of 3 nm, 1.5μm and 0.16 μm, respectively.chk is s serine/threonine kinase that senses signal of dna damage and stalls dna replication, and also plays an essential role in the maintenance of replication fork viability during exposure to dna antimetabolites.in balb/c mice, administration of sch 900776 at a dosage of 8mg/kg after gemcitabine treatment can sufficiently induce enhanced tumor pharmacodynamic and regression responses as compared to gemcitabine or sch 900776 alone 1.

in vitro

sch 900776 blocked accumulation of the chk1 ps296 autophosphorylation in a dose-dependent manner. treatment of proliferating ws1 cells with sch 900776 was found to be associated with rapid, dose-dependent accumulation of chk1 ps345, indicating that cycling populations of normal cells induce chk1 ps345 in response to the inhibition of sch 900776 as part of a futile cycle 1.

in vivo

SCH 900776 induces the γ-H2AX biomarker at 4 mg/kg (i.p.), and enhances tumor pharmacodynamic and regression responses in A2780 xenograft model. SCH 900776 (16 and 32 mg/kg, i.p.) induces incremental improvements in tumor response. Escalation of SCH 900776 dose to 20 and 50 mg/kg in combination with LY 188011 results in improvements in TTP 10× in the A2780 xenograft systems^[2].

IC 50

Chk1: 3 nM (IC₅₀); Chk2: 1500 nM (IC₅₀); CDK2: 160 nM (IC₅₀)

References

1. guzi tj, paruch k, dwyer mp, et al. targeting the replication checkpoint using sch 900776, a potent and functionally selective chk1 inhibitor identified via high content screening. molecular cancer therapeutics. 2011;10(4):591-602.

SCH900776 Preparation Products And Raw materials

Raw materials

Preparation Products

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SCH900776 Suppliers

Canada 1 China 102 India 1 United Kingdom 1 United States 15 Global 120

Shanghai Boyle Chemical Co., Ltd.

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Haoyuan Chemexpress Co., Ltd.

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AdooQ BioScience, LLC

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891494-63-6, SCH900776Related Search:

MK-2206 2HCl MK-4101 mk-1064 MK 0557 MK-5172 Mk-2461 . (E)-3-[[[3-[2-(7-CHLORO-2-QUINOLINYL)ETHENYL]PHENYL]-[[(3-DIMETHYLAMINO)-3-OXOPROPYL]THIO]METHYL]THIO]-PROPANOIC ACID, SODIUM SALT Omarigliptin (MK-3102) 1-Methyl-1H-pyrazole-4-boronic acid 5-Hydroxy-1-methylpyrazole 1-Methylpyrazole MK-1775 AZD7762 Alisertib (MLN8237) VE-821 CHIR-124 Olaparib MK-8998

6-Bromo-3-(1-methyl-1H-pyrazol-4-yl)-5-(3R)-3-piperidinylpyrazolo[1,5-a]pyrimidin-7-amine

SCH-900776; SCH 900776; MK-8776.

MK-8776 (SCH 900776)

SCH 900776 (MK-8776)

SCH900776(R)

6-bromo-3-(1-methyl-1H-pyrazol-4-yl)-5-((R)-piperidin-3-yl)pyrazolo[1,5-a]pyrimidin-7-amine

SCH 900776, >=98%

(R)-6-Bromo-3-(1-methyl-1H-pyrazol-4-yl)-5-(piperidin-3-yl)pyrazolo[1,5-a]pyrimidin-7-amine

MK-8776 (SCH900776)(S)

Pyrazolo[1,5-a]pyrimidin-7-amine, 6-bromo-3-(1-methyl-1H-pyrazol-4-yl)-5-(3R)-3-piperidinyl-

SCH900776 USP/EP/BP

SCH900776 MK-8776 SCH-900776 MK8776

Inhibitor,MK8776,Checkpoint Kinase (Chk),SCH900776,SCH-900776,inhibit,SCH 900776

6-Bromo-3-(1-methyl-1H-pyrazol-4-yl)-5-(3R)-3-piperidinylpyrazolo[1,5-a]pyrimidin-7-amine , SCH900776

SCH900776, 10 mM in DMSO

MK-8776 (SCH 900776) ，S2735

891494-63-6

C15H18BrN7

Inhibitors