ChemicalBook > CAS DataBase List > SCH900776

SCH900776

Product Name
SCH900776
CAS No.
891494-63-6
Chemical Name
SCH900776
Synonyms
SCH900776(R);SCH 900776, >=98%;SCH900776 USP/EP/BP;SCH 900776 (MK-8776);MK-8776 (SCH 900776);MK-8776 (SCH900776)(S);SCH-900776; SCH 900776; MK-8776.;SCH900776 MK-8776 SCH-900776 MK8776;Inhibitor,MK8776,Checkpoint Kinase (Chk),SCH900776,SCH-900776,inhibit,SCH 900776;6-Bromo-3-(1-methyl-1H-pyrazol-4-yl)-5-(3R)-3-piperidinylpyrazolo[1,5-a]pyrimidin-7-amine
CBNumber
CB72596614
Molecular Formula
C15H18BrN7
Formula Weight
376.25
MOL File
891494-63-6.mol
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SCH900776 Property

Density 
1.80
storage temp. 
Store at -20°C
solubility 
insoluble in H2O; insoluble in EtOH; ≥18.8 mg/mL in DMSO
form 
A crystalline solid
pka
8.88±0.10(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML3587
Product name
SCH 900776
Purity
≥98% (HPLC)
Packaging
5MG
Price
$99
Updated
2024/03/01
Sigma-Aldrich
Product number
SML3587
Product name
SCH 900776
Purity
≥98% (HPLC)
Packaging
25MG
Price
$399
Updated
2024/03/01
Cayman Chemical
Product number
18131
Product name
SCH 900776
Purity
≥95%
Packaging
500μg
Price
$45
Updated
2024/03/01
Cayman Chemical
Product number
18131
Product name
SCH 900776
Purity
≥95%
Packaging
1mg
Price
$72
Updated
2024/03/01
Cayman Chemical
Product number
18131
Product name
SCH 900776
Purity
≥95%
Packaging
5mg
Price
$241
Updated
2024/03/01
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SCH900776 Chemical Properties,Usage,Production

Uses

This compound acts as a novel Chk1 inhibitor acting as an anticancer agent.

Biological Activity

sch 900776 is a potent and selective inhibitor of cell cycle checkpoint kinase 1 (chk1), chk2 and cdk3 with ic50 value of 3 nm, 1.5μm and 0.16 μm, respectively.chk is s serine/threonine kinase that senses signal of dna damage and stalls dna replication, and also plays an essential role in the maintenance of replication fork viability during exposure to dna antimetabolites.in balb/c mice, administration of sch 900776 at a dosage of 8mg/kg after gemcitabine treatment can sufficiently induce enhanced tumor pharmacodynamic and regression responses as compared to gemcitabine or sch 900776 alone 1.

in vitro

sch 900776 blocked accumulation of the chk1 ps296 autophosphorylation in a dose-dependent manner. treatment of proliferating ws1 cells with sch 900776 was found to be associated with rapid, dose-dependent accumulation of chk1 ps345, indicating that cycling populations of normal cells induce chk1 ps345 in response to the inhibition of sch 900776 as part of a futile cycle 1.

References

1. guzi tj, paruch k, dwyer mp, et al. targeting the replication checkpoint using sch 900776, a potent and functionally selective chk1 inhibitor identified via high content screening. molecular cancer therapeutics. 2011;10(4):591-602.

SCH900776 Preparation Products And Raw materials

Raw materials

Preparation Products

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891494-63-6, SCH900776Related Search:

MK-2206 2HCl MK-4101 mk-1064 MK 0557 MK-5172 Mk-2461 . (E)-3-[[[3-[2-(7-CHLORO-2-QUINOLINYL)ETHENYL]PHENYL]-[[(3-DIMETHYLAMINO)-3-OXOPROPYL]THIO]METHYL]THIO]-PROPANOIC ACID, SODIUM SALT Omarigliptin (MK-3102) 1-Methyl-1H-pyrazole-4-boronic acid 5-Hydroxy-1-methylpyrazole 1-Methylpyrazole MK-1775 AZD7762 Alisertib (MLN8237) VE-821 CHIR-124 Olaparib MK-8998

  • 6-Bromo-3-(1-methyl-1H-pyrazol-4-yl)-5-(3R)-3-piperidinylpyrazolo[1,5-a]pyrimidin-7-amine
  • SCH-900776; SCH 900776; MK-8776.
  • MK-8776 (SCH 900776)
  • SCH 900776 (MK-8776)
  • SCH900776(R)
  • 6-bromo-3-(1-methyl-1H-pyrazol-4-yl)-5-((R)-piperidin-3-yl)pyrazolo[1,5-a]pyrimidin-7-amine
  • SCH 900776, >=98%
  • (R)-6-Bromo-3-(1-methyl-1H-pyrazol-4-yl)-5-(piperidin-3-yl)pyrazolo[1,5-a]pyrimidin-7-amine
  • MK-8776 (SCH900776)(S)
  • Pyrazolo[1,5-a]pyrimidin-7-amine, 6-bromo-3-(1-methyl-1H-pyrazol-4-yl)-5-(3R)-3-piperidinyl-
  • SCH900776 USP/EP/BP
  • SCH900776 MK-8776 SCH-900776 MK8776
  • Inhibitor,MK8776,Checkpoint Kinase (Chk),SCH900776,SCH-900776,inhibit,SCH 900776
  • 6-Bromo-3-(1-methyl-1H-pyrazol-4-yl)-5-(3R)-3-piperidinylpyrazolo[1,5-a]pyrimidin-7-amine , SCH900776
  • 891494-63-6
  • C15H18BrN7
  • Inhibitors