ChemicalBook > CAS DataBase List > 2-chloro-N-(3-((1,1-dioxidobenzo[d]isothiazol-3-yl)amino)phenyl)acetamide

2-chloro-N-(3-((1,1-dioxidobenzo[d]isothiazol-3-yl)amino)phenyl)acetamide

Product Name
2-chloro-N-(3-((1,1-dioxidobenzo[d]isothiazol-3-yl)amino)phenyl)acetamide
CAS No.
1449236-96-7
Chemical Name
2-chloro-N-(3-((1,1-dioxidobenzo[d]isothiazol-3-yl)amino)phenyl)acetamide
Synonyms
NMS-859, 10 mM in DMSO;2-Chloro-N-{3-[(1,1-dioxido-1,2-benzothiazol-3-yl)amino]phenyl}acetamide;2-chloro-N-(3-((1,1-dioxidobenzo[d]isothiazol-3-yl)amino)phenyl)acetamide;Acetamide, 2-chloro-N-[3-[(1,1-dioxido-1,2-benzisothiazol-3-yl)amino]phenyl]-
CBNumber
CB52738487
Molecular Formula
C15H12ClN3O3S
Formula Weight
349.79
MOL File
1449236-96-7.mol
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2-chloro-N-(3-((1,1-dioxidobenzo[d]isothiazol-3-yl)amino)phenyl)acetamide Property

Density 
1.52±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO : ≥ 42 mg/mL (120.07 mM)
form 
Solid
pka
12.40±0.70(Predicted)
color 
White to gray
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-3929
Product name
NMS-859
Purity
97.65%
Packaging
5mg
Price
$420
Updated
2021/12/16
ChemScene
Product number
CS-3929
Product name
NMS-859
Purity
97.65%
Packaging
10mg
Price
$600
Updated
2021/12/16
ChemScene
Product number
CS-3929
Product name
NMS-859
Purity
97.65%
Packaging
50mg
Price
$1800
Updated
2021/12/16
ChemScene
Product number
CS-3929
Product name
NMS-859
Purity
97.65%
Packaging
100mg
Price
$2520
Updated
2021/12/16
Crysdot
Product number
CD31003439
Product name
NMS-859
Purity
98+%
Packaging
5mg
Price
$243
Updated
2021/12/16
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2-chloro-N-(3-((1,1-dioxidobenzo[d]isothiazol-3-yl)amino)phenyl)acetamide Chemical Properties,Usage,Production

Uses

NMS-859 is a potent, covalent VCP (p97) inhibitor, with IC50s of 0.37 and 0.36 μM for wild-type VCP in the presence of 60 μM and 1 mM ATP in cells, respectively.

References

[1] Magnaghi P, et al. Covalent and allosteric inhibitors of the ATPase VCP/p97 induce cancer cell death. Nat Chem Biol. 2013 Sep;9(9):548-56. DOI:10.1038/nchembio.1313

2-chloro-N-(3-((1,1-dioxidobenzo[d]isothiazol-3-yl)amino)phenyl)acetamide Preparation Products And Raw materials

Raw materials

Preparation Products

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2-chloro-N-(3-((1,1-dioxidobenzo[d]isothiazol-3-yl)amino)phenyl)acetamide Suppliers

China 30 United States 7 Global 37
MedChemexpress LLC
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021-58955995
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sales@medchemexpress.cn
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United States
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Musechem
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+1-800-259-7612
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+1-800-259-7612
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+1-781-999-5354; +17819995354
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marketing@targetmol.com
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United States
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TargetMol Chemicals Inc.
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+1-781-999-5354;
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support@targetmol.com
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Aladdin Scientific
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MedChemExpress
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Combi-Blocks Inc.
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1449236-96-7, 2-chloro-N-(3-((1,1-dioxidobenzo[d]isothiazol-3-yl)amino)phenyl)acetamideRelated Search:


  • 2-chloro-N-(3-((1,1-dioxidobenzo[d]isothiazol-3-yl)amino)phenyl)acetamide
  • 2-Chloro-N-{3-[(1,1-dioxido-1,2-benzothiazol-3-yl)amino]phenyl}acetamide
  • Acetamide, 2-chloro-N-[3-[(1,1-dioxido-1,2-benzisothiazol-3-yl)amino]phenyl]-
  • NMS-859, 10 mM in DMSO
  • 1449236-96-7