4-Bromo-2-fluoro-3-methylbenzonitrile
- Product Name
- 4-Bromo-2-fluoro-3-methylbenzonitrile
- CAS No.
- 1114546-30-3
- Chemical Name
- 4-Bromo-2-fluoro-3-methylbenzonitrile
- Synonyms
- 4-Bromo-2-fluoro-3-methylbenzonitrile;Benzonitrile, 4-bromo-2-fluoro-3-methyl-;4-bromo-2-fluoro-3-methylbenzene-1-carbonitrile
- CBNumber
- CB52742059
- Molecular Formula
- C8H5BrFN
- Formula Weight
- 214.03
- MOL File
- 1114546-30-3.mol
4-Bromo-2-fluoro-3-methylbenzonitrile Property
- Boiling point:
- 259.6±35.0 °C(Predicted)
- Density
- 1.59±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- form
- crystalline powder
- color
- Wooly, light pinkish peach
Safety
- HS Code
- 2926907090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B679505
- Product name
- 4-Bromo-2-fluoro-3-methylbenzonitrile
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- PC48590
- Product name
- 4-Bromo-2-fluoro-3-methylbenzonitrile
- Packaging
- 250mg
- Price
- $163
- Updated
- 2021/12/16
- Product number
- 3737-B-00
- Product name
- 4-Bromo-2-fluoro-3-methylbenzonitrile
- Packaging
- 250mg
- Price
- $192
- Updated
- 2021/12/16
- Product number
- PC48590
- Product name
- 4-Bromo-2-fluoro-3-methylbenzonitrile
- Packaging
- 1g
- Price
- $378
- Updated
- 2021/12/16
- Product number
- 3737-B-00
- Product name
- 4-Bromo-2-fluoro-3-methylbenzonitrile
- Packaging
- 1g
- Price
- $448
- Updated
- 2021/12/16
4-Bromo-2-fluoro-3-methylbenzonitrile Chemical Properties,Usage,Production
Synthesis
757247-93-1
1114546-30-3
Using 4-amino-2-fluoro-3-methylbenzonitrile (10 g, 66.6 mmol) as starting material, potassium nitrite (22.67 g, 266 mmol) and copper (I) bromide (1.911 g, 13.32 mmol) were dissolved in dimethyl sulfoxide (400 mL). Subsequently, 48% aqueous hydrogen bromide solution (33 mL, 266 mmol) diluted with dimethyl sulfoxide (200 mL) was added dropwise and the reaction mixture was stirred for 2 hours. Upon completion of the reaction, complete conversion of the feedstock was confirmed by thin layer chromatography (TLC) monitoring. The reaction mixture was slowly poured into ice-cold water and neutralized with cold concentrated sodium hydroxide solution to pH 7. The precipitated solid was collected by filtration to afford the target product 4-bromo-2-fluoro-3-methylbenzonitrile (11.4 g, 53.3 mmol, 80% yield) as a white solid. The product was characterized by 1H NMR (400 MHz, CDCl3): δ 7.47 (d, J = 9.37 Hz, 1H), 7.33 (t, 1H), 2.39 (d, J = 2.34 Hz, 3H).
References
[1] Patent: WO2010/62571, 2010, A1. Location in patent: Page/Page column 128
4-Bromo-2-fluoro-3-methylbenzonitrile Preparation Products And Raw materials
Raw materials
Preparation Products
4-Bromo-2-fluoro-3-methylbenzonitrile Suppliers
- Tel
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- sales@apolloscientific.co.uk
- Country
- United Kingdom
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