MCC950

ChemicalBook > CAS DataBase List > MCC950

Product Name: MCC950
CAS No.: 210826-40-7
Chemical Name: MCC950
Synonyms: CP-456773;CRID3;CRID 3;MCC950;CRID-3;CS-2292;MCC950 (MCC-950;1-(1,2,3,5,6,7-hexahydro-s-indacen-4-yl)-3-[4-(2-hydroxypropan-2-yl)furan-2-yl]sulfonylurea;N-((1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)carbamoyl)-4-(2-hydroxypropan-2-yl)furan-2-sulfonamid;N-((1,2,3,5,6,7-hexahydro-s-indacen-4-yl)carbamoyl)-4-(2-hydroxypropan-2-yl)furan-2-sulfonamide
CBNumber: CB52744215
Molecular Formula: C20H24N2O5S
Formula Weight: 404.48
MOL File: 210826-40-7.mol

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MCC950 Property

Melting point:: 239 °C
Density: 1.396±0.06 g/cm3(Predicted)
storage temp.: -20°C
solubility: Soluble in DMSO (up to 40 mg/ml) or in Water (up to 30 mg/ml)
form: solid
pka: 4.74±0.10(Predicted)
color: White
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 1 month.

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 17510
Product name: MCC950
Purity: ≥98%
Packaging: 1mg
Price: $81
Updated: 2024/03/01

Cayman Chemical

Product number: 17510
Product name: MCC950
Purity: ≥98%
Packaging: 5mg
Price: $336
Updated: 2024/03/01

Cayman Chemical

Product number: 17510
Product name: MCC950
Purity: ≥98%
Packaging: 10mg
Price: $593
Updated: 2024/03/01

Cayman Chemical

Product number: 17510
Product name: MCC950
Purity: ≥98%
Packaging: 25mg
Price: $1184
Updated: 2024/03/01

TRC

Product number: M199775
Product name: MCC-950
Packaging: 10mg
Price: $425
Updated: 2021/12/16

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MCC950 Chemical Properties,Usage,Production

Description

MCC-950 (210826-40-7) was originally found to act as a cytokine release inhibitory drug (CRID), arresting activated monocytes and preventing activation of caspase-1.1?Discovered to be a novel inhibitor of the NLRP3 and AIM2 inflammasomes.2?MCC-950 blocks canonical and noncanonical NLRP3 activation at nanomolar concentrations.3?Inhibits interleukin 1β (IL-1β) secretion?in vivo?and attenuates the severity of experimental autoimmune encephalomyelitis (an MS disease model).3?Disrupts the interaction between AIM2 and ASC in a reconstituted cell-free inflammasome.4?MCC-950 is a valuable new tool for exploring the pathophysiology of NLRP3.

Uses

MCC950 selectively inhibits pyrin domain-containing protein 3 (NLRP3) inflammasome, a protein complex involved in the inflammatory process (1). The NLRP3 inflammasome is related to a wide range of immune disorders such as multiple sclerosis, inflammatory bowel disease, auto-immune and auto-inflammatory diseases (2). MCC950 has been shown to specifically inhibit the activation of NLRP3 but not the AIM2, NLRC4 or NLRP1 inflammasomes (1). MCC950 is a potential therapeutic for NLRP3-associated syndromes.

References

1) Laliberte?et al.?(2003),?Glutathione s-transferase omega 1-1 is a target of cytokine release inhibitory drugs and may be responsible for their effect on interleukin-1beta posttranslational processing; J. Biol. Chem.,?278?16567 2) Coll?et al. (2011),?The cytokine release inhibitory drug CRID3 targets ASC oligomerisation in the NLRP3 and AIM2 inflammasomes; Clin. PLoS One,?6(12)?e29539 3) Coll?et al.?(2015),?A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory disease; Nat. Med.,?21?248 4) Kaneko?et al.?(2015),?Reconstituted AIM2 inflammasome in cell-free system; J. Immunol. Methods,?426?76

MCC950 Preparation Products And Raw materials

Raw materials

Preparation Products

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210826-40-7, MCC950Related Search:

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N-((1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)carbamoyl)-4-(2-hydroxypropan-2-yl)furan-2-sulfonamid

MCC950

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N-[[(1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)amino]carbonyl]-4-(1-hydroxy-1-methylethyl)-2-furansulfonamChemicalbookide

CRID 3

CRID3

CRID-3

210826-40-7

21086-40-7