17-GMP-APA-GA

17-GMP-APA-GA Property

storage temp. 

-20°

solubility 

Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 10 mg/ml).

form 

solid

color 

Purple

Stability:

Stable for 2 years from date of purchase as supplied. Solutions are not stable and must be made fresh and used within 1 working day.

Hazard and Precautionary Statements (GHS)

17-GMP-APA-GA Chemical Properties,Usage,Production

Description

17-GMP-APA-GA is an analog of geldanamycin (Cat.# 10-1084) equipped with linker for coupling to proteins or antibodies for the preparation of immunoconjugates, for example.

Uses

17-GMP-APA-GA is an analog of geldanamycin(G304500) with modified linker for coupling proteins/antibodies for the preparation of immunoconjugates.

References

[1] RAYA MANDLER. Herceptin-geldanamycin immunoconjugates: pharmacokinetics, biodistribution, and enhanced antitumor activity.[J]. Cancer research, 2004, 64 4: 1460-1467. DOI:10.1158/0008-5472.can-03-2485
[2] RAYA MANDLER. Modifications in Synthesis Strategy Improve the Yield and Efficacy of Geldanamycin−Herceptin Immunoconjugates[J]. Bioconjugate Chemistry Bioconjugate, 2002, 13 4: 786-791. DOI:10.1021/bc010124g
[3] R MANDLER. Immunoconjugates of geldanamycin and anti-HER2 monoclonal antibodies: antiproliferative activity on human breast carcinoma cell lines.[J]. JNCI Journal of the National Cancer Institute, 2000, 92 19: 1573-1581. DOI:10.1093/jnci/92.19.1573