6-amino-4-(2,5-dimethoxyphenyl)-1,4-dihydro-3-(2-naphthalenyl)-pyrano[2,3-c]pyrazole-5-carbonitrile

Product Name: 6-amino-4-(2,5-dimethoxyphenyl)-1,4-dihydro-3-(2-naphthalenyl)-pyrano[2,3-c]pyrazole-5-carbonitrile
CAS No.: 361185-42-4
Chemical Name: 6-amino-4-(2,5-dimethoxyphenyl)-1,4-dihydro-3-(2-naphthalenyl)-pyrano[2,3-c]pyrazole-5-carbonitrile
Synonyms: RBC8;CS-2130;CS-2174;RBC8, >98%;RBC-8;RBC 8;RBC8 ，S7606;RBC8, 10 mM in DMSO;Inhibitor,RBC 8,Ras,inhibit,RBC8,RBC-8;6-amino-4-(2,5-dimethoxyphenyl)-1,4-dihydro-3-(2-naphthalenyl)-pyrano[2,3-c]pyrazole-5-carbonitrile;6-amino-4-(2,4-dimethoxyphenyl)-3-(naphthalen-2-yl)-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile
CBNumber: CB52744624
Molecular Formula: C25H20N4O3
Formula Weight: 424.45
MOL File: 361185-42-4.mol

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6-amino-4-(2,5-dimethoxyphenyl)-1,4-dihydro-3-(2-naphthalenyl)-pyrano[2,3-c]pyrazole-5-carbonitrile Property

Boiling point:: 701.9±60.0 °C(Predicted)
Density: 1.40±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: solid
pka: 10.51±0.70(Predicted)
color: White

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1295
Product name: RBC8
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $97.85
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML1295
Product name: RBC8
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $404
Updated: 2025/07/31

Cayman Chemical

Product number: 21281
Product name: RBC8
Purity: ≥98%
Packaging: 1mg
Price: $38
Updated: 2024/03/01

Cayman Chemical

Product number: 21281
Product name: RBC8
Purity: ≥98%
Packaging: 5mg
Price: $104
Updated: 2024/03/01

Cayman Chemical

Product number: 21281
Product name: RBC8
Purity: ≥98%
Packaging: 10mg
Price: $184
Updated: 2024/03/01

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6-amino-4-(2,5-dimethoxyphenyl)-1,4-dihydro-3-(2-naphthalenyl)-pyrano[2,3-c]pyrazole-5-carbonitrile Chemical Properties,Usage,Production

Uses

RBC8 is a RalA and RalB inhibitor of the GTPase enzyme, inhibiting binding of Ral to TaLBP1. Used in the treatment and suppression of xenograft tumors, shown in mice.

Biological Activity

rbc8 inhibit ral gtpase with ic50 values of 3.5 μm and 3.4 μm in ral-dependent lines h2122 and h358 [1].rala and b are ras-like gtpases. they are important drivers of metastasis and tumor growth [1].rbc8 reduced the activation of rala in living cells. ral is required for spreading murine embryonic fibroblasts (mefs) and lipid raft exocytosis on fibronectin-coated cover slips. in these cells, the spreading of wt mefs was inhibited by the depletion of rala via sirna, whereas caveolin deficient (cav1-/-) mefs were resistant to rala depletion. treatment with rbc8 inhibited only the cell spreading in the wt mefs, it did not inhibited the cell spreading in cav1-/- mefs. a ral pull-down assay showed that rbc8 inhibited the activation of both rala and ralb in both the h2122 and h358 cell lines. in h2122 and h358 cells with ral knockdown by sirna, treatment with rbc8 did not show further inhibition of colony formation [1].in nude mice inoculated with h2122 human lung cancer cells subcutaneously, treatment with rbc8 at 50 mg/kg/d for 21 days (except weekends) intraperitoneally showed an inhibitory effect on tumor growth to a similar extent as dual knockdown of rala and b. h358 is a lung cancer line. in this cell line, similar results were yielded [1].

in vivo

RBC8 (50 mg/kg; i.p.; daily (except weekends); 21 days) inhibits tumor growth in nude mice inoculated with H2122 and H358 human lung cancer cells^[2].

Animal Model:	Female athymic nude mice (Ncr nu/nu; 5 - 6 weeks old, weight not specified) inoculated with H2122 or H358 human lung cancer cells^[2].
Dosage:	50 mg/kg (dissolved in DMSO)
Administration:	Intraperitoneal injection, daily except weekends, for 21 days
Result:	Inhibited the growth of xenograft tumors in nude mice inoculated with H2122 cells, and the effect was similar to that of dual knockdown of RalA and RalB. Inhibited the growth of xenograft tumors in nude mice inoculated with H358 cells.

storage

Store at -20°C

References

[1]. yan c, liu d, li l, et al. discovery and characterization of small molecules that target the ral gtpase. nature, 2014, 515(7527): 443-447.

6-amino-4-(2,5-dimethoxyphenyl)-1,4-dihydro-3-(2-naphthalenyl)-pyrano[2,3-c]pyrazole-5-carbonitrile Preparation Products And Raw materials

Raw materials

Preparation Products

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6-amino-4-(2,5-dimethoxyphenyl)-1,4-dihydro-3-(2-naphthalenyl)-pyrano[2,3-c]pyrazole-5-carbonitrile Suppliers

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View Lastest Price from 6-amino-4-(2,5-dimethoxyphenyl)-1,4-dihydro-3-(2-naphthalenyl)-pyrano[2,3-c]pyrazole-5-carbonitrile manufacturers

Career Henan Chemica Co

Product: RBC8 361185-42-4
Price: US $1.00/g
Min. Order: 1g
Purity: MIn98% HPLC/LC
Supply Ability: 100KGS
Release date: 2020-10-28

361185-42-4, 6-amino-4-(2,5-dimethoxyphenyl)-1,4-dihydro-3-(2-naphthalenyl)-pyrano[2,3-c]pyrazole-5-carbonitrileRelated Search:

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6-amino-4-(2,5-dimethoxyphenyl)-1,4-dihydro-3-(2-naphthalenyl)-pyrano[2,3-c]pyrazole-5-carbonitrile

RBC8

CS-2174

CS-2130

RBC8, >98%

6-amino-4-(2,4-dimethoxyphenyl)-3-(naphthalen-2-yl)-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile

<br>6-Amino-4-(2,5-dimethoxyphenyl)-3-(naphthalen-2-yl)-1,4-dihydropyrano[2,3-c ]pyrazole-5-carbonitrile

RBC-8;RBC 8

6-amino-4-(2,5-dimethoxyphenyl)-3-(naphthalen-2-yl)-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile

Pyrano[2,3-c]pyrazole-5-carbonitrile, 6-amino-4-(2,5-dimethoxyphenyl)-1,4-dihydro-3-(2-naphthalenyl)-

Inhibitor,RBC 8,Ras,inhibit,RBC8,RBC-8

RBC8, 10 mM in DMSO

RBC8 ，S7606

361185-42-4

Inhibitors