6-amino-4-(2,5-dimethoxyphenyl)-1,4-dihydro-3-(2-naphthalenyl)-pyrano[2,3-c]pyrazole-5-carbonitrile

Product Name: 6-amino-4-(2,5-dimethoxyphenyl)-1,4-dihydro-3-(2-naphthalenyl)-pyrano[2,3-c]pyrazole-5-carbonitrile
CAS No.: 361185-42-4
Chemical Name: 6-amino-4-(2,5-dimethoxyphenyl)-1,4-dihydro-3-(2-naphthalenyl)-pyrano[2,3-c]pyrazole-5-carbonitrile
Synonyms: RBC8;CS-2130;CS-2174;RBC8, >98%;RBC-8;RBC 8;RBC8, 10 mM in DMSO;Inhibitor,RBC 8,Ras,inhibit,RBC8,RBC-8;6-amino-4-(2,5-dimethoxyphenyl)-1,4-dihydro-3-(2-naphthalenyl)-pyrano[2,3-c]pyrazole-5-carbonitrile;6-amino-4-(2,4-dimethoxyphenyl)-3-(naphthalen-2-yl)-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile;6-amino-4-(2,5-dimethoxyphenyl)-3-(naphthalen-2-yl)-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile
CBNumber: CB52744624
Molecular Formula: C25H20N4O3
Formula Weight: 424.45
MOL File: 361185-42-4.mol

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6-amino-4-(2,5-dimethoxyphenyl)-1,4-dihydro-3-(2-naphthalenyl)-pyrano[2,3-c]pyrazole-5-carbonitrile Property

Boiling point:: 701.9±60.0 °C(Predicted)
Density: 1.40±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: solid
pka: 10.51±0.70(Predicted)
color: White

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 21281
Product name: RBC8
Purity: ≥98%
Packaging: 1mg
Price: $38
Updated: 2024/03/01

Cayman Chemical

Product number: 21281
Product name: RBC8
Purity: ≥98%
Packaging: 5mg
Price: $104
Updated: 2024/03/01

Cayman Chemical

Product number: 21281
Product name: RBC8
Purity: ≥98%
Packaging: 10mg
Price: $184
Updated: 2024/03/01

Cayman Chemical

Product number: 21281
Product name: RBC8
Purity: ≥98%
Packaging: 25mg
Price: $401
Updated: 2024/03/01

Tocris

Product number: 5411
Product name: RBC8
Purity: ≥98%(HPLC)
Packaging: 10
Price: $249
Updated: 2021/12/16

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6-amino-4-(2,5-dimethoxyphenyl)-1,4-dihydro-3-(2-naphthalenyl)-pyrano[2,3-c]pyrazole-5-carbonitrile Chemical Properties,Usage,Production

Uses

RBC8 is a RalA and RalB inhibitor of the GTPase enzyme, inhibiting binding of Ral to TaLBP1. Used in the treatment and suppression of xenograft tumors, shown in mice.

Biological Activity

rbc8 inhibit ral gtpase with ic50 values of 3.5 μm and 3.4 μm in ral-dependent lines h2122 and h358 [1].rala and b are ras-like gtpases. they are important drivers of metastasis and tumor growth [1].rbc8 reduced the activation of rala in living cells. ral is required for spreading murine embryonic fibroblasts (mefs) and lipid raft exocytosis on fibronectin-coated cover slips. in these cells, the spreading of wt mefs was inhibited by the depletion of rala via sirna, whereas caveolin deficient (cav1-/-) mefs were resistant to rala depletion. treatment with rbc8 inhibited only the cell spreading in the wt mefs, it did not inhibited the cell spreading in cav1-/- mefs. a ral pull-down assay showed that rbc8 inhibited the activation of both rala and ralb in both the h2122 and h358 cell lines. in h2122 and h358 cells with ral knockdown by sirna, treatment with rbc8 did not show further inhibition of colony formation [1].in nude mice inoculated with h2122 human lung cancer cells subcutaneously, treatment with rbc8 at 50 mg/kg/d for 21 days (except weekends) intraperitoneally showed an inhibitory effect on tumor growth to a similar extent as dual knockdown of rala and b. h358 is a lung cancer line. in this cell line, similar results were yielded [1].

storage

Store at -20°C

References

[1]. yan c, liu d, li l, et al. discovery and characterization of small molecules that target the ral gtpase. nature, 2014, 515(7527): 443-447.

6-amino-4-(2,5-dimethoxyphenyl)-1,4-dihydro-3-(2-naphthalenyl)-pyrano[2,3-c]pyrazole-5-carbonitrile Preparation Products And Raw materials

Raw materials

Preparation Products

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6-amino-4-(2,5-dimethoxyphenyl)-1,4-dihydro-3-(2-naphthalenyl)-pyrano[2,3-c]pyrazole-5-carbonitrile Suppliers

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View Lastest Price from 6-amino-4-(2,5-dimethoxyphenyl)-1,4-dihydro-3-(2-naphthalenyl)-pyrano[2,3-c]pyrazole-5-carbonitrile manufacturers

Career Henan Chemica Co

Product: RBC8 361185-42-4
Price: US $1.00/g
Min. Order: 1g
Purity: MIn98% HPLC/LC
Supply Ability: 100KGS
Release date: 2020-10-28

361185-42-4, 6-amino-4-(2,5-dimethoxyphenyl)-1,4-dihydro-3-(2-naphthalenyl)-pyrano[2,3-c]pyrazole-5-carbonitrileRelated Search:

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6-amino-4-(2,5-dimethoxyphenyl)-1,4-dihydro-3-(2-naphthalenyl)-pyrano[2,3-c]pyrazole-5-carbonitrile

RBC8

CS-2174

CS-2130

RBC8, >98%

6-amino-4-(2,4-dimethoxyphenyl)-3-(naphthalen-2-yl)-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile

<br>6-Amino-4-(2,5-dimethoxyphenyl)-3-(naphthalen-2-yl)-1,4-dihydropyrano[2,3-c ]pyrazole-5-carbonitrile

RBC-8;RBC 8

6-amino-4-(2,5-dimethoxyphenyl)-3-(naphthalen-2-yl)-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile

Pyrano[2,3-c]pyrazole-5-carbonitrile, 6-amino-4-(2,5-dimethoxyphenyl)-1,4-dihydro-3-(2-naphthalenyl)-

Inhibitor,RBC 8,Ras,inhibit,RBC8,RBC-8

RBC8, 10 mM in DMSO

361185-42-4

Inhibitors