4-Chloro-5-fluoro-2-hydroxy-benzaldehyde
- Product Name
- 4-Chloro-5-fluoro-2-hydroxy-benzaldehyde
- CAS No.
- 1205551-36-5
- Chemical Name
- 4-Chloro-5-fluoro-2-hydroxy-benzaldehyde
- Synonyms
- 4-chloro-5-fluoro-2-hydroxybenzladehyde;4-Chloro-5-fluoro-2-hydroxy-benzaldehyde;Benzaldehyde, 4-chloro-5-fluoro-2-hydroxy-
- CBNumber
- CB52746486
- Molecular Formula
- C7H4ClFO2
- Formula Weight
- 174.56
- MOL File
- 1205551-36-5.mol
4-Chloro-5-fluoro-2-hydroxy-benzaldehyde Property
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- Appearance
- Light yellow to yellow Solid
Safety
- HS Code
- 2913000090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 2615-7-37
- Product name
- 4-Chloro-5-fluoro-2-hydroxybenzaldehyde
- Purity
- 96%
- Packaging
- 250mg
- Price
- $149
- Updated
- 2021/12/16
- Product number
- PC909159
- Product name
- 4-Chloro-5-fluoro-2-hydroxybenzaldehyde
- Purity
- 97%
- Packaging
- 250mg
- Price
- $93
- Updated
- 2021/12/16
- Product number
- 2773AJ
- Product name
- 4-Chloro-5-fluoro-2-hydroxy-benzaldehyde
- Packaging
- 5g
- Price
- $1265
- Updated
- 2021/12/16
- Product number
- CD12174012
- Product name
- 4-Chloro-5-fluoro-2-hydroxybenzaldehyde
- Purity
- 97%
- Packaging
- 10g
- Price
- $1386
- Updated
- 2021/12/16
- Product number
- A219416
- Product name
- 4-Chloro-5-fluoro-2-hydroxybenzaldehyde
- Purity
- 97%
- Packaging
- 10g
- Price
- $1454
- Updated
- 2021/12/16
4-Chloro-5-fluoro-2-hydroxy-benzaldehyde Chemical Properties,Usage,Production
Synthesis
100-97-0
2613-23-2
1205551-36-5
The general procedure for the synthesis of 4-chloro-5-fluoro-2-hydroxybenzaldehyde from hexamethylenetetetramine (210 g, 1.5 mol) and 3-chloro-4-fluorophenol (210 g, 1.43 mol) was as follows: hexamethylenetetetramine was added to trifluoroacetic acid (3.6 L) in small portions, and the resulting mixture was heated to reflux at 78 °C. Subsequently, a solution of 3-chloro-4-fluorophenol in trifluoroacetic acid (1.4 L) was slowly added dropwise, and stirring of the reaction mixture was continued for 1 hour after completion of the addition. After completion of the reaction, the mixture was cooled to room temperature and concentrated under vacuum. The concentrated residue was poured into ice water (2 L) and stirred overnight. The mixture was filtered, the filter cake was collected and dissolved in ethyl acetate (500 mL), dried with magnesium sulfate and concentrated again under vacuum. The crude product was washed with a solvent mixture of ethyl acetate/petroleum ether (10:1, v/v) to give the final 4-chloro-5-fluoro-2-hydroxybenzaldehyde as a white solid with a yield of 56.5 g in 23%. The product was characterized by 1H NMR (400 MHz, CDCl3) with chemical shifts of δ = 7.00-7.01 (m, 1H), 7.19-7.26 (m, 1H), 9.75 (s, 1H), 10.82 (s, 1H) ppm.
References
[1] Patent: US2010/16366, 2010, A1. Location in patent: Page/Page column 14
[2] Patent: WO2010/7561, 2010, A1. Location in patent: Page/Page column 26-27
4-Chloro-5-fluoro-2-hydroxy-benzaldehyde Preparation Products And Raw materials
Raw materials
Preparation Products
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