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INDY

Product Name
INDY
CAS No.
1169755-45-6
Chemical Name
INDY
Synonyms
INDY;CID 69538603;INDY, 10 mM in DMSO;INDY, DYRK1A/B inhibitor;(1Z)-1-(3-Ethyl-5-hydroxy-1,3-benzothiazol-2(3H)-ylidene)acetone;(1Z)-1-(3-Ethyl-5-hydroxy-2(3H)-benzothiazolylidene)-2-propanone;(1Z)-1-(3-ethyl-5-hydroxy-1,3-benzothiazol-2-ylidene)propan-2-one;(Z)-1-(3-Ethyl-5-hydroxybenzo[d]thiazol-2(3H)-ylidene)propan-2-one;2-Propanone, 1-(3-ethyl-5-hydroxy-2(3H)-benzothiazolylidene)-, (1Z)-;(1Z)-1-(3-ethyl-5-hydroxy-1,3-benzothiazol-2(3H)-ylidene)-2-propanone
CBNumber
CB52748091
Molecular Formula
C12H13NO2S
Formula Weight
235.3
MOL File
1169755-45-6.mol
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INDY Property

Boiling point:
409.2±45.0 °C(Predicted)
Density 
1.337±0.06 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
DMSO: soluble5mg/mL, clear (warmed)
form 
powder
pka
9.67±0.20(Predicted)
color 
white to beige
InChI
1S/C12H13NO2S/c1-3-13-10-7-9(15)4-5-11(10)16-12(13)6-8(2)14/h4-7,15H,3H2,1-2H3/b12-6+
InChIKey
GCSZJMUFYOAHFY-WUXMJOGZSA-N
SMILES
S1c2c(cc(cc2)O)N(\C\1=C/C(=O)C)CC
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Safety

WGK Germany 
3
Storage Class
11 - Combustible Solids
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML1011
Product name
INDY
Purity
≥98% (HPLC)
Packaging
5mg
Price
$114
Updated
2026/03/19
Sigma-Aldrich
Product number
SML1011
Product name
INDY
Purity
≥98% (HPLC)
Packaging
25mg
Price
$368
Updated
2026/03/19
Cayman Chemical
Product number
23895
Product name
INDY
Purity
≥98%
Packaging
1mg
Price
$30
Updated
2024/03/01
Cayman Chemical
Product number
23895
Product name
INDY
Purity
≥98%
Packaging
5mg
Price
$75
Updated
2024/03/01
Cayman Chemical
Product number
23895
Product name
INDY
Purity
≥98%
Packaging
10mg
Price
$134
Updated
2024/03/01
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INDY Chemical Properties,Usage,Production

Description

INDY is an ATP-competitive inhibitor of dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A (DYRK1A; Ki = 180 nM; IC50 = 240 nM). It is selective for DYRK1A over monoamine oxidase (MAO) A and B at concentrations up to 100 μM. INDY inhibits DYRK1A phosphorylation of tau in COS-7 cells expressing EGFP-DYRK1A and EGFP-tau in a concentration-dependent manner. It also restores signaling through nuclear factory of activated T cells (NFAT) and NFAT-dependent transcription in HEK293 cells overexpressing DYRK1A. In vivo, INDY reverses developmental deformities induced by DYRK1A overexpression in X. laevis embryos. INDY also induces proliferation of human and rat β-cells and increases insulin secretion by human islets in vitro.

Uses

INDY is a dual-specificity tyrosine-(Y)-phosphorylation-regulated kinase 1A/B (DYRK1A/B) inhibitor (1,2).

in vivo

ProINDY (2.5 μM) recoveres apparently normal development of the Xenopus embryo[1].

IC 50

DYRK1A; DYRK1B

storage

-20°C

References

[1] YASUSHI OGAWA. Development of a novel selective inhibitor of the Down syndrome-related kinase Dyrk1A[J]. Nature Communications, 2010, 1 1: 1-9. DOI: 10.1038/ncomms1090
[2] PENG WANG. A high-throughput chemical screen reveals that harmine-mediated inhibition of DYRK1A increases human pancreatic beta cell replication[J]. Nature Medicine, 2015, 21 4: 383-388. DOI: 10.1038/nm.3820

INDY Preparation Products And Raw materials

Raw materials

Preparation Products

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INDY Suppliers

China 71 United Kingdom 1 United States 10 Global 82
SHANGHAI FORTUNE CHEMICAL TECHNOLOGY CO., LTD
Tel
13816107857
Fax
qq: 276312098
Email
sales@fortunechem-sh.com
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China
ProdList
984
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58
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4817
Advantage
55
Guangzhou Zhiya Chemdrugs Co.,Ltd
Tel
18122150900
Fax
QQ:2869377561
Email
sculk28@163.com
Country
China
ProdList
646
Advantage
55
EMMX Biotechnology LLC
Tel
888-539-0666
Fax
888-539-0666
Email
info@emmx.com
Country
United States
ProdList
8447
Advantage
60
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
Advantage
58
TaiChem Taizhou Limited
Tel
052386810091
Email
zcwy9518@yeah.net
Country
China
ProdList
3917
Advantage
58
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
86249
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60
Shanghai Changyan Chem & Tech Co., Ltd.
Tel
18930833303 18930833303
Fax
+86 (21) 2024-2659
Email
sales@changyanchem.cn
Country
China
ProdList
5001
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55
Shanghai Rechem science Co., Ltd.
Tel
021-31433387 15618786686
Fax
QQ:1369748377
Email
sales@rechemscience.com
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China
ProdList
2990
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58
Shanghai Chaolan Chemical Technology Center
Tel
021-QQ：65489617 15618227136
Fax
21-5161 9052
Email
Sales@ATKchemical.com
Country
China
ProdList
9505
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58

1169755-45-6, INDYRelated Search:


  • INDY
  • (1Z)-1-(3-Ethyl-5-hydroxy-2(3H)-benzothiazolylidene)-2-propanone
  • (1Z)-1-(3-Ethyl-5-hydroxy-1,3-benzothiazol-2(3H)-ylidene)acetone
  • (1Z)-1-(3-ethyl-5-hydroxy-1,3-benzothiazol-2-ylidene)propan-2-one
  • 2-Propanone, 1-(3-ethyl-5-hydroxy-2(3H)-benzothiazolylidene)-, (1Z)-
  • (Z)-1-(3-Ethyl-5-hydroxybenzo[d]thiazol-2(3H)-ylidene)propan-2-one
  • CID 69538603
  • INDY, DYRK1A/B inhibitor
  • INDY, 10 mM in DMSO
  • (1Z)-1-(3-ethyl-5-hydroxy-1,3-benzothiazol-2(3H)-ylidene)-2-propanone
  • 1169755-45-6