INDY
- Product Name
- INDY
- CAS No.
- 1169755-45-6
- Chemical Name
- INDY
- Synonyms
- INDY;(1Z)-1-(3-Ethyl-5-hydroxy-1,3-benzothiazol-2(3H)-ylidene)acetone;(1Z)-1-(3-Ethyl-5-hydroxy-2(3H)-benzothiazolylidene)-2-propanone;(1Z)-1-(3-ethyl-5-hydroxy-1,3-benzothiazol-2-ylidene)propan-2-one;(Z)-1-(3-Ethyl-5-hydroxybenzo[d]thiazol-2(3H)-ylidene)propan-2-one;2-Propanone, 1-(3-ethyl-5-hydroxy-2(3H)-benzothiazolylidene)-, (1Z)-
- CBNumber
- CB52748091
- Molecular Formula
- C12H13NO2S
- Formula Weight
- 235.3
- MOL File
- 1169755-45-6.mol
INDY Property
- Boiling point:
- 409.2±45.0 °C(Predicted)
- Density
- 1.337±0.06 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- DMSO: soluble5mg/mL, clear (warmed)
- pka
- 9.67±0.20(Predicted)
- form
- powder
- color
- white to beige
Safety
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- SML1011
- Product name
- INDY
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $103
- Updated
- 2024/03/01
- Product number
- SML1011
- Product name
- INDY
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $334
- Updated
- 2024/03/01
- Product number
- 23895
- Product name
- INDY
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $30
- Updated
- 2024/03/01
- Product number
- 23895
- Product name
- INDY
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $75
- Updated
- 2024/03/01
- Product number
- 23895
- Product name
- INDY
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $134
- Updated
- 2024/03/01
INDY Chemical Properties,Usage,Production
Description
INDY is an ATP-competitive inhibitor of dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A (DYRK1A; Ki = 180 nM; IC50 = 240 nM). It is selective for DYRK1A over monoamine oxidase (MAO) A and B at concentrations up to 100 μM. INDY inhibits DYRK1A phosphorylation of tau in COS-7 cells expressing EGFP-DYRK1A and EGFP-tau in a concentration-dependent manner. It also restores signaling through nuclear factory of activated T cells (NFAT) and NFAT-dependent transcription in HEK293 cells overexpressing DYRK1A. In vivo, INDY reverses developmental deformities induced by DYRK1A overexpression in X. laevis embryos. INDY also induces proliferation of human and rat β-cells and increases insulin secretion by human islets in vitro.
Uses
INDY is a dual-specificity tyrosine-(Y)-phosphorylation-regulated kinase 1A/B (DYRK1A/B) inhibitor (1,2).
storage
-20°C
INDY Preparation Products And Raw materials
Raw materials
Preparation Products
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