1,2,3,4-Tetrahydro-4-oxo-N-(phenylmethyl)-2-thioxo-3-[3-(trifluoromethyl)phenyl]-7-quinazolinecarboxamide

Product Name: 1,2,3,4-Tetrahydro-4-oxo-N-(phenylmethyl)-2-thioxo-3-[3-(trifluoromethyl)phenyl]-7-quinazolinecarboxamide
CAS No.: 403718-45-6
Chemical Name: 1,2,3,4-Tetrahydro-4-oxo-N-(phenylmethyl)-2-thioxo-3-[3-(trifluoromethyl)phenyl]-7-quinazolinecarboxamide
Synonyms: Qc1;Threonine Dehydrogenase Inhibitor, QC1;Threonine Dehydrogenase Inhibitor, QC1 - CAS 403718-45-6 - Calbiochem;N-Benzyl-4-oxo-2-thioxo-3-(3-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydroquinazoline-7-carboxamide;1,2,3,4-Tetrahydro-4-oxo-N-(phenylmethyl)-2-thioxo-3-[3-(trifluoromethyl)phenyl]-7-quinazolinecarboxamide;7-Quinazolinecarboxamide, 1,2,3,4-tetrahydro-4-oxo-N-(phenylmethyl)-2-thioxo-3-[3-(trifluoromethyl)phenyl]-
CBNumber: CB52750492
Molecular Formula: C23H16F3N3O2S
Formula Weight: 455.45
MOL File: 403718-45-6.mol

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1,2,3,4-Tetrahydro-4-oxo-N-(phenylmethyl)-2-thioxo-3-[3-(trifluoromethyl)phenyl]-7-quinazolinecarboxamide Property

Density: 1.48±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: soluble5mg/mL (clear solution, warmed)
pka: 10.13±0.20(Predicted)
form: White powder
color: white to beige

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0481
Product name: Qc1
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $130
Updated: 2024/03/01

Sigma-Aldrich

Product number: 603425
Product name: Threonine Dehydrogenase Inhibitor, QC1
Packaging: 10mg
Price: $223
Updated: 2023/01/07

Sigma-Aldrich

Product number: SML0481
Product name: Qc1
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $465
Updated: 2022/05/15

Tocris

Product number: 5055
Product name: Qc1
Purity: ≥98%(HPLC)
Packaging: 50
Price: $679
Updated: 2021/12/16

Tocris

Product number: 5055
Product name: Qc1
Purity: ≥98%(HPLC)
Packaging: 10
Price: $162
Updated: 2021/12/16

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1,2,3,4-Tetrahydro-4-oxo-N-(phenylmethyl)-2-thioxo-3-[3-(trifluoromethyl)phenyl]-7-quinazolinecarboxamide Chemical Properties,Usage,Production

Uses

Qc 1 is used in the preparation of bis(benzylcarbamoyl)methylthio dihydroquinazolinones.

Biological Activity

Qc1 is a reversible inhibitor of threonine dehydroxygenase (TDH). The IC50 value for inhibition of TDH by Qc1 is 500 nM, with no detectable inhibition of other dehydroxygenase enzymes at concentrations up to 10 mM. Qc1 induces arrest and autophagy of mouse ES cells with an EC50 of 3 mM.

1,2,3,4-Tetrahydro-4-oxo-N-(phenylmethyl)-2-thioxo-3-[3-(trifluoromethyl)phenyl]-7-quinazolinecarboxamide Preparation Products And Raw materials

Raw materials

Preparation Products

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1,2,3,4-Tetrahydro-4-oxo-N-(phenylmethyl)-2-thioxo-3-[3-(trifluoromethyl)phenyl]-7-quinazolinecarboxamide Suppliers

China 25 United Kingdom 1 United States 6 USA 1 Global 33

Tianjin Kailiqi Biotechnology Co., Ltd.

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403718-45-6, 1,2,3,4-Tetrahydro-4-oxo-N-(phenylmethyl)-2-thioxo-3-[3-(trifluoromethyl)phenyl]-7-quinazolinecarboxamideRelated Search:

1,2,3,4-Tetrahydro-4-oxo-N-(phenylmethyl)-2-thioxo-3-[3-(trifluoromethyl)phenyl]-7-quinazolinecarboxamide

Qc1

Threonine Dehydrogenase Inhibitor, QC1

Threonine Dehydrogenase Inhibitor, QC1 - CAS 403718-45-6 - Calbiochem

7-Quinazolinecarboxamide, 1,2,3,4-tetrahydro-4-oxo-N-(phenylmethyl)-2-thioxo-3-[3-(trifluoromethyl)phenyl]-

N-Benzyl-4-oxo-2-thioxo-3-(3-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydroquinazoline-7-carboxamide

403718-45-6