2-(3-Bromo-4-methoxyphenyl)-3-[(4-chlorophenyl)sulfonyl]-thiazolidine
- Product Name
- 2-(3-Bromo-4-methoxyphenyl)-3-[(4-chlorophenyl)sulfonyl]-thiazolidine
- CAS No.
- 313669-88-4
- Chemical Name
- 2-(3-Bromo-4-methoxyphenyl)-3-[(4-chlorophenyl)sulfonyl]-thiazolidine
- Synonyms
- BMS-986122;BMS-986122 ，E0472;BMS-986122 >=98% (HPLC);BMS-986122, 10 mM in DMSO;2-(3-Bromo-4-methoxyphenyl)-3-[(4-chlorophenyl)sulfonyl]-thiazolidine;Thiazolidine, 2-(3-bromo-4-methoxyphenyl)-3-[(4-chlorophenyl)sulfonyl]-;positive,BMS986122,modulator,allosteric,recruitment,β-arrestin,adenylyl,Opioid Receptor,BMS-986122,inhibit,cyclase,Inhibitor,protein
- CBNumber
- CB52750513
- Molecular Formula
- C16H15BrClNO3S2
- Formula Weight
- 448.78
- MOL File
- 313669-88-4.mol
2-(3-Bromo-4-methoxyphenyl)-3-[(4-chlorophenyl)sulfonyl]-thiazolidine Property
- Boiling point:
- 567.2±60.0 °C(Predicted)
- Density
- 1.586±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: soluble20mg/mL, clear
- form
- powder
- pka
- -8.81±0.40(Predicted)
- color
- white to beige
N-Bromosuccinimide Price
- Product number
- SML0917
- Product name
- BMS-986122
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $144
- Updated
- 2025/07/31
- Product number
- SML0917
- Product name
- BMS-986122
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $552
- Updated
- 2025/07/31
- Product number
- 23269
- Product name
- BMS 986122
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $49
- Updated
- 2024/03/01
- Product number
- 23269
- Product name
- BMS 986122
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $227
- Updated
- 2024/03/01
- Product number
- 0461CN
- Product name
- 2-(3-Bromo-4-methoxyphenyl)-3-(4-chlorophenyl)sulfonyl-1,3-thiazolidine
- Packaging
- 1mg
- Price
- $152
- Updated
- 2021/12/16
2-(3-Bromo-4-methoxyphenyl)-3-[(4-chlorophenyl)sulfonyl]-thiazolidine Chemical Properties,Usage,Production
Uses
BMS-986122 is a selective, potent positive allosteric modulator of the mu-opioid receptor (μ-OR). BMS-986122 shows potentiation of orthosteric agonist-mediated β-arrestin recruitment, adenylyl cyclase inhibition, and G protein activation. BMS-986122 potentiates DAMGO-mediated [35S]GTPγS binding in mouse brain membranes[1][2].
Biochem/physiol Actions
BMS-986122 may exhibit an antinociception effect in vivo by increasing the efficiency of Met-enkephalin (met-Enk) to inhibit γ aminobutyric acid (GABA) release in the periaqueductal gray region of the brain.
IC 50
μ Opioid Receptor/MOR
References
[1] Burford NT, et al. Discovery of positive allosteric modulators and silent allosteric modulators of the μ-opioid receptor. Proc Natl Acad Sci U S A. 2013;110(26):10830-10835. DOI:10.1073/pnas.1300393110
[2] Kandasamy R, et al. Positive allosteric modulation of the mu-opioid receptor produces analgesia with reduced side effects. Proc Natl Acad Sci U S A. 2021;118(16):e2000017118. DOI:10.1073/pnas.2000017118
[3] Livingston KE, Alt A, Canals M, Traynor JR. Pharmacologic Evidence for a Putative Conserved Allosteric Site on Opioid Receptors. Mol Pharmacol. 2018;93(2):157-167. DOI:10.1124/mol.117.109561
2-(3-Bromo-4-methoxyphenyl)-3-[(4-chlorophenyl)sulfonyl]-thiazolidine Preparation Products And Raw materials
Raw materials
Preparation Products
2-(3-Bromo-4-methoxyphenyl)-3-[(4-chlorophenyl)sulfonyl]-thiazolidine Suppliers
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