BC-1258

Product Name: BC-1258
CAS No.: 1507370-40-2
Chemical Name: BC-1258
Synonyms: BC-1258;N1,N2-Bis(4-(thiazol-2-yl)benzyl)ethane-1,2-diamine;N,N′-Bis-(4-thiazol-2-yl-benzyl)-ethane-1,2-diamine;1,2-Ethanediamine, N1,N2-bis[[4-(2-thiazolyl)phenyl]methyl]-;N,N'-bis[[4-(1,3-thiazol-2-yl)phenyl]methyl]ethane-1,2-diamine;LRR,F-box,inhibit,repeat,BC-?1258,BC ?1258,FBXL2,Apoptosis,tumor,Inhibitor,BC?1258;LRR|||F-box|||BC1258|||inhibit|||repeat|||BC-1258|||BC-1258|||BC-?1258|||BC ?1258|||FBXL2|||Apoptosis|||BC-1258|||tumor|||Inhibitor|||BC?1258|||BC 1258
CBNumber: CB52750609
Molecular Formula: C22H22N4S2
Formula Weight: 406.57
MOL File: 1507370-40-2.mol

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BC-1258 Property

storage temp.: 2-8°C
solubility: DMSO: soluble10mg/mL, clear (warmed)
form: powder
color: white to beige
InChI: InChI=1S/C22H22N4S2/c1-5-19(21-25-11-13-27-21)6-2-17(1)15-23-9-10-24-16-18-3-7-20(8-4-18)22-26-12-14-28-22/h1-8,11-14,23-24H,9-10,15-16H2
InChIKey: FRTSLZJCGAFSET-UHFFFAOYSA-N
SMILES: C(NCC1=CC=C(C2=NC=CS2)C=C1)CNCC1=CC=C(C2=NC=CS2)C=C1

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1021
Product name: BC-1258
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $105
Updated: 2022/05/15

Sigma-Aldrich

Product number: SML1021
Product name: BC-1258
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $423
Updated: 2022/05/15

AK Scientific

Product number: SYN5045
Product name: BC-1258
Packaging: 100mg
Price: $830
Updated: 2021/12/16

DC Chemicals

Product number: DC43054
Product name: BC-1258
Purity: >98%
Packaging: 1g
Price: $1600
Updated: 2021/12/16

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BC-1258 Chemical Properties,Usage,Production

Description

BC-1258 (N,N′-Bis-(4-thiazol-2-yl-benzyl)-ethane-1,2-diamine) is a potent activator of unique E3 ligase F-box/LRR-repeat protein 2 (FBXL2) that increases levels of FBXLs protein, thus promoting Aurora B degradation. BC-1258 induces mitotic arrest and apoptosis of tumorigenic cells. Also BC-1258 inhibits tumor formation in athymic nude mice.

Mechanism of action

BC-1258 is a unique small molecule F-box/LRR-repeat protein 2 (FBXL2) activator that stabilized and increased levels of FBXL2 protein that promoted Aurora B degradation, resulting in tetraploidy, mitotic arrest and apoptosis of tumorigenic cells, and profoundly inhibiting tumor formation in athymic nude mice. It is sufficient to stabilize and upregulate FBXL2 levels, and, when administered in vivo, prematurely depletes Aurora B by SCFFBXL2-induced ubiquitination and degradation, leading to cell death and inhibiting growth of human leukemic cells in a xenograft model[1].

References

[1] B B Chen. “Skp-cullin-F box E3 ligase component FBXL2 ubiquitinates Aurora B to inhibit tumorigenesis.” Cell Death & Disease (2013): e759.

BC-1258 Preparation Products And Raw materials

Raw materials

Preparation Products

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BC-1258 Suppliers

China 26 United Kingdom 1 United States 3 Global 30

Pharmacodia (Beijing) Co.,Ltd

Tel: +86-400-851-9921
Fax: +86-10-82826195
Email: sales@pharmacodia.com
Country: China
ProdList: 2317
Advantage: 55

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9806
Advantage: 58

Tianjin Kailiqi Biotechnology Co., Ltd.

Tel: 15076683720
Fax: 022-23754520
Email: klq@cw-bio.com
Country: China
ProdList: 5930
Advantage: 55

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Lynnchem

Tel: 86-(0)29-85992781 17792393971
Email: info@lynnchem.com
Country: China
ProdList: 4587
Advantage: 58

Novachemistry

Tel: 44-20819178-90 02081917890
Fax: (0)2080432064
Email: info@novachemistry.com
Country: United Kingdom
ProdList: 4381
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32161
Advantage: 58

DC Chemicals

Tel: 021-58447131 13564518121
Email: sales@dcchemicals.com
Country: China
ProdList: 9409
Advantage: 58

Changzhou Chenhong Biotechnology Co., Ltd.

Tel: 0519-85788828 13775037613
Email: sales@chemrenpharm.com
Country: China
ProdList: 3600
Advantage: 58

Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd

Tel: 15317229551
Fax: QQ:3607245178
Email: 15151849396@163.com
Country: China
ProdList: 999
Advantage: 58

1507370-40-2, BC-1258Related Search:

N,N′-Bis-(4-thiazol-2-yl-benzyl)-ethane-1,2-diamine

BC-1258

N,N'-bis[[4-(1,3-thiazol-2-yl)phenyl]methyl]ethane-1,2-diamine

1,2-Ethanediamine, N1,N2-bis[[4-(2-thiazolyl)phenyl]methyl]-

LRR,F-box,inhibit,repeat,BC-?1258,BC ?1258,FBXL2,Apoptosis,tumor,Inhibitor,BC?1258

N1,N2-Bis(4-(thiazol-2-yl)benzyl)ethane-1,2-diamine

LRR|||F-box|||BC1258|||inhibit|||repeat|||BC-1258|||BC-1258|||BC-?1258|||BC ?1258|||FBXL2|||Apoptosis|||BC-1258|||tumor|||Inhibitor|||BC?1258|||BC 1258

1507370-40-2