BC-1258
- Product Name
- BC-1258
- CAS No.
- 1507370-40-2
- Chemical Name
- BC-1258
- Synonyms
- BC-1258;N1,N2-Bis(4-(thiazol-2-yl)benzyl)ethane-1,2-diamine;N,N′-Bis-(4-thiazol-2-yl-benzyl)-ethane-1,2-diamine;1,2-Ethanediamine, N1,N2-bis[[4-(2-thiazolyl)phenyl]methyl]-;N,N'-bis[[4-(1,3-thiazol-2-yl)phenyl]methyl]ethane-1,2-diamine;LRR,F-box,inhibit,repeat,BC-?1258,BC ?1258,FBXL2,Apoptosis,tumor,Inhibitor,BC?1258;LRR|||F-box|||BC1258|||inhibit|||repeat|||BC-1258|||BC-1258|||BC-?1258|||BC ?1258|||FBXL2|||Apoptosis|||BC-1258|||tumor|||Inhibitor|||BC?1258|||BC 1258
- CBNumber
- CB52750609
- Molecular Formula
- C22H22N4S2
- Formula Weight
- 406.57
- MOL File
- 1507370-40-2.mol
BC-1258 Property
- storage temp.
- 2-8°C
- solubility
- DMSO: soluble10mg/mL, clear (warmed)
- form
- powder
- color
- white to beige
- InChI
- InChI=1S/C22H22N4S2/c1-5-19(21-25-11-13-27-21)6-2-17(1)15-23-9-10-24-16-18-3-7-20(8-4-18)22-26-12-14-28-22/h1-8,11-14,23-24H,9-10,15-16H2
- InChIKey
- FRTSLZJCGAFSET-UHFFFAOYSA-N
- SMILES
- C(NCC1=CC=C(C2=NC=CS2)C=C1)CNCC1=CC=C(C2=NC=CS2)C=C1
Safety
- WGK Germany
- 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330Rinse mouth.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- SML1021
- Product name
- BC-1258
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $105
- Updated
- 2022/05/15
- Product number
- SML1021
- Product name
- BC-1258
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $423
- Updated
- 2022/05/15
- Product number
- SYN5045
- Product name
- BC-1258
- Packaging
- 100mg
- Price
- $830
- Updated
- 2021/12/16
- Product number
- DC43054
- Product name
- BC-1258
- Purity
- >98%
- Packaging
- 1g
- Price
- $1600
- Updated
- 2021/12/16
BC-1258 Chemical Properties,Usage,Production
Description
BC-1258 (N,N′-Bis-(4-thiazol-2-yl-benzyl)-ethane-1,2-diamine) is a potent activator of unique E3 ligase F-box/LRR-repeat protein 2 (FBXL2) that increases levels of FBXLs protein, thus promoting Aurora B degradation. BC-1258 induces mitotic arrest and apoptosis of tumorigenic cells. Also BC-1258 inhibits tumor formation in athymic nude mice.
Mechanism of action
BC-1258 is a unique small molecule F-box/LRR-repeat protein 2 (FBXL2) activator that stabilized and increased levels of FBXL2 protein that promoted Aurora B degradation, resulting in tetraploidy, mitotic arrest and apoptosis of tumorigenic cells, and profoundly inhibiting tumor formation in athymic nude mice. It is sufficient to stabilize and upregulate FBXL2 levels, and, when administered in vivo, prematurely depletes Aurora B by SCFFBXL2-induced ubiquitination and degradation, leading to cell death and inhibiting growth of human leukemic cells in a xenograft model[1].
References
[1] B B Chen. “Skp-cullin-F box E3 ligase component FBXL2 ubiquitinates Aurora B to inhibit tumorigenesis.” Cell Death & Disease (2013): e759.
BC-1258 Preparation Products And Raw materials
Raw materials
Preparation Products
BC-1258 Suppliers
- Tel
- +1-781-999-5354 +1-00000000000
- marketing@targetmol.com
- Country
- United States
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