N-(1,4-Dihydro-1,4-dioxo-2-naphthalenyl)-L-tryptophan
- Product Name
- N-(1,4-Dihydro-1,4-dioxo-2-naphthalenyl)-L-tryptophan
- CAS No.
- 185351-19-3
- Chemical Name
- N-(1,4-Dihydro-1,4-dioxo-2-naphthalenyl)-L-tryptophan
- Synonyms
- NQTrp;NQTrp >=98% (HPLC);1,4-Naphthoquinon-2-yl-l-tryptophan;N-(1,4-Dihydro-1,4-dioxo-2-naphthalenyl)-L-tryptophan;L-Tryptophan, N-(1,4-dihydro-1,4-dioxo-2-naphthalenyl)-;(S)-2-((1,4-Dioxo-1,4-dihydronaphthalen-2-yl)amino)-3-(1H-indol-3-yl)propanoic acid;(2S)-2-[(1,4-dioxo-1,4-dihydronaphthalen-2-yl)amino]-3-(1H-indol-3-yl)propanoic acid
- CBNumber
- CB52751095
- Molecular Formula
- C21H16N2O4
- Formula Weight
- 360.36
- MOL File
- 185351-19-3.mol
N-(1,4-Dihydro-1,4-dioxo-2-naphthalenyl)-L-tryptophan Property
- Melting point:
- 208.0-211.0 °C
- Boiling point:
- 658.9±55.0 °C(Predicted)
- Density
- 1.45±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: soluble20mg/mL, clear
- form
- powder
- pka
- 3.89±0.10(Predicted)
- color
- orange to dark orange-red
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330Rinse mouth.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- SML1104
- Product name
- NQTrp
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $118
- Updated
- 2024/03/01
- Product number
- SML1104
- Product name
- NQTrp
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $476
- Updated
- 2024/03/01
- Product number
- 19127
- Product name
- NQTrp
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $25
- Updated
- 2024/03/01
- Product number
- 19127
- Product name
- NQTrp
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $94
- Updated
- 2024/03/01
- Product number
- 19127
- Product name
- NQTrp
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $140
- Updated
- 2024/03/01
N-(1,4-Dihydro-1,4-dioxo-2-naphthalenyl)-L-tryptophan Chemical Properties,Usage,Production
Description
NQTrp is an inhibitor of Alzheimer’s disease-associated amyloid β (Aβ) oligomerization and fibrillization (IC50 = 50 nM for formation of fibrils from Aβ1-42). It has been shown to reduce the cytotoxic effect of Aβ oligomers in a cultured neuronal cell line.
Uses
NQTrp is a inhibitor of Aβ1-42 aggregation, altering Aβ self-assembly and reducing toxicity.
References
[1]. scherzer-attali r, pellarin r, convertino m, et al. complete phenotypic recovery of an alzheimer's disease model by a quinone-tryptophan hybrid aggregation inhibitor. plos one. 2010 jun 14;5(6):e11101.
[2]. zhang t, xu w, mu y, et al. atomic and dynamic insights into the beneficial effect of the 1,4-naphthoquinon-2-yl-l-tryptophan inhibitor on alzheimer's aβ1-42 dimer in terms of aggregation and toxicity. acs chem neurosci. 2014 feb 19;5(2):148-59.
N-(1,4-Dihydro-1,4-dioxo-2-naphthalenyl)-L-tryptophan Preparation Products And Raw materials
Raw materials
Preparation Products
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