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Isoprenaline hydrochloride

Product Name
Isoprenaline hydrochloride
CAS No.
51-30-9
Chemical Name
Isoprenaline hydrochloride
Synonyms
ISOPRENALINE HCL;ISOPROTERENOL HYDROCHLORIDE;isuprel;Isovon;Isomenyl;Mistarel;euspiran;isadrine;Proterno;proternol
CBNumber
CB5276844
Molecular Formula
C11H18ClNO3
Formula Weight
247.72
MOL File
51-30-9.mol
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Isoprenaline hydrochloride Property

Melting point:
165-175 °C (dec.)(lit.)
Boiling point:
192°C (rough estimate)
Density 
1.2296 (rough estimate)
refractive index 
1.6000 (estimate)
storage temp. 
2-8°C
solubility 
Freely soluble in water, sparingly soluble in ethanol (96 per cent), practically insoluble in methylene chloride.
form 
White solid
color 
White to Off-White
Water Solubility 
Soluble
BRN 
3917363
Stability:
Stable, but may be air and light sensitive. Incompatible with strong oxidizing agents.
InChI
InChI=1S/C11H17NO3.ClH/c1-7(2)12-6-11(15)8-3-4-9(13)10(14)5-8;/h3-5,7,11-15H,6H2,1-2H3;1H
InChIKey
IROWCYIEJAOFOW-UHFFFAOYSA-N
SMILES
C1(=CC=C(O)C(O)=C1)C(O)CNC(C)C.Cl
CAS DataBase Reference
51-30-9(CAS DataBase Reference)
EPA Substance Registry System
Isoproterenol hydrochloride (51-30-9)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
2
RTECS 
DO1925000
F 
3-8-10
HS Code 
29225090
Toxicity
LD50 oral in rabbit: 3070mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H303May be harmfulif swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHR2722
Product name
Isoproterenol Hydrochloride
Purity
Pharmaceutical Secondary Standard; Certified Reference Material
Packaging
250MG
Price
$200
Updated
2024/03/01
Sigma-Aldrich
Product number
BP205
Product name
Isoprenaline hydrochloride
Purity
British Pharmacopoeia (BP) Reference Standard
Packaging
100MG
Price
$257
Updated
2024/03/01
Sigma-Aldrich
Product number
420355
Product name
Isoproterenol, Hydrochloride
Purity
Phenethylamine derivative.
Packaging
100mg
Price
$54.7
Updated
2024/03/01
Sigma-Aldrich
Product number
1351005
Product name
Isoproterenol hydrochloride
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
125mg
Price
$358
Updated
2024/03/01
TCI Chemical
Product number
I0260
Product name
Isoproterenol Hydrochloride
Purity
>99.0%(T)
Packaging
5g
Price
$74
Updated
2024/03/01
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Isoprenaline hydrochloride Chemical Properties,Usage,Production

Description

Isoprenaline hydrochloride is an FDA-approved injectable drug that is the hydrochloride form of isoprenaline and is used as a bronchodilator, adrenergic beta agonist, cardiotonic, and sympathomimetic. Selective beta-adrenergic agonist that increases cytoplasmic cAMP. promotes glycogenolysis and causes bronchodilation. Increases Cl- diffusion and potential difference in rabbit tracheal cells via nitric oxide production. In addition, it can be used as an inducer in an experimental rat model of induced myocardial infarction[1].

Chemical Properties

White or almost white, crystalline powder.

Uses

Isoproterenol is a non-selective beta-adrenergic agonist. Isoproterenol is used in the treatment of bradycardia; bronchodilator.

Uses

Isoproterenol hydrochloride is used as a selective β-adrenergic agonist, increases cytosolic cAMP.

Definition

ChEBI: DL-Isoprenaline hydrochloride is a member of catechols.

brand name

Isuprel (Hospira); Isuprel (Sanofi Aventis); Vapo- ISO (Fisons).

General Description

Odorless white crystalline powder. Slightly bitter taste. Aqueous solutions turn brownish-pink upon prolonged exposure to air.

Air & Water Reactions

May be sensitive to exposure to air and light. . Water soluble.

Reactivity Profile

An acid organic salt. Materials in this group are generally soluble in water. The resulting solutions contain moderate concentrations of hydrogen ions and have pH's of less than 7.0. They react as acids to neutralize bases. These neutralizations generate heat, but less or far less than is generated by neutralization of inorganic acids, inorganic oxoacids, and carboxylic acid. They usually do not react as either oxidizing agents or reducing agents but such behavior is not impossible.

Health Hazard

SYMPTOMS: Symptoms of exposure to Isoprenaline hydrochloride may include tremors, nervous apprehension, palpitations of the heart, epigastric distress, cardiac arrhythmias, myocardial necrosis, cardiac arrest, tachycardia, headache, flushing of the skin, anginal pain, nausea, dizziness, weakness, and sweating.

Fire Hazard

Flash point data for Isoprenaline hydrochloride are not available. Isoprenaline hydrochloride is probably combustible.

Biological Activity

Standard selective β -adrenoceptor agonist; vasorelaxant and bronchodilator. Activation of β 2 receptors activates downstream PKA and ERK, and may stimulate NO-mediated endothelium-dependent smooth muscle relaxation. Active in vivo . Also available as part of the β -Adrenoceptor Agonist Tocriset™ and Mixed Adrenergic Tocriset™ .

Biochem/physiol Actions

β-adrenoceptor agonist; increases cytosolic cAMP.

storage

Store at RT

References

[1] FANG WANG. Fucoxanthin averts isoprenaline hydrochloride-induced myocardial infarction in rats[J]. Pharmacognosy Magazine, 2020, 16 1: 214-220. DOI:10.4103/pm.pm\_357\_19.

Isoprenaline hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Isoprenaline hydrochloride manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Isoprenaline hydrochloride 51-30-9
Price
US $0.00/Kg/Bag
Min. Order
1KG
Purity
97.0%~101.5%; USP40
Supply Ability
800kg/month
Release date
2021-06-03
airuikechemical co., ltd.
Product
Isoprenaline hydrochloride 51-30-9
Price
US $0.00-0.00/g
Min. Order
1g
Purity
99.9%
Supply Ability
20 tons
Release date
2024-04-03
shandong perfect biotechnology co.ltd
Product
Isoprenaline Hydrochloride 51-30-9
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99% HPLC
Supply Ability
5 TON
Release date
2023-07-07

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