1-BROMO-4-(1,3-DIOXOLAN-2-YL)-3-FLUOROBENZENE

Product Name: 1-BROMO-4-(1,3-DIOXOLAN-2-YL)-3-FLUOROBENZENE
CAS No.: 248270-23-7
Chemical Name: 1-BROMO-4-(1,3-DIOXOLAN-2-YL)-3-FLUOROBENZENE
Synonyms: RARECHEM AL BP 0386;2-(4-bromo-2-fluorophenyl)-1,3-dioxolane;1,3-Dioxolane, 2-(4-bromo-2-fluorophenyl)-;1-BROMO-4-(1,3-DIOXOLAN-2-YL)-3-FLUOROBENZENE
CBNumber: CB5277609
Molecular Formula: C9H8BrFO2
Formula Weight: 247.06
MOL File: 248270-23-7.mol

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1-BROMO-4-(1,3-DIOXOLAN-2-YL)-3-FLUOROBENZENE Property

Boiling point:: 261.7±40.0 °C(Predicted)
Density: 1.590±0.06 g/cm3(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B700320
Product name: 2-(4-Bromo-2-fluorophenyl)-1,3-dioxolane
Packaging: 50mg
Price: $45
Updated: 2021/12/16

Matrix Scientific

Product number: 087146
Product name: 1-Bromo-4-(1,3-dioxolan-2-yl)-3-fluorobenzene
Purity: 97%
Packaging: 1g
Price: $169
Updated: 2021/12/16

AK Scientific

Product number: 8337AD
Product name: 1-Bromo-4-(1,3-dioxolan-2-yl)-3-fluorobenzene
Packaging: 1g
Price: $188
Updated: 2021/12/16

Matrix Scientific

Product number: 087146
Product name: 1-Bromo-4-(1,3-dioxolan-2-yl)-3-fluorobenzene
Purity: 97%
Packaging: 2g
Price: $260
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0029472
Product name: 1-BROMO-4-(1,3-DIOXOLAN-2-YL)-3-FLUOROBENZENE
Purity: 95.00%
Packaging: 1G
Price: $301.35
Updated: 2021/12/16

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1-BROMO-4-(1,3-DIOXOLAN-2-YL)-3-FLUOROBENZENE Chemical Properties,Usage,Production

Synthesis

107-21-1

57848-46-1

248270-23-7

The general procedure for the synthesis of 2-(2-fluoro-4-bromophenyl)-1,3-dioxolane from ethylene glycol and 4-bromo-2-fluorobenzaldehyde was as follows: 4-bromo-2-fluorobenzaldehyde (9.4 g, 46.3 mmol), ethylene glycol (13.2 mL), triethyl orthoformate (6.6 mL), and p-toluene sulfonate (0.09 g, 0.473 mmol) were reacted in aqueous solution in 1,2- Dichloroethane (50 mL) in a stirred reaction at 80 °C for 2.5 hours. After completion of the reaction, it was cooled to room temperature, and the reaction mixture was washed sequentially with saturated sodium bicarbonate solution, water and brine, dried with anhydrous magnesium sulfate, and subsequently concentrated under reduced pressure to afford 11.4 g of the target product (light yellow oil, 100% yield). The 1H NMR (CDCl3) data of the product were as follows: δ 7.41 (t, J = 8.1 Hz, 1H), 7.30 (dd, J = 8.1, 1.8 Hz, 1H), 7.25 (dd, J = 9.6, 1.8 Hz, 1H), 6.02 (s, 1H), 4.13 (m, 2H), 4.04 (m, 2H).

References

[1] Patent: WO2006/115835, 2006, A2. Location in patent: Page/Page column 47
[2] Patent: WO2005/12220, 2005, A2. Location in patent: Page/Page column 83
[3] Patent: US2004/106653, 2004, A1. Location in patent: Page/Page column 43
[4] Patent: WO2004/45610, 2004, A1. Location in patent: Page/Page column 142
[5] Patent: WO2006/115845, 2006, A1. Location in patent: Page/Page column 83

1-BROMO-4-(1,3-DIOXOLAN-2-YL)-3-FLUOROBENZENE Preparation Products And Raw materials

Raw materials

Preparation Products

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1-BROMO-4-(1,3-DIOXOLAN-2-YL)-3-FLUOROBENZENE Suppliers

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248270-23-7, 1-BROMO-4-(1,3-DIOXOLAN-2-YL)-3-FLUOROBENZENERelated Search:

RARECHEM AL BP 1306 RARECHEM AL BP 1302 4-BROMOBENZALDEHYDE DIMETHYL ACETAL RARECHEM AL BP 1308 2-(4-BROMOPHENYL)-1,3-DIOXOLANE 1-BROMO-4-(1,3-DIOXOLAN-2-YL)-3-FLUOROBENZENE

2-(4-bromo-2-fluorophenyl)-1,3-dioxolane

RARECHEM AL BP 0386

1-BROMO-4-(1,3-DIOXOLAN-2-YL)-3-FLUOROBENZENE

1,3-Dioxolane, 2-(4-bromo-2-fluorophenyl)-

248270-23-7