1-BROMO-4-(1,3-DIOXOLAN-2-YL)-3-FLUOROBENZENE
- Product Name
- 1-BROMO-4-(1,3-DIOXOLAN-2-YL)-3-FLUOROBENZENE
- CAS No.
- 248270-23-7
- Chemical Name
- 1-BROMO-4-(1,3-DIOXOLAN-2-YL)-3-FLUOROBENZENE
- Synonyms
- RARECHEM AL BP 0386;2-(4-bromo-2-fluorophenyl)-1,3-dioxolane;1,3-Dioxolane, 2-(4-bromo-2-fluorophenyl)-;1-BROMO-4-(1,3-DIOXOLAN-2-YL)-3-FLUOROBENZENE
- CBNumber
- CB5277609
- Molecular Formula
- C9H8BrFO2
- Formula Weight
- 247.06
- MOL File
- 248270-23-7.mol
1-BROMO-4-(1,3-DIOXOLAN-2-YL)-3-FLUOROBENZENE Property
- Boiling point:
- 261.7±40.0 °C(Predicted)
- Density
- 1.590±0.06 g/cm3(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B700320
- Product name
- 2-(4-Bromo-2-fluorophenyl)-1,3-dioxolane
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 087146
- Product name
- 1-Bromo-4-(1,3-dioxolan-2-yl)-3-fluorobenzene
- Purity
- 97%
- Packaging
- 1g
- Price
- $169
- Updated
- 2021/12/16
- Product number
- 8337AD
- Product name
- 1-Bromo-4-(1,3-dioxolan-2-yl)-3-fluorobenzene
- Packaging
- 1g
- Price
- $188
- Updated
- 2021/12/16
- Product number
- 087146
- Product name
- 1-Bromo-4-(1,3-dioxolan-2-yl)-3-fluorobenzene
- Purity
- 97%
- Packaging
- 2g
- Price
- $260
- Updated
- 2021/12/16
- Product number
- 8337AD
- Product name
- 1-Bromo-4-(1,3-dioxolan-2-yl)-3-fluorobenzene
- Packaging
- 5g
- Price
- $458
- Updated
- 2021/12/16
1-BROMO-4-(1,3-DIOXOLAN-2-YL)-3-FLUOROBENZENE Chemical Properties,Usage,Production
Synthesis
107-21-1
57848-46-1
248270-23-7
The general procedure for the synthesis of 2-(2-fluoro-4-bromophenyl)-1,3-dioxolane from ethylene glycol and 4-bromo-2-fluorobenzaldehyde was as follows: 4-bromo-2-fluorobenzaldehyde (9.4 g, 46.3 mmol), ethylene glycol (13.2 mL), triethyl orthoformate (6.6 mL), and p-toluene sulfonate (0.09 g, 0.473 mmol) were reacted in aqueous solution in 1,2- Dichloroethane (50 mL) in a stirred reaction at 80 °C for 2.5 hours. After completion of the reaction, it was cooled to room temperature, and the reaction mixture was washed sequentially with saturated sodium bicarbonate solution, water and brine, dried with anhydrous magnesium sulfate, and subsequently concentrated under reduced pressure to afford 11.4 g of the target product (light yellow oil, 100% yield). The 1H NMR (CDCl3) data of the product were as follows: δ 7.41 (t, J = 8.1 Hz, 1H), 7.30 (dd, J = 8.1, 1.8 Hz, 1H), 7.25 (dd, J = 9.6, 1.8 Hz, 1H), 6.02 (s, 1H), 4.13 (m, 2H), 4.04 (m, 2H).
References
[1] Patent: WO2006/115835, 2006, A2. Location in patent: Page/Page column 47
[2] Patent: WO2005/12220, 2005, A2. Location in patent: Page/Page column 83
[3] Patent: US2004/106653, 2004, A1. Location in patent: Page/Page column 43
[4] Patent: WO2004/45610, 2004, A1. Location in patent: Page/Page column 142
[5] Patent: WO2006/115845, 2006, A1. Location in patent: Page/Page column 83
1-BROMO-4-(1,3-DIOXOLAN-2-YL)-3-FLUOROBENZENE Preparation Products And Raw materials
Raw materials
Preparation Products
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