Cefonicid

Product Name
Cefonicid
CAS No.
61270-58-4
Chemical Name
Cefonicid
Synonyms
Monocid;Cefodie;Pratled;Monocidur;CEFONICID;SKF-75073;7-beta(r*)))-;Cefonicid USP/EP/BP;amino)-8-oxo-3-(((1-sulfomethyl)-1h-tetrazol-5-yl)thio)methyl)-,(6r-(6-alpha,;(6R,7R)-7α-[[(R)-Hydroxyphenylacetyl]amino]-8-oxo-3-[[[1-(sulfomethyl)-1H-tetrazol-5-yl]thio]methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
CBNumber
CB5283109
Molecular Formula
C18H18N6O8S3
Formula Weight
542.57
MOL File
61270-58-4.mol
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Cefonicid Property

Density 
1.92±0.1 g/cm3(Predicted)
pka
-1.23±0.50(Predicted)
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Hazard and Precautionary Statements (GHS)

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Cefonicid Chemical Properties,Usage,Production

Description

Cefonicid has an unesterified D-mandelic acid moiety at C-7 and a methylsulfothiotetrazole group at C-3. The latter is related to the MTT moiety mentioned above under cefamandole nafate; however, the clotting problems and Antabuse-like side effects associated with MTT have not been reported with cefonicid. The extra acid group in the C-3 side chain leads to this molecule being sold as an injectable disodium salt. Pain and discomfort at IM sites is experienced by some patients, as is a burning sensation and phlebitis. Cefonicid has a longer half-life than the other members of its group but achieves this at the price of somewhat lower potency against Gram-positive bacteria and aerobes. The drug is somewhat unstable, needs to be protected from light and heat, and may yellow or darken. If modest, however, this does not necessarily mean that the potency has decreased significantly, but overt precipitation does. Kirby-Bauer disk testing may overestimate the sensitivity of β-lactamase–producing bacteria to this agent, so some extra caution in interpretation of laboratory results is required.

Uses

A semi-synthetic cephalosporin antibiotic related to Cefamandole. Antibacterial

Definition

ChEBI: A cephalosporin bearing {[1-(sulfomethyl)-1H-tetrazol-5-yl]sulfanyl}methyl and (R)-2-hydroxy-2-phenylacetamido groups at positions 3 and 7, respectively, of the cephem skeleton.

Antimicrobial activity

Activity against Gram-positive and Gram-negative organisms in vitro is depressed by the presence of 50% serum. It is highly bound to plasma protein (98%) and has an extended plasma half-life of 4.5–5 h. A 1 g intramuscular dose achieves a mean peak plasma concentration of around 83 mg/L. Following a 1 g intravenous bolus dose, mean peak plasma concentrations of 130–300 mg/L have been reported. In patients treated for community-acquired pneumonia, concentrations of 2–4 mg/L have been found in sputum.
It is predominantly excreted by renal secretion, 83–89% being recovered unchanged in the urine over 24 h. Plasma half-life is linearly related to creatinine clearance. As a result of its high protein binding it is not removed by hemodialysis.
It is generally well tolerated; pain on injection, rash and positive Coombs’ test are reported in some patients. It has been used to treat respiratory, soft tissue and urinary infections. Available in Italy.

Chemical Synthesis

Cefonicid, 7-D-mandelamido-3-[[(1-sulfomethyl]-1H-tetrazol-5-yl]thio] methyl]- 8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-2-carboxylic acid (32.1.2.26), is structurally similar to cefamandole and differs in the presence of a sulfonic acid group in the methyl substituent of the tetrazol ring. It is synthesized by a method analogous to that of the synthesis of cefamandole.

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Cefonicid Suppliers

BOC Sciences
Tel
Email
info@bocsci.com
Country
United States
ProdList
9942
Advantage
65
Beijing HuaMeiHuLiBiological Chemical
Tel
010-56205725;010-86181995
Fax
010-65763397
Email
waley188@sohu.com
Country
China
ProdList
12341
Advantage
58
Cheng Du Micxy Chemical Co.,Ltd
Tel
028-85632863-
Fax
028-85632863
Email
sales@micxy.com;
Country
China
ProdList
13065
Advantage
58
Nanjing Sunlida Biological Technology Co., Ltd.
Tel
025-57798810- ;025-57798810-
Fax
025-57019371
Email
sales@sunlidabio.com;sales@sunlidabio.com
Country
China
ProdList
3756
Advantage
55
Shanghai Kewel Chemical Co., Ltd.
Tel
021-64609169-
Fax
021-64609160
Email
kewelchemexp@yahoo.com
Country
China
ProdList
9839
Advantage
50
Hangzhou J&H Chemical Co., Ltd.
Tel
0571-87396432-
Fax
0571-87396431
Email
sales@jhechem.com;
Country
China
ProdList
13964
Advantage
53
West Asia Chemical Technology (Shandong) Co. Ltd
Fax
0539-6365991
Email
3007715519@qq.com;3007715519@qq.com
Country
China
ProdList
27467
Advantage
60
Raw material medicin reagent co.,Ltd
Tel
025-57798860
Email
sales@njromanme.com
Country
China
ProdList
4542
Advantage
58
Amadis Chemical Company Limited
Tel
0086-571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
132148
Advantage
58
Shandong Ono Chemical Co., Ltd.
Tel
0539-6362799(To 20)
Fax
0539-6362799(To 20)
Email
861669111@qq.com
Country
China
ProdList
10001
Advantage
58
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View Lastest Price from Cefonicid manufacturers

Dideu Industries Group Limited
Product
Cefonicid USP/EP/BP 61270-58-4
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons Min
Release date
2021-06-30
Shaanxi Dideu Medichem Co. Ltd
Product
Cefonicid 61270-58-4
Price
US $0.00-0.00/Kg
Min. Order
1KG
Purity
99.0%
Supply Ability
500 MT
Release date
2020-05-25
BOC Sciences
Product
Cefonicid 61270-58-4
Price
US $0.00/g
Min. Order
1g
Purity
98%
Supply Ability
1kg
Release date
2020-05-15

61270-58-4, CefonicidRelated Search:


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