Sodium cefamandole

Product Name: Sodium cefamandole
CAS No.: 30034-03-8
Chemical Name: Sodium cefamandole
Synonyms: sodium cefamandole;CEFAMANDOLE SODIUM;Cephamandole sodium;CEFAMANDOLE SODIUM SALT;Cefamandole Sodium (250 mg);Sodium cefamandole USP/EP/BP;monosodiumsalt,d-hyl-1h-tetrazol-5-yl)thio)methyl)-8-oxo;5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylicacid,7-mandelamido-3-(((1-met;Sodium 7-D-mandelamido-3-(1-methyl-1H-tetrazol-5-ylthiomethyl)-3-cephem-4-carboxylate;5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-mandelamido-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-, monosodium salt, D- (8CI)
CBNumber: CB3744569
Molecular Formula: C18H17N6NaO5S2
Formula Weight: 484.48
MOL File: 30034-03-8.mol

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Sodium cefamandole Property

Melting point:: >175°C (dec.)
storage temp.: Store at RT.
solubility: DMSO (Slightly), Methanol (Slightly), Water (Slightly)
form: Solid
color: White to Pale Yellow
Stability:: Moisture Sensitive
CAS DataBase Reference: 30034-03-8(CAS DataBase Reference)

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Safety

Hazard Codes: Xn
Risk Statements: 36/37/38-42/43
Safety Statements: 26-36
WGK Germany: 2
RTECS: XI0389000
Toxicity: mouse,LD50,intravenous,4460mg/kg (4460mg/kg),Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 26, Pg. 115, 1984.

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H315Causes skin irritation

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P272Contaminated work clothing should not be allowed out of the workplace.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P285In case of inadequate ventilation wear respiratory protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P341IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

P342+P311IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.

P362Take off contaminated clothing and wash before reuse.

P363Wash contaminated clothing before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 18138
Product name: Cefamandole (sodium salt)
Purity: ≥95%
Packaging: 25mg
Price: $49
Updated: 2024/03/01

Cayman Chemical

Product number: 18138
Product name: Cefamandole (sodium salt)
Purity: ≥95%
Packaging: 50mg
Price: $92
Updated: 2024/03/01

Cayman Chemical

Product number: 18138
Product name: Cefamandole (sodium salt)
Purity: ≥95%
Packaging: 100mg
Price: $172
Updated: 2024/03/01

Cayman Chemical

Product number: 18138
Product name: Cefamandole (sodium salt)
Purity: ≥95%
Packaging: 500mg
Price: $475
Updated: 2024/03/01

TRC

Product number: C237500
Product name: CefamandoleSodiumSalt
Packaging: 1g
Price: $605
Updated: 2021/12/16

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Sodium cefamandole Chemical Properties,Usage,Production

Description

Cefamandole is a cephalosporin antibiotic that is effective against E. coli (MIC values range from 0.25-2 mg/L depending on strain) as well as H. influenza, S. pneumoniae, and S. aureus. It has been used to study the expression and inhibition of penicillin-binding proteins on bacterial cell walls and to study antibiotic resistance.

Chemical Properties

White Solid

Uses

Antibacterial;Bacterial transpeptidase inhibitor

Uses

Broad-spectrum semi-synthetic cephalosporin antibiotic.

Definition

ChEBI: An organic sodium salt that is the sodium salt of cefamandole.

in vitro

the in-vitro effect of cefamandole was tested against 645 strains of bacteria isolated from clinical sources. against gram-positive organisms cefamandole showed great potency, being three- to four-fold more active than cephalexin or cefoxitin. none of the pseudomonas aeruginosa strains were susceptible to 100 μg of cefamandole per ml [1].

in vivo

the testicular toxicity of cefamandole was evaluated in neonatal rats. results showed that cefamandole caused delayed maturity of the germinal epithelium of neonatal rats. in rats given daily subcutaneous injections during this period, the most mature germinal cells were acrosome phase spermatids [2].

References

[1] eickhoff tc, ehret jm. in vitro comparison of cefoxitin, cefamandole, cephalexin, and cephalothin. antimicrob agents chemother. 1976 jun;9(6):994-9.
[2] hoover dm, buening mk, tamura rn, steinberger e. effects of cefamandole on spermatogenic development of young cd rats. fundam appl toxicol. 1989 nov;13(4):737-46.
[3] delgado dg, brau cj, cobbs cg, dismukes we. clinical and laboratory evaluation of cefamandole in the therapy of haemophilus spp. bronchopulmonary infections. antimicrob agents chemother. 1979 jun;15(6):807-12.

Sodium cefamandole Preparation Products And Raw materials

Raw materials

Preparation Products

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Sodium cefamandole Suppliers

Canada 1 China 77 Europe 1 Germany 1 India 2 South Korea 1 Switzerland 1 United Kingdom 2 United States 18 Global 104

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View Lastest Price from Sodium cefamandole manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: Sodium cefamandole 30034-03-8
Price: US $0.00-0.00/Kg
Min. Order: 1KG
Purity: 99.0%+
Supply Ability: 300 MT
Release date: 2020-05-23

Career Henan Chemical Co

Product: Sodium cefamandole 30034-03-8
Price: US $3.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1kg,5kg,50kg
Release date: 2020-01-18

30034-03-8, Sodium cefamandoleRelated Search:

Sodium gluconate Acetaminophen Cefamandole Sodium acetate Diclofenac sodium Sodium formate Sodium hydroxide Sodium chloride Sodium bicarbonate Sodium benzoate 1H-TETRAZOLE Cemandil sodium salt Cefonicid ACETAMINOPHENOL BP/USP Sodium cefamandole sodium 7-TMCA(inter.for cefamandole sodium,cefoperazone,cefpiramide)

(6R,7R)-7-[[(2R)-2-Hydroxy-2-phenylacetyl]amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid Sodium Salt

CEFAMANDOLE SODIUM

CEFAMANDOLE SODIUM SALT

5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylicacid,7-mandelamido-3-(((1-met

monosodiumsalt,d-hyl-1h-tetrazol-5-yl)thio)methyl)-8-oxo

(6R,7R)-7-[(R)-2-Hydroxy-2-phenylacetylamino]-3-(1-methyl-1H-tetrazol-5-ylthiomethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid sodium salt

Cephamandole sodium

Cefamandole Sodium (250 mg)

sodium [6r-[6alpha,7beta(r*)]]-7-[[(formyloxy)phenylacetyl]amino]-3-[[(1-methyl-1h-tetrazol-5-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

sodium (6r-(6alpha,7beta(r*)))-7-((hydroxyphenylacetyl)amino)-3-(((1-methyl-1h-tetrazol-5-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylate

sodium cefamandole

5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[(hydroxyphenylacetyl)amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-, monosodium salt, [6R-[6α,7β(R*)]]-

5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2R)-hydroxyphenylacetyl]amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-, monosodium salt, (6R,7R)-

5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-mandelamido-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-, monosodium salt, D- (8CI)

Sodium 7-D-mandelamido-3-(1-methyl-1H-tetrazol-5-ylthiomethyl)-3-cephem-4-carboxylate

Sodium cefamandole USP/EP/BP

30034-03-8

C18H17N6O5S2Na

C18H17N6NaO5S2

48448

BioChemical

Antibiotics

Antibiotics A to Z

Antibiotics A-F

A - KAntibiotics

Antibacterial

Antibiotics A to

Antibiotics A-FAntibiotics

Chemical Structure Class

Interferes with Cell Wall SynthesisAntibiotics

Mechanism of Action

Penicillins and Cephalosporins (beta-Lactams)

Spectrum of Activity

Nucleotides and Nucleosides

Bases & Related Reagents

Intermediates & Fine Chemicals

Nucleotides

Pharmaceuticals

Sulfur & Selenium Compounds