Sodium cefamandole
- Product Name
- Sodium cefamandole
- CAS No.
- 30034-03-8
- Chemical Name
- Sodium cefamandole
- Synonyms
- sodium cefamandole;CEFAMANDOLE SODIUM;Cephamandole sodium;CEFAMANDOLE SODIUM SALT;Cefamandole Sodium (250 mg);Sodium cefamandole USP/EP/BP;monosodiumsalt,d-hyl-1h-tetrazol-5-yl)thio)methyl)-8-oxo;5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylicacid,7-mandelamido-3-(((1-met;Sodium 7-D-mandelamido-3-(1-methyl-1H-tetrazol-5-ylthiomethyl)-3-cephem-4-carboxylate;5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-mandelamido-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-, monosodium salt, D- (8CI)
- CBNumber
- CB3744569
- Molecular Formula
- C18H17N6NaO5S2
- Formula Weight
- 484.48
- MOL File
- 30034-03-8.mol
Sodium cefamandole Property
- Melting point:
- >175°C (dec.)
- storage temp.
- Store at RT.
- solubility
- DMSO (Slightly), Methanol (Slightly), Water (Slightly)
- form
- Solid
- color
- White to Pale Yellow
- Stability:
- Moisture Sensitive
- CAS DataBase Reference
- 30034-03-8(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn
- Risk Statements
- 36/37/38-42/43
- Safety Statements
- 26-36
- WGK Germany
- 2
- RTECS
- XI0389000
- Toxicity
- mouse,LD50,intravenous,4460mg/kg (4460mg/kg),Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 26, Pg. 115, 1984.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H315Causes skin irritation
H317May cause an allergic skin reaction
H319Causes serious eye irritation
H334May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P272Contaminated work clothing should not be allowed out of the workplace.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P285In case of inadequate ventilation wear respiratory protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P341IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.
P342+P311IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P362Take off contaminated clothing and wash before reuse.
P363Wash contaminated clothing before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 18138
- Product name
- Cefamandole (sodium salt)
- Purity
- ≥95%
- Packaging
- 25mg
- Price
- $49
- Updated
- 2024/03/01
- Product number
- 18138
- Product name
- Cefamandole (sodium salt)
- Purity
- ≥95%
- Packaging
- 50mg
- Price
- $92
- Updated
- 2024/03/01
- Product number
- 18138
- Product name
- Cefamandole (sodium salt)
- Purity
- ≥95%
- Packaging
- 100mg
- Price
- $172
- Updated
- 2024/03/01
- Product number
- 18138
- Product name
- Cefamandole (sodium salt)
- Purity
- ≥95%
- Packaging
- 500mg
- Price
- $475
- Updated
- 2024/03/01
- Product number
- C237500
- Product name
- CefamandoleSodiumSalt
- Packaging
- 1g
- Price
- $605
- Updated
- 2021/12/16
Sodium cefamandole Chemical Properties,Usage,Production
Description
Cefamandole is a cephalosporin antibiotic that is effective against E. coli (MIC values range from 0.25-2 mg/L depending on strain) as well as H. influenza, S. pneumoniae, and S. aureus. It has been used to study the expression and inhibition of penicillin-binding proteins on bacterial cell walls and to study antibiotic resistance.
Chemical Properties
White Solid
Uses
Antibacterial;Bacterial transpeptidase inhibitor
Uses
Broad-spectrum semi-synthetic cephalosporin antibiotic.
Definition
ChEBI: An organic sodium salt that is the sodium salt of cefamandole.
in vitro
the in-vitro effect of cefamandole was tested against 645 strains of bacteria isolated from clinical sources. against gram-positive organisms cefamandole showed great potency, being three- to four-fold more active than cephalexin or cefoxitin. none of the pseudomonas aeruginosa strains were susceptible to 100 μg of cefamandole per ml [1].
in vivo
the testicular toxicity of cefamandole was evaluated in neonatal rats. results showed that cefamandole caused delayed maturity of the germinal epithelium of neonatal rats. in rats given daily subcutaneous injections during this period, the most mature germinal cells were acrosome phase spermatids [2].
References
[1] eickhoff tc, ehret jm. in vitro comparison of cefoxitin, cefamandole, cephalexin, and cephalothin. antimicrob agents chemother. 1976 jun;9(6):994-9.
[2] hoover dm, buening mk, tamura rn, steinberger e. effects of cefamandole on spermatogenic development of young cd rats. fundam appl toxicol. 1989 nov;13(4):737-46.
[3] delgado dg, brau cj, cobbs cg, dismukes we. clinical and laboratory evaluation of cefamandole in the therapy of haemophilus spp. bronchopulmonary infections. antimicrob agents chemother. 1979 jun;15(6):807-12.
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Raw materials
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View Lastest Price from Sodium cefamandole manufacturers
- Product
- Sodium cefamandole 30034-03-8
- Price
- US $0.00-0.00/Kg
- Min. Order
- 1KG
- Purity
- 99.0%+
- Supply Ability
- 300 MT
- Release date
- 2020-05-23
- Product
- Sodium cefamandole 30034-03-8
- Price
- US $3.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1kg,5kg,50kg
- Release date
- 2020-01-18