D-1-N-BOC-PROLINAMIDE

Product Name: D-1-N-BOC-PROLINAMIDE
CAS No.: 70138-72-6
Chemical Name: D-1-N-BOC-PROLINAMIDE
Synonyms: 2-carbamoyL;D-N-BOC-PROLINAMIDE;1-BOC-D-PROLINAMIDE;N-ALPHA-BOC-D-PROLINEAMIDE;(Tert-Butoxy)Carbonyl D-Pro-NH2;(R)-2-CARBAMOYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;1-Pyrrolidinecarboxylicacid, 2-(aminocarbonyl)-, 1,1-dimethy...;(2R)-2-carbamoyl-pyrrolidine-1-carboxylic acid tert-butyl ester;1-Pyrrolidinecarboxylic acid, 2-(aminocarbonyl)-, 1,1-dimethylethyl ester, (2R)-
CBNumber: CB5284601
Molecular Formula: C10H18N2O3
Formula Weight: 214.26
MOL File: 70138-72-6.mol

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D-1-N-BOC-PROLINAMIDE Property

Melting point:: 100-102 °C
Boiling point:: 370.1±31.0 °C(Predicted)
Density: 1.155±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 15.97±0.20(Predicted)
Appearance: White to off-white Solid
CAS DataBase Reference: 70138-72-6(CAS DataBase Reference)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H317May cause an allergic skin reaction

H319Causes serious eye irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Matrix Scientific

Product number: 075206
Product name: (R)-tert-Butyl 2-carbamoylpyrrolidine-1-carboxylate
Purity: 95+%
Packaging: 1g
Price: $14
Updated: 2021/12/16

AK Scientific

Product number: U909
Product name: D-N-Boc-prolinamide
Packaging: 1g
Price: $21
Updated: 2021/12/16

Matrix Scientific

Product number: 075206
Product name: (R)-tert-Butyl 2-carbamoylpyrrolidine-1-carboxylate
Purity: 95+%
Packaging: 5g
Price: $36
Updated: 2021/12/16

AK Scientific

Product number: J53342
Product name: D-N-Boc-prolinamide
Packaging: 5g
Price: $37
Updated: 2021/12/16

Matrix Scientific

Product number: 075206
Product name: (R)-tert-Butyl 2-carbamoylpyrrolidine-1-carboxylate
Purity: 95+%
Packaging: 10g
Price: $66
Updated: 2021/12/16

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D-1-N-BOC-PROLINAMIDE Chemical Properties,Usage,Production

Synthesis

37784-17-1

70138-72-6

General procedure for the synthesis of tert-butyl (R)-2-carbamoylpyrrolidine-1-carboxylate from Boc-D-proline: Example 1; Synthesis of tert-butyl (R)-2-carbamoylpyrrolidine-1-carboxylate. N-Methylmorpholine (9.85 g, 97.5 mmol) and isobutyl chloroformate (13.3 g, 97.5 mmol) were added to a THF solution (98 mL) of (R)-pyrrolidine-1,2-dicarboxylic acid 1- tert-butyl ester (20.0 g, 92.9 mmol) at -78 °C and stirred for 1 hour. Ammonium hydroxide (58 mL) was slowly added while the reaction system was warmed to room temperature and stirring was continued for 2 hours. Upon completion of the reaction, the reaction mixture was partitioned between dichloromethane and water. The organic phase was washed with 1 M HCl, dried over anhydrous sodium sulfate, filtered and concentrated to give the title product (10.8 g, 54%) as a colorless semi-solid.1H NMR (300 MHz, CDCl3): δ (ppm) 5.91-6.13 (m, 1H), 4.17-4.30 (m, 2H), 3.37-3.48 (m, 2H), 2.10- 2.18 (m, 2H), 1.84-1.96 (m, 2H), 1.45 (s, 9H).

References

[1] Patent: US2007/259926, 2007, A1. Location in patent: Page/Page column 9
[2] Tetrahedron, 2009, vol. 65, # 46, p. 9536 - 9541

D-1-N-BOC-PROLINAMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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D-1-N-BOC-PROLINAMIDE Suppliers

China 90 France 1 Germany 2 India 1 Japan 1 United Kingdom 6 United States 17 Global 118

J & K SCIENTIFIC LTD.

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AstaTech (Chengdu) Pharma. Co., Ltd.

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Amatek Scientific Co. Ltd.

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View Lastest Price from D-1-N-BOC-PROLINAMIDE manufacturers

Career Henan Chemical Co

Product: D-1-N-BOC-PROLINAMIDE 70138-72-6
Price: US $100.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: Customized
Release date: 2018-07-31

70138-72-6, D-1-N-BOC-PROLINAMIDERelated Search:

D-1-N-Boc-prolinamide D-Prolinamide

1-Pyrrolidinecarboxylic acid, 2-(aminocarbonyl)-, 1,1-dimethylethyl ester, (2R)-

(R)-2-CARBAMOYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

1-BOC-D-PROLINAMIDE

D-N-BOC-PROLINAMIDE

N-ALPHA-BOC-D-PROLINEAMIDE

(2R)-2-carbamoyl-pyrrolidine-1-carboxylic acid tert-butyl ester

(Tert-Butoxy)Carbonyl D-Pro-NH2

2-carbamoyL

1-Pyrrolidinecarboxylicacid, 2-(aminocarbonyl)-, 1,1-dimethy...

70138-72-6

C10H18N3O3

Pyrrole&Pyrrolidine&Pyrroline