D-1-N-Boc-prolinamide

Product Name: D-1-N-Boc-prolinamide
CAS No.: 35150-07-3
Chemical Name: D-1-N-Boc-prolinamide
Synonyms: BOC-PRO-NH2;1-Boc-D-proL;BOC-L-PRO-NH2;BOC-PYRD(2)-NH2;Boc-Proliniamide;BOC-L-PROLINAMIDE;Boc-D-Prolinamide;N-Boc-Prolinamide;BOC-D-PROLINEAMIDE;BOC-L-PROLINE AMIDE
CBNumber: CB8284602
Molecular Formula: C10H18N2O3
Formula Weight: 214.26
MOL File: 35150-07-3.mol

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D-1-N-Boc-prolinamide Property

Melting point:: 104-108 °C
Boiling point:: 370.1±31.0 °C(Predicted)
Density: 1.155±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
pka: 15.97±0.20(Predicted)
form: powder to crystal
color: White to Almost white
optical activity: Consistent with structure
CAS DataBase Reference: 35150-07-3(CAS DataBase Reference)

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Safety

Hazard Codes: Xn
Risk Statements: 22
Safety Statements: 24/25
WGK Germany: 2
HS Code: 2933.99.9701

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P330Rinse mouth.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 661198
Product name: 1-Boc-L-prolinamide
Purity: 97%
Packaging: 1g
Price: $69.5
Updated: 2023/06/20

Sigma-Aldrich

Product number: 661198
Product name: 1-Boc-L-prolinamide
Purity: 97%
Packaging: 5g
Price: $323
Updated: 2023/06/20

TCI Chemical

Product number: B3756
Product name: N-(tert-Butoxycarbonyl)-L-prolinamide
Purity: >98.0%(HPLC)(N)
Packaging: 1g
Price: $26
Updated: 2025/07/31

TCI Chemical

Product number: B3756
Product name: N-(tert-Butoxycarbonyl)-L-prolinamide
Purity: >98.0%(HPLC)(N)
Packaging: 5g
Price: $34
Updated: 2025/07/31

TRC

Product number: B664100
Product name: 1-Boc-L-Prolinamide
Packaging: 100mg
Price: $50
Updated: 2021/12/16

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D-1-N-Boc-prolinamide Chemical Properties,Usage,Production

Chemical Properties

White to off-white powder

Uses

1-Boc-L-prolinamide is a reagent that is used in the preparation of thiazole amide peptidomimetics as erratum inhibitor apoptosis protein antagonist.

reaction suitability

reaction type: Boc solid-phase peptide synthesis

Synthesis

15761-39-4

35150-07-3

GENERAL METHOD: BOC-L-proline (1.00 g, 4.65 mmol), di-tert-butyl dicarbonate (1.52 g, 6.97 mmol), ammonium bicarbonate (0.55 g, 6.97 mmol), and pyridine (1.0 mL) were dissolved in dioxane (20 mL), and the reaction was stirred at room temperature for 6 hours. After completion of the reaction, the product was extracted with dichloromethane, the organic phase was washed sequentially with 1 M hydrochloric acid and saturated sodium chloride solution, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. To the concentrate was added n-hexane (100 mL) and sonication prompted the product to precipitate as a white solid to afford N-tert-butoxycarbonyl-L-prolinamide (0.85 g, 85% yield). The product was characterized by 1H NMR (300 MHz, CDCl3): δ 4.37-4.34 (m, 1H), 3.47-3.36 (m, 2H), 2.07-1.85 (m, 4H), 1.49 (s, 9H). Mass spectrum (ESI) m/z 215 [M + H]+.

References

[1] Bioorganic and Medicinal Chemistry, 2002, vol. 10, # 6, p. 1719 - 1729
[2] Canadian Journal of Chemistry, 2007, vol. 85, # 2, p. 85 - 95
[3] Journal of Agricultural and Food Chemistry, 2012, vol. 60, # 35, p. 8544 - 8551
[4] Journal of Medicinal Chemistry, 2017, vol. 60, # 1, p. 228 - 247
[5] Bioorganic and Medicinal Chemistry, 2013, vol. 21, # 23, p. 7418 - 7429

D-1-N-Boc-prolinamide Preparation Products And Raw materials

Raw materials

Preparation Products

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D-1-N-Boc-prolinamide Suppliers

Americas 1 China 224 Europe 1 Germany 6 India 25 Italy 1 Japan 3 Switzerland 3 United Kingdom 4 United States 36 Global 304

Shanghai Boyle Chemical Co., Ltd.

Tel: 021-50182298 021-50180596
Fax: +86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2208
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J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
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Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006356688 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
Advantage: 62

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30123
Advantage: 84

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
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Energy Chemical

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Wuhan Chemwish Technology Co., Ltd

Tel: 86-027-67849912
Fax: 86-027-87531808
Email: sales@chemwish.com
Country: China
ProdList: 35896
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GL Biochem (Shanghai) Ltd

Tel: 21-61263452 13641803416
Fax: 86-21-61263399
Email: ymbetter@glbiochem.com
Country: China
ProdList: 9981
Advantage: 64

Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
Fax: 0086-571-85864795
Country: China
ProdList: 18207
Advantage: 66

Shanghai Sinch Parmaceuticals Tech. Co. Ltd.

Tel: +86-21-54098501
Fax: +86-21-54096319
Email: sales@sinch.com.cn
Country: China
ProdList: 11598
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View Lastest Price from D-1-N-Boc-prolinamide manufacturers

Shaanxi Didu New Materials Co. Ltd

Product: D-1-N-Boc-prolinamide 35150-07-3
Price: US $1.50/g
Min. Order: 1g
Purity: 99.0% Min
Supply Ability: 100 Tons
Release date: 2025-09-25

Career Henan Chemical Co

Product: D-1-N-Boc-prolinamide 35150-07-3
Price: US $100.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: Customized
Release date: 2018-07-31

35150-07-3, D-1-N-Boc-prolinamideRelated Search:

2-Butoxyethanol Butylparaben Diisobutyl phthalate Butyl acetate RESMETHRIN tert-Butanol tert-Butyl carbazate Cyhalofop-butyl Buprofezin L-Prolinamide Polyvinylpyrrolidone Isobutyl chloroformate BOC-L-Proline RAC 1-METHYL-PYRROLIDINE-2-CARBONITRILE CHLOROAC-PRO-OH (S)-2-THIOCARBAMOYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Butyl acrylate (S)-1-N-Boc-2-methylpiperazine

BOC-L-PROLINAMIDE

BOC-L-PRO-NH2

BOC-L-PROLINE AMIDE

BOC-PYRD(2)-NH2

BOC-PRO-NH2

L-1-N-Bocprolidinamid

tert-butyl (2S)-2-carbamoylpyrrolidine-1-carboxylate

1-Pyrrolidinecarboxylic acid, 2-(aminocarbonyl)-, 1,1-dimethylethyl ester, (2S)-

N-Boc-L-Prolinamide

(S)-N-BOC-Pyrrolidine-2-carboxamide

Vildagliptin Impurity 16

(S)-Boc-pyrrolidine-2-carboxylic acid amide

Boc-L-proline amide≥ 99% (HPLC)

N-Boc-L-prolinamide,99%e.e.

tert-Butyl (S)-2-carbamoylpyrrolidine-1-carboxylate

(Tert-Butoxy)Carbonyl Pro-NH2

L-1-N-BOC-PROLIDINAMIDE

(L)-1-N-BOC-PROLINAMIDE

Boc-D-Prolinamide

D-1-N-Boc-prolinamide

tert-Butyl (2R)-2-carbamoylpyrrolidine-1-carboxylate

1-BOC-L-PROLINAMIDE

(S)-2-(AMINOCARBONYL)-1-PYRROLIDINECARBOXYLIC ACID, 1,1-DIMETHYLETHYL ESTER

(S)-2-CARBAMOYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

N-ALPHA-T-BUTYLOXYCARBONYL-L-PROLINE AMIDE

N-ALPHA-T-BUTOXYCARBONYL-L-PYRROLIDINE-2-CARBOXYLIC ACID AMIDE

N-ALPHA-T-BUTOXYCARBONYL-L-PROLINE AMIDE

N-ALPHA-TERT-BUTYLOXYCARBONYL-L-PROLINE AMIDE

N-(TERT-BUTOXYCARBONYL)PROLINE AMIDE

N-TERT-BUTOXYCARBONYL-L-PROLINE AMIDE

DL-1-BOC-PROLINAMIDE

N-alpha-t-Butyloxycarbonyl-D-proline amide

N-ALPHA-BOC-L-PROLINEAMIDE

BOC-D-PROLINEAMIDE

N-(tert-Butoxycarbonyl)proline amide, (S)-2-(Aminocarbonyl)-1-pyrrolidinecarboxylic acid, 1,1-dimethylethyl ester

(R)-tert-butyl 2-carbamoylpyrrolidine-1-carboxylate

N-(tert-Butoxycarbonyl)-L-prolinaMide

Boc-Proliniamide

N-(tert-Butoxycarbonyl)-L-prolinamide &gt

1-Boc-D-proL

(S)-2-Carbamoyl-1-pyrrolidinecarboxylic Acid tert-Butyl Ester

tert-Butyl (S)-2-Carbamoyl-1-pyrrolidinecarboxylate

D-1-N-Boc-prolinamide USP/EP/BP

N-Boc-Prolinamide

BOC-L-Prolinamide extrapure, 98%

1,1-Dimethylethyl (2S)-2-(aminocarbonyl)-1-pyrrolidinecarboxylate

1-Boc-<sc>L</sc>-prolinamide

35150-07-3

C10H18N2O3

Amino Acid Derivatives

Amino Acids

Pyrrole&Pyrrolidine&Pyrroline