2,3-Dihydro-1-benzofuran-2-carboxylic acid
- Product Name
- 2,3-Dihydro-1-benzofuran-2-carboxylic acid
- CAS No.
- 1914-60-9
- Chemical Name
- 2,3-Dihydro-1-benzofuran-2-carboxylic acid
- Synonyms
- AKOS BBS-00006837;2,3-Dihydro-2-benzofurancarboxylic Acid;2,3-dihydro-1-benzofuran-2-carboxylicaci;2,3-DIHYDRO-BENZOFURAN-2-CARBOXYLIC ACID;2-Benzofurancarboxylic acid, 2,3-dihydro-;2,3-Dihydrobenzo[b]furan-2-carboxylic acid;2,3-Dihydro-1-Benzofurane-2-CarboxylicAcid;2,3-DIHYDRO-1-BENZOFURAN-2-CARBOXYLIC ACID;(2-methyl-3-imidazo[1,2-a]pyridinyl)methanol;2,3-Dihydro-1-benzofuran-2-carboxylic acid, 2-Carboxy-2,3-dihydrobenzo[b]furan
- CBNumber
- CB5295409
- Molecular Formula
- C9H8O3
- Formula Weight
- 164.16
- MOL File
- 1914-60-9.mol
2,3-Dihydro-1-benzofuran-2-carboxylic acid Property
- Melting point:
- 116-118
- Boiling point:
- 340.5±31.0 °C(Predicted)
- Density
- 1.347±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- form
- solid
- pka
- 3.17±0.20(Predicted)
- color
- White to off-white
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 36/37/38-51-22
- Safety Statements
- 26-37/39
- Hazard Note
- Irritant
- HS Code
- 29321900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 082720
- Product name
- 2,3-Dihydro-1-benzofuran-2-carboxylic acid
- Packaging
- 1.00g
- Price
- $194
- Updated
- 2026/05/18
- Product number
- D9444
- Product name
- 2,3-Dihydrobenzofuran-2-carboxylic acid
- Purity
- 90+%
- Packaging
- 100mg
- Price
- $23
- Updated
- 2026/05/06
- Product number
- D9444
- Product name
- 2,3-Dihydrobenzofuran-2-carboxylic acid
- Purity
- 90+%
- Packaging
- 250mg
- Price
- $27
- Updated
- 2026/05/06
- Product number
- D9444
- Product name
- 2,3-Dihydrobenzofuran-2-carboxylic acid
- Purity
- 90+%
- Packaging
- 1g
- Price
- $29
- Updated
- 2026/05/06
- Product number
- D9444
- Product name
- 2,3-Dihydrobenzofuran-2-carboxylic acid
- Purity
- 90+%
- Packaging
- 5g
- Price
- $70
- Updated
- 2026/05/06
2,3-Dihydro-1-benzofuran-2-carboxylic acid Chemical Properties,Usage,Production
Chemical Properties
White solid
Uses
This compound is the starting material in the synthesis of (dihydro)benzofuran-2-carboxylic acid N-(substituted)phenylamide derivatives as anticancer agents.
Synthesis Reference(s)
Journal of Heterocyclic Chemistry, 24, p. 495, 1987 DOI: 10.1002/jhet.5570240236
Synthesis
496-41-3
1914-60-9
a) Synthesis of (R,S)-2,3-dihydro-benzofuran-2-carboxylic acid (54a): commercially available benzofuran-2-carboxylic acid (Aldrich Chemical Company, 27 g, 167.7 mmol) was dissolved in ethyl acetate (300 mL). The hydrogenation reaction was catalyzed by 10% Pd/C (20 g) at 65-70 psi hydrogen pressure for 2 days. Upon completion of the reaction, the catalyst was removed by filtration and the solvent was evaporated. A solvent mixture of ethyl acetate-hexane (1:6) was added to the residue for recrystallization. Filtration afforded benzodihydrofuran-2-carboxylic acid as a crystalline solid (20.23 g, 74% yield). Melting point: 116-117 °C. 1H NMR (300 MHz, CDCl3) δ: 11.05 (brs, 1H), 7.17 (m, 2H), 6.91 (m, 2H), 5.24 (dd, 1H), 3.63 (dd, 1H), 3.42 (dd, 1H).
References
[1] Patent: US2005/54630, 2005, A1. Location in patent: Page/Page column 42
[2] Justus Liebigs Annalen der Chemie, 1883, vol. 216, p. 169
[3] Chemische Berichte, 1906, vol. 39, p. 496
[4] Farmaco, 1998, vol. 53, # 12, p. 764 - 772
[5] Patent: US2008/200540, 2008, A1. Location in patent: Page/Page column 18
2,3-Dihydro-1-benzofuran-2-carboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2,3-Dihydro-1-benzofuran-2-carboxylic acid manufacturers
- Product
- 2,3-Dihydro-1-benzofuran-2-carboxylic acid 1914-60-9
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1kg,5kg,100kg
- Release date
- 2019-07-04