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Kasugamycin hydrochloride

Product Name
Kasugamycin hydrochloride
CAS No.
19408-46-9
Chemical Name
Kasugamycin hydrochloride
Synonyms
kasumin;Kasugamycin hy;KasugaMycin HCl;kasugamycin (jmaff);KASUGAMYCIN HYDROCHL;KASUGAMYCIN HCL HYDRATE;Ksugamycinhydrochloride;KASUGAMYCIN HYDROCHLORIDE;Kasugamycin HCl, Monohydrate;kasugamycin,monohydrochloride
CBNumber
CB5297221
Molecular Formula
C14H25N3O9.ClH
Formula Weight
415.82
MOL File
19408-46-9.mol
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Kasugamycin hydrochloride Property

Melting point:
202-204 °C (decomp)
vapor pressure 
<1.3x l0-8 Pa (25 °C)
storage temp. 
Sealed in dry,2-8°C
solubility 
H2O: soluble
pka
3.23 (carboxyl), 7.73 and 11.0 (bases)
Water Solubility 
125 g l-1 (25 °C)
form 
Solid
color 
white to off-white
Stability:
Hygroscopic
CAS DataBase Reference
19408-46-9(CAS DataBase Reference)
EPA Substance Registry System
Kasugamycin monohydrochloride (19408-46-9)
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Safety

Safety Statements 
22-24/25-26
WGK Germany 
2
RTECS 
NM7521800
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H320Causes eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
K4013
Product name
Kasugamycin hydrochloride from Streptomyces kasugaensis
Purity
≥90% (HPLC)
Packaging
10g
Price
$402
Updated
2024/03/01
Sigma-Aldrich
Product number
32354
Product name
Kasugamycin hydrochloride
Purity
VETRANAL
Packaging
100mg
Price
$69.5
Updated
2024/03/01
Alfa Aesar
Product number
J67325
Product name
Kasugamycin, 50 mg/ml in distilled water, sterile-filtered
Packaging
25ml
Price
$294
Updated
2023/06/20
Alfa Aesar
Product number
J67325
Product name
Kasugamycin, 50 mg/ml in distilled water, sterile-filtered
Packaging
50ml
Price
$340
Updated
2021/12/16
Cayman Chemical
Product number
15322
Product name
Kasugamycin (hydrochloride)
Purity
≥70%
Packaging
1g
Price
$48
Updated
2023/06/20
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Kasugamycin hydrochloride Chemical Properties,Usage,Production

Description

Kasugamycin is an aminoglycosidic antibiotic isolated from S. kasugaensis. It blocks the initiation of translation, preventing initiation complex formation on 30S ribosomes in bacteria.

Uses

antifungal

Uses

kasugamycin, derived from Streptomyces kasuguensis, is also used to control rice blast.It acts by inhibiting protein synthesis by interfering with the binding of aminoacyl-tRNA to the mRNA-30s ribosomal subunit complex (Yamaguchi, 1998).

Uses

Kasugamycin Hydrochloride is an aminoglycoside antibiotic that inhibits the initiation of translation. It is also a type of fungicide that controls leaf and neck blast disease caused by Pyricularia oryzae and increases rice yields.

in vitro

kasugamycin could inhibit protein synthesis by interacting with the 30s ribosomal subunit. the mechanism of inhibition of protein synthesis appeared to be different from that of other aminoglycosides, such as kanamycin, streptomycin, neomycin, gentamicin. the initiation complex formation on 30s ribosomes could be inhibited by kasugamycin but not by streptomycin, kanamycin or gentamicin, though the binding of fmet-trna to 70s ribosomes was inhibited by both streptomycin and by kasugamycin. [1].

in vivo

five groups, each consisting of five guinea pigs, were infected with shibaura strain; two groups were treated by injection with kasugamycin. all animals treated with 1 mcg/g were killed showing an average survival period of 7.4 days, which was close to the average survival period of 6.2 days in the control group; while all animals treated with 5 mcg/g survived. the other two groups were treated with kasugamycin from the icteric stage to the 10th day after infection. two animals of the 5 mcg/g group survived, showing no leptospira in the kidney; the other three died in an average of 7.7 days. three animals of the 10 mcg/g group survived; while the other two animals died in 6.5 days on an average . the total amounts of kasugamycin administered to the infected guinea pigs from the febrile stage were 10.8 mg (the 1 mcg/g group) and 54.0 mg (the 5 mcg/g group) [2].

Metabolic pathway

kasugamycin hydrochloride hydrate is a relatively stable antibiotic. There is limited published information on its metabolism and environmental fate but it is extensively degraded in plants and soil as indicated in Scheme 1.

Degradation

kasugamycin hydrochloride hydrate is very stable at room temperature. It is stable in weak acids but unstable in strong acids and under basic conditions. Its DT50 values at 50 °C are 47 and 14 days at pH 5 and 9, respectively (PM).

References

[1] okuyama, a. ,machiyama, n.,kinoshita, t., et al. inhibition by kasugamycin of initiation complex formation on 30s ribosomes. biochemical and biophysical research communications 43(1), 196-199 (1971).
[2] kitaoka m, mori m, arimitsu y. in vitro and in vivo effects of kasugamycin on leptospira icterohaemorrhagiae. jpn j med sci biol. 1975 oct-dec;28(5-6):285-90.

Kasugamycin hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Kasugamycin hydrochloride Suppliers

North China Pharmaceutical Huasheng Co., Ltd
Tel
0311-83090290
Fax
0311-83090280
Email
ncpchs@ncpchs.com
Country
China
ProdList
15
Advantage
60
XiaoGan ShenYuan ChemPharm co,ltd
Tel
15527768850
Email
1791901229@qq.com
Country
China
ProdList
8844
Advantage
52
Hangzhou Yuhao Chemical Technology Co., Ltd
Tel
0571-82693216
Fax
+86-571-82880190
Email
info@yuhaochemical.com
Country
China
ProdList
9387
Advantage
52
Chengdu Ai Keda Chemical Technology Co., Ltd.
Tel
4008-755-333 18080918076
Fax
028-86757656
Email
800078821@qq.com
Country
China
ProdList
9718
Advantage
55
AILY INTL CHEMICAL CORP LTD
Tel
025-83208295 18913388297
Fax
+86-2583208202
Email
ben@ailychem.com
Country
China
ProdList
132
Advantage
50
Beijing HuaMeiHuLiBiological Chemical
Tel
010-56205725
Fax
010-65763397
Email
waley188@sohu.com
Country
China
ProdList
12335
Advantage
58
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-400-6206333 18521732826
Fax
021-50323701
Email
market@aladdin-e.com
Country
China
ProdList
25003
Advantage
65
Nanjing Sunlida Biological Technology Co., Ltd.
Tel
025-57798810
Fax
025-57019371
Email
sales@sunlidabio.com
Country
China
ProdList
3239
Advantage
55
TargetMol Chemicals Inc.
Tel
021-021-33632979 15002134094
Fax
021-33632979
Email
marketing@targetmol.com
Country
China
ProdList
7783
Advantage
58
Shanghai TaoSu Biochemical Technology Co., Ltd.
Tel
021-33632979
Fax
021-34692979
Email
info@tsbiochem.com
Country
China
ProdList
8065
Advantage
58
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View Lastest Price from Kasugamycin hydrochloride manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Kasugamycin hydrochloride 19408-46-9
Price
US $0.00-0.00/Kg/Drum
Min. Order
1KG
Purity
70%min
Supply Ability
1000kg
Release date
2021-10-14
Hebei Weibang Biotechnology Co., Ltd
Product
Kasugamycin hydrochloride 19408-46-9
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2024-10-28
Hebei Yanxi Chemical Co., Ltd.
Product
Kasugamycin hydrochloride 19408-46-9
Price
US $10.00-1.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
10 tons
Release date
2023-09-15

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