Kasugamycin hydrochloride

ChemicalBook > CAS DataBase List > Kasugamycin hydrochloride

Kasugamycin hydrochloride

Product Name: Kasugamycin hydrochloride
CAS No.: 19408-46-9
Chemical Name: Kasugamycin hydrochloride
Synonyms: kasumin;Kasugamycin hy;KasugaMycin HCl;kasugamycin (jmaff);KASUGAMYCIN HYDROCHL;KASUGAMYCIN HCL HYDRATE;KASUGAMYCIN HYDROCHLORIDE;Kasugamycin HCl, Monohydrate;kasugamycin,monohydrochloride;KASUGAMYCIN HYDROCHLORIDE HYDRATE
CBNumber: CB5297221
Molecular Formula: C14H25N3O9.ClH
Formula Weight: 415.82
MOL File: 19408-46-9.mol

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Kasugamycin hydrochloride Property

Melting point:: 202-204 °C (decomp)
vapor pressure: <1.3x l0^-8 Pa (25 °C)
storage temp.: Sealed in dry,2-8°C
solubility: H₂O: soluble
pka: 3.23 (carboxyl), 7.73 and 11.0 (bases)
Water Solubility: 125 g l^-1 (25 °C)
color: white to off-white
Stability:: Hygroscopic
CAS DataBase Reference: 19408-46-9(CAS DataBase Reference)
EPA Substance Registry System: Kasugamycin monohydrochloride (19408-46-9)

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Safety

Safety Statements: 22-24/25-26
WGK Germany: 2
RTECS: NM7521800

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H320Causes eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: K4013
Product name: Kasugamycin hydrochloride from Streptomyces kasugaensis
Purity: ≥90% (HPLC)
Packaging: 10g
Price: $402
Updated: 2024/03/01

Sigma-Aldrich

Product number: 32354
Product name: Kasugamycin hydrochloride
Purity: VETRANAL
Packaging: 100mg
Price: $69.5
Updated: 2024/03/01

Alfa Aesar

Product number: J67325
Product name: Kasugamycin, 50 mg/ml in distilled water, sterile-filtered
Packaging: 25ml
Price: $294
Updated: 2023/06/20

Alfa Aesar

Product number: J67325
Product name: Kasugamycin, 50 mg/ml in distilled water, sterile-filtered
Packaging: 50ml
Price: $340
Updated: 2021/12/16

Cayman Chemical

Product number: 15322
Product name: Kasugamycin (hydrochloride)
Purity: ≥70%
Packaging: 1g
Price: $48
Updated: 2023/06/20

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Kasugamycin hydrochloride Chemical Properties,Usage,Production

Description

Kasugamycin is an aminoglycosidic antibiotic isolated from S. kasugaensis. It blocks the initiation of translation, preventing initiation complex formation on 30S ribosomes in bacteria.

Uses

antifungal

Uses

kasugamycin, derived from Streptomyces kasuguensis, is also used to control rice blast.It acts by inhibiting protein synthesis by interfering with the binding of aminoacyl-tRNA to the mRNA-30s ribosomal subunit complex (Yamaguchi, 1998).

Uses

Kasugamycin Hydrochloride is an aminoglycoside antibiotic that inhibits the initiation of translation. It is also a type of fungicide that controls leaf and neck blast disease caused by Pyricularia oryzae and increases rice yields.

in vitro

kasugamycin could inhibit protein synthesis by interacting with the 30s ribosomal subunit. the mechanism of inhibition of protein synthesis appeared to be different from that of other aminoglycosides, such as kanamycin, streptomycin, neomycin, gentamicin. the initiation complex formation on 30s ribosomes could be inhibited by kasugamycin but not by streptomycin, kanamycin or gentamicin, though the binding of fmet-trna to 70s ribosomes was inhibited by both streptomycin and by kasugamycin. [1].

in vivo

five groups, each consisting of five guinea pigs, were infected with shibaura strain; two groups were treated by injection with kasugamycin. all animals treated with 1 mcg/g were killed showing an average survival period of 7.4 days, which was close to the average survival period of 6.2 days in the control group; while all animals treated with 5 mcg/g survived. the other two groups were treated with kasugamycin from the icteric stage to the 10th day after infection. two animals of the 5 mcg/g group survived, showing no leptospira in the kidney; the other three died in an average of 7.7 days. three animals of the 10 mcg/g group survived; while the other two animals died in 6.5 days on an average . the total amounts of kasugamycin administered to the infected guinea pigs from the febrile stage were 10.8 mg (the 1 mcg/g group) and 54.0 mg (the 5 mcg/g group) [2].

Metabolic pathway

kasugamycin hydrochloride hydrate is a relatively stable antibiotic. There is limited published information on its metabolism and environmental fate but it is extensively degraded in plants and soil as indicated in Scheme 1.

Degradation

kasugamycin hydrochloride hydrate is very stable at room temperature. It is stable in weak acids but unstable in strong acids and under basic conditions. Its DT₅₀ values at 50 °C are 47 and 14 days at pH 5 and 9, respectively (PM).

References

[1] okuyama, a. ,machiyama, n.,kinoshita, t., et al. inhibition by kasugamycin of initiation complex formation on 30s ribosomes. biochemical and biophysical research communications 43(1), 196-199 (1971).
[2] kitaoka m, mori m, arimitsu y. in vitro and in vivo effects of kasugamycin on leptospira icterohaemorrhagiae. jpn j med sci biol. 1975 oct-dec;28(5-6):285-90.

Kasugamycin hydrochloride Preparation Products And Raw materials

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View Lastest Price from Kasugamycin hydrochloride manufacturers

Ouhuang Engineering Materials (Hubei) Co., Ltd

Product: Kasugamycin Hydrochloride 19408-46-9
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99.91%
Supply Ability: 200000
Release date: 2024-04-16

Hebei Duling International Trade Co. LTD

Product: Kasugamycin hydrochloride 19408-46-9
Price: US $1.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 5000 Ton
Release date: 2022-10-19

Shaanxi Dideu Medichem Co. Ltd

Product: Kasugamycin hydrochloride 19408-46-9
Price: US $1.00-1.00/KG
Min. Order: 1g
Purity: 99%
Supply Ability: 50tons
Release date: 2020-05-07

19408-46-9, Kasugamycin hydrochlorideRelated Search:

BISMERTHIAZOL Ethylicin Propineb KASUGAMYCIN HYDROCHLORIDE KASUGAMYCIN D-chiro-inositol Kasugamycin hydrochloride

KASUGAMYCIN HYDROCHLORIDE HYDRATE

KASUGAMYCIN HYDROCHL

KasugaMycin HCl

Kasugamycin hy

3-O-[2-Amino-4-[(carboxyiminomethyl)amino]-2,3,4,6-tetradeoxy-D-arabino-hexopyranosyl]-D-chiro-inositol hydrochloride

Kasugamycin hydrochloride, ≥90% (HPLC)

KASUGAMYCIN HCL HYDRATE

(5-amino-2-methyl-6-(2,3,4,5,6-pentahydroxycyclohexyloxy)tetrahydropryan-3-yl)amino-alpha-iminoaceti

3-o-(2-amino-4-((carboxyiminomethyl)amino)-2,3,4,6-tetradeoxy-alpha-d-arabino-hexopyranosyl)-d-chiro-inositomonohydrochloride

kasugamycin,monohydrochloride

kasumin

3-o-[2-amino-4-[(carboxyiminomethyl)amino]-2,3,4,6-tetradeoxy-d-arabino-hexopyranosyl]-d-chiro-inositol

kasugamycin (jmaff)

kasugamycin hydrochloride from streptomyces kasugaensis

(5-amino-2-methyl-6-(2,3,4,5,6-pentahydroxycyclohexyloxy)tetrahydropryan-3-yl)amino-alpha-iminoacetic acid

3-o-(2-amino-4-((carboxyiminomethyl)amino)-2,3,4,6-tetradeoxy-alpha-d-arabino-hexopyranosyl)-d-chiro-inosito monohydrochloride

2-(((2R,3S,5S,6R)-5-Amino-2-methyl-6-(((1R,2R,3S,4R,5S,6S)-2,3,4,5,6-pentahydroxycyclohexyl)oxy)tetrahydro-2H-pyran-3-yl)amino)-2-iminoacetic acid hydrochloride

KASUGAMYCIN HYDROCHLORIDE

Kasugamycinhydrochloride Solution in Methanol/Water, 100μg/mL

Kasugamycin hydrochloride Solution in Methanol/Water, 1000μg/mL

Kasugamycin hydrochloride USP/EP/BP

Kasugamycin HCl, Monohydrate

D-chiro-Inositol,3-O-[2-amino-4-[(carboxyiminomethyl)amino]-2,3,4,6-tetradeoxy-a-D-arabino-hexopyranosyl]-, monohydrochloride

19408-46-9

C14H25N3O9

C14H26ClN3O9

C14H25N3O9HClH2O

C14H28ClN3O10

FUNGICIDE

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