Ethyl 5-chloro-4-nitrothiophene-2-carboxylate
- Product Name
- Ethyl 5-chloro-4-nitrothiophene-2-carboxylate
- CAS No.
- 89640-03-9
- Chemical Name
- Ethyl 5-chloro-4-nitrothiophene-2-carboxylate
- Synonyms
- 2-Thiophenecarboxylic acid, 5-chloro-4-nitro-, ethyl ester
- CBNumber
- CB53037644
- Molecular Formula
- C7H6ClNO4S
- Formula Weight
- 235.64
- MOL File
- 89640-03-9.mol
Ethyl 5-chloro-4-nitrothiophene-2-carboxylate Property
- Melting point:
- 47-48 °C
- Boiling point:
- 358.2±37.0 °C(Predicted)
- Density
- 1.499±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- Appearance
- Yellow to orange Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 8995DM
- Product name
- Ethyl5-chloro-4-nitrothiophene-2-carboxylate
- Packaging
- 5g
- Price
- $213
- Updated
- 2021/12/16
- Product number
- 071996
- Product name
- Ethyl 5-chloro-4-nitrothiophene-2-carboxylate
- Purity
- 95+%
- Packaging
- 1g
- Price
- $231
- Updated
- 2021/12/16
- Product number
- 071996
- Product name
- Ethyl 5-chloro-4-nitrothiophene-2-carboxylate
- Purity
- 95+%
- Packaging
- 5g
- Price
- $700
- Updated
- 2021/12/16
- Product number
- 071996
- Product name
- Ethyl 5-chloro-4-nitrothiophene-2-carboxylate
- Purity
- 95+%
- Packaging
- 10g
- Price
- $893
- Updated
- 2021/12/16
- Product number
- CM255634
- Product name
- Ethyl5-chloro-4-nitrothiophene-2-carboxylate
- Purity
- 95%
- Packaging
- 25g
- Price
- $341
- Updated
- 2021/12/16
Ethyl 5-chloro-4-nitrothiophene-2-carboxylate Chemical Properties,Usage,Production
Synthesis
5751-82-6
89640-03-9
General procedure for the synthesis of methyl 5-chloro-4-nitrothiophene-2-carboxylate from ethyl 5-chlorothiophene-2-carboxylate: ethyl 5-chlorothiophene-2-carboxylate (2.7 g, 14.1 mmol) was added in batches to concentrated sulfuric acid (5 mL) and the stirred solution was cooled to below 0 °C under methanol/ice bath conditions. Fuming nitric acid (1.78 g, 1.2 mL, 28.3 mmol) was added slowly and dropwise, ensuring that the reaction temperature was maintained below 0 °C throughout the addition. After addition, the stirred mixture was removed from the cold bath and stirred for 2 h at room temperature. Upon completion of the reaction, the reaction was quenched by the addition of an ice-water mixture (100 mL), at which point the formation of a viscous solid was observed. The product was extracted with dichloromethane (2 x 100 mL) and the organic phases were combined and dried over anhydrous magnesium sulfate. After filtration, the solvent was removed under reduced pressure to give an orange oily crude product. The crude product was purified by silica gel column chromatography using a solvent mixture of hexane and ethyl acetate (95:5, v/v) as eluent, resulting in the title compound methyl 5-chloro-4-nitrothiophene-2-carboxylate as a solid (2.23 g, 67% yield).1H NMR (CDCl3) δ: 8.14 (1H, s), 4.37 (2H, q, J = 7.11 Hz ), 1.37 (3H, t, J = 7.11 Hz).
References
[1] Patent: WO2010/114881, 2010, A1. Location in patent: Page/Page column 43-44
[2] Patent: WO2008/133753, 2008, A2. Location in patent: Page/Page column 126
Ethyl 5-chloro-4-nitrothiophene-2-carboxylate Preparation Products And Raw materials
Raw materials
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View Lastest Price from Ethyl 5-chloro-4-nitrothiophene-2-carboxylate manufacturers
- Product
- Ethyl 5-chloro-4-nitrothiophene-2-carboxylate 89640-03-9
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
- Product
- Ethyl 5-chloro-4-nitrothiophene-2-carboxylate 89640-03-9
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09