E6446 (dihydrochloride)

Product Name: E6446 (dihydrochloride)
CAS No.: 1345675-25-3
Chemical Name: E6446 (dihydrochloride)
Synonyms: CS-2089;E6446 HCl;E6446 2HCl;E-6446 DihydrochL;E6446;E 6446;E-6446;E6446 hydrochloride;E6446 (dihydrochloride);E6446 dihydrochloride,E-6446 dihydrochloride;6-(3-(Pyrrolidin-1-yl)propoxy)-2-(4-(3-(pyrrolidin-1-yl)propoxy)phenyl)benzo[d]oxazole dihydrochloride
CBNumber: CB53041403
Molecular Formula: C27H36ClN3O3
Formula Weight: 486.05
MOL File: 1345675-25-3.mol

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E6446 (dihydrochloride) Property

storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: DMSO:7.5(Max Conc. mg/mL);14.35(Max Conc. mM)
DMF:20.0(Max Conc. mg/mL);38.28(Max Conc. mM)
DMF:PBS (pH 7.2) (1:4):0.2(Max Conc. mg/mL);0.38(Max Conc. mM)
Ethanol:2.0(Max Conc. mg/mL);3.83(Max Conc. mM)
Water:100.0(Max Conc. mg/mL);191.38(Max Conc. mM)
form: Solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

AK Scientific

Product number: 3422DW
Product name: E6446(Dihydrochloride)
Packaging: 2mg
Price: $147
Updated: 2021/12/16

AK Scientific

Product number: 3422DW
Product name: E6446(Dihydrochloride)
Packaging: 1g
Price: $1906
Updated: 2021/12/16

Crysdot

Product number: CD31003814
Product name: E6446dihydrochloride
Purity: 98+%
Packaging: 50mg
Price: $2072
Updated: 2021/12/16

Ambeed

Product number: A119560
Product name: E-6446Dihydrochloride
Purity: 98%
Packaging: 1g
Price: $8397
Updated: 2021/12/16

Arctom

Product number: AS439180
Product name: E-6446Dihydrochloride
Purity: 98%
Packaging: 2mg
Price: $176
Updated: 2021/12/16

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E6446 (dihydrochloride) Chemical Properties,Usage,Production

Uses

E6446 is a synthetic antagonist of nucleic acid-sensing TLRs. , In vitro, low doses of E6446 specifically inhibited the activation of human and mouse TLR9. Tenfold higher concentrations of this compound also inhibited the human TLR8 response to single-stranded RNA. In vivo, therapy with E6446 diminished the activation of TLR9 and prevented the exacerbated cytokine response observed during acute Plasmodium infection. Furthermore, severe signs of ECM, such as limb paralysis, brain vascular leak, and death, were all prevented by oral treatment with E6446.

E6446 (dihydrochloride) Preparation Products And Raw materials

Raw materials

Preparation Products

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E6446 (dihydrochloride) Suppliers

China 36 India 1 United States 7 Global 44

Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.

Tel: 025-66099280 17798518460
Fax: (1)02557626880
Email: cfzhang@aikonchem.com
Country: China
ProdList: 19915
Advantage: 55

Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 41462
Advantage: 60

Guangzhou QiYun Biotechnology Co., Ltd.

Tel: 020-61288194 61288195
Fax: 020-61288700
Email: 505721671@qq.com
Country: China
ProdList: 3866
Advantage: 58

Tianjin Kailiqi Biotechnology Co., Ltd.

Tel: 15076683720
Fax: 022-23754520
Email: klq@cw-bio.com
Country: China
ProdList: 4602
Advantage: 55

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 18892239720
Fax: 010-60605840
Email: psaitong@jm-bio.com
Country: China
ProdList: 12306
Advantage: 58

Zhengzhou Huiju Chemical Co., Ltd.

Tel: 0371-55900031 18137872243
Fax: QQ：2853979815
Email: 2853979815@qq.com
Country: China
ProdList: 10008
Advantage: 55

Angel Pharmatech, Ltd.

Tel: 17317130613
Fax: QQ3358272972
Email: 3358272972@qq.com
Country: China
ProdList: 3251
Advantage: 58

Fan De(Beijing) Biotechnology Co., Ltd.

Tel: 15911056312
Email: liming@bio-fount.com
Country: China
ProdList: 9729
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32165
Advantage: 58

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View Lastest Price from E6446 (dihydrochloride) manufacturers

Career Henan Chemical Co

Product: E6446 (dihydrochloride) 1345675-25-3
Price: US $1.00/g
Min. Order: 1g
Purity: 99。99%
Supply Ability: 200kg
Release date: 2019-12-24

1345675-25-3, E6446 (dihydrochloride)Related Search:

E6446 (dihydrochloride)

E6446 2HCl

E6446 HCl

E6446 hydrochloride

CS-2089

E6446;E 6446;E-6446

E-6446 DihydrochL

6-(3-(Pyrrolidin-1-yl)propoxy)-2-(4-(3-(pyrrolidin-1-yl)propoxy)phenyl)benzo[d]oxazole dihydrochloride

E6446 dihydrochloride,E-6446 dihydrochloride

1345675-25-3

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