ChemicalBook > CAS DataBase List > RSV604

RSV604

Product Name: RSV604
CAS No.: 676128-63-5
Chemical Name: RSV604
Synonyms: RSV604;CS-2092;RSV604;RSV 604;RSV604, 10 mM in DMSO;Urea, N-[(3S)-2,3-dihydro-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl]-N'-(2-fluorophenyl)-;(S)-1-(2-fluoro-phenyl)-3-(2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-urea;virus,Respiratory syncytial virus,A 60444,respiratory,protein,inhibit,RSV,syncytial,A-60444,Inhibitor,A60444,RSV604,RSV 604,nucleocapsid,RSV-604
CBNumber: CB53041458
Molecular Formula: C22H17FN4O2
Formula Weight: 388.39
MOL File: 676128-63-5.mol

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RSV604 Property

storage temp.: Store at -20°C
solubility: DMF: 30 mg/ml; DMF:PBS (pH 7.2) (1:20): 0.04 mg/ml; DMSO: 20 mg/ml; Ethanol: 5 mg/ml
form: A solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1695
Product name: RSV604
Purity: ≥98% (HPLC)
Packaging: 5 mg
Price: $94.4
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML1695
Product name: RSV604
Purity: ≥98% (HPLC)
Packaging: 25 mg
Price: $380
Updated: 2025/07/31

Cayman Chemical

Product number: 29041
Product name: RSV-604
Packaging: 5mg
Price: $100
Updated: 2024/03/01

Cayman Chemical

Product number: 29041
Product name: RSV-604
Packaging: 25mg
Price: $381
Updated: 2024/03/01

Cayman Chemical

Product number: 29041
Product name: RSV-604
Packaging: 1mg
Price: $32
Updated: 2024/03/01

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RSV604 Chemical Properties,Usage,Production

Uses

RSV604 (A-60444) is an inhibitor of respiratory syncytial virus (RSV) replication. RSV604 targets the nucleocapsid protein, with a Kd of 1.6 μM. RSV604 displays submicromolar activity against numerous clinical isolates of both the A and B subtypes of RSV (average EC50s=0.8 μM)[1][2].

Biological Activity

RSV604 (A-60444), a novel benzodiazepine, is an inhibitor of respiratory syncytial virus (RSV) with EC50 of 0.86 μM. It has the potential to treat RSV-related diseases. Phase 2.

in vitro

RSV604 (5 days) inhibits the growth of four laboratory strains of RSV (RSS, Long, A2 and B), with EC ₅₀ s ranging from 0.5 to 0.9 μM in plaque reduction assay.
It (6 days) inhibits RSV-induced HEp-2 cell death, with an EC ₅₀ of 0.86 μM.
Also RSV604 (3 days) reduces viral antigen synthesis in RSV-infected HEp-2 cells, with an EC ₅₀ of 1.7 μM.
RSV604 (1-20 μM; 7 days) dose-dependently inhibits RSV infection in human airway epithelial (HAE) cells, with no gross cytotoxicity, leakage of basolateral fluid to the apical surface, or alteration of cilium beat frequency.

target

Target	Value
RSV (Cell-free assay)	0.86 μM(EC50)

References

[1] Chapman J, et al. RSV604, a novel inhibitor of respiratory syncytial virus replication. Antimicrob Agents Chemother. 2007 Sep;51(9):3346-53. DOI:10.1128/AAC.00211-07
[2] Challa S, et al. Mechanism of action for respiratory syncytial virus inhibitor RSV604. Antimicrob Agents Chemother. 2015 Feb;59(2):1080-7. DOI:10.1128/AAC.04119-14

RSV604 Preparation Products And Raw materials

Raw materials

Preparation Products

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676128-63-5, RSV604Related Search:

RSV604

(S)-1-(2-fluoro-phenyl)-3-(2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-urea

RSV604;RSV 604

CS-2092

Urea, N-[(3S)-2,3-dihydro-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl]-N'-(2-fluorophenyl)-

virus,Respiratory syncytial virus,A 60444,respiratory,protein,inhibit,RSV,syncytial,A-60444,Inhibitor,A60444,RSV604,RSV 604,nucleocapsid,RSV-604

RSV604, 10 mM in DMSO

676128-63-5