RSV604
- Product Name
- RSV604
- CAS No.
- 676128-63-5
- Chemical Name
- RSV604
- Synonyms
- RSV604;CS-2092;RSV604;RSV 604;Urea, N-[(3S)-2,3-dihydro-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl]-N'-(2-fluorophenyl)-;(S)-1-(2-fluoro-phenyl)-3-(2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-urea;virus,Respiratory syncytial virus,A 60444,respiratory,protein,inhibit,RSV,syncytial,A-60444,Inhibitor,A60444,RSV604,RSV 604,nucleocapsid,RSV-604
- CBNumber
- CB53041458
- Molecular Formula
- C22H17FN4O2
- Formula Weight
- 388.39
- MOL File
- 676128-63-5.mol
RSV604 Property
- storage temp.
- Store at -20°C
- solubility
- DMF: 30 mg/ml; DMF:PBS (pH 7.2) (1:20): 0.04 mg/ml; DMSO: 20 mg/ml; Ethanol: 5 mg/ml
- form
- A solid
- color
- White to off-white
N-Bromosuccinimide Price
- Product number
- 29041
- Product name
- RSV-604
- Packaging
- 5mg
- Price
- $100
- Updated
- 2024/03/01
- Product number
- 29041
- Product name
- RSV-604
- Packaging
- 25mg
- Price
- $381
- Updated
- 2024/03/01
- Product number
- 29041
- Product name
- RSV-604
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 29041
- Product name
- RSV-604
- Packaging
- 10mg
- Price
- $184
- Updated
- 2024/03/01
- Product number
- 8549CN
- Product name
- 1-(2-Fluorophenyl)-3-[(3S)-2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepin-3-yl]urea
- Packaging
- 5mg
- Price
- $209
- Updated
- 2021/12/16
RSV604 Chemical Properties,Usage,Production
Biological Activity
RSV604 (A-60444), a novel benzodiazepine, is an inhibitor of respiratory syncytial virus (RSV) with EC50 of 0.86 μM. It has the potential to treat RSV-related diseases. Phase 2.
in vitro
RSV604 (5 days) inhibits the growth of four laboratory strains of RSV (RSS, Long, A2 and B), with EC 50 s ranging from 0.5 to 0.9 μM in plaque reduction assay.
It (6 days) inhibits RSV-induced HEp-2 cell death, with an EC 50 of 0.86 μM.
Also RSV604 (3 days) reduces viral antigen synthesis in RSV-infected HEp-2 cells, with an EC 50 of 1.7 μM.
RSV604 (1-20 μM; 7 days) dose-dependently inhibits RSV infection in human airway epithelial (HAE) cells, with no gross cytotoxicity, leakage of basolateral fluid to the apical surface, or alteration of cilium beat frequency.
target
| Target | Value |
| RSV (Cell-free assay) | 0.86 μM(EC50) |