ChemicalBook > CAS DataBase List > 4-bromo-N'-butylbenzohydrazide

4-bromo-N'-butylbenzohydrazide

Product Name
4-bromo-N'-butylbenzohydrazide
CAS No.
537672-41-6
Chemical Name
4-bromo-N'-butylbenzohydrazide
Synonyms
UF 010;CS-2427;UF010, >98%;UF-010; UF 010;UF010 >=98% (HPLC);4-Bromo-N'-butylbenzohydrazide;4-bromo-N'-butylbenzohydrazide;4-Bromobenzoic acid 2-butylhydrazide;Benzoic acid, 4-bromo-, 2-butylhydrazide;UF010,HDAC,UF-010,UF 010,Histone deacetylases,Inhibitor,inhibit
CBNumber
CB53049247
Molecular Formula
C11H15BrN2O
Formula Weight
271.15
MOL File
537672-41-6.mol
More
Less

4-bromo-N'-butylbenzohydrazide Property

storage temp. 
Sealed in dry,Store in freezer, under -20°C
solubility 
insoluble in H2O; ≥10.65 mg/mL in DMSO; ≥20.85 mg/mL in EtOH
form 
solid
color 
White to off-white
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

More
Less

N-Bromosuccinimide Price

Cayman Chemical
Product number
21273
Product name
UF010
Purity
≥98%
Packaging
5mg
Price
$44
Updated
2024/03/01
Cayman Chemical
Product number
21273
Product name
UF010
Purity
≥98%
Packaging
10mg
Price
$78
Updated
2024/03/01
Cayman Chemical
Product number
21273
Product name
UF010
Purity
≥98%
Packaging
25mg
Price
$172
Updated
2024/03/01
Cayman Chemical
Product number
21273
Product name
UF010
Purity
≥98%
Packaging
50mg
Price
$321
Updated
2024/03/01
TRC
Product number
B680880
Product name
4-Bromo-2-butylhydrazideBenzoicAcid
Packaging
25mg
Price
$165
Updated
2021/12/16
More
Less

4-bromo-N'-butylbenzohydrazide Chemical Properties,Usage,Production

Description

UF010 is a class I HDAC inhibitor with IC50 values of 0.06, 0.1, 0.5, and 1.5 μM for HDAC3, 2, 1, and 8, respectively. It is more than 6-fold selective for these class I HDACs over any additional HDACs. UF010 is reported to inhibit cancer cell proliferation with a mean GI50 value of 2.94 μM when screened against the NCI-60 panel of cancer cell lines and functions by blocking the G1/S phase of the cell cycle.

Uses

4-Bromo-2-butylhydrazide Benzoic Acid inhibits histone deacetylases (HDAC) as potential clinical anticancer therapies.

References

[1]. wang y, stowe rl, pinello ce, et al. identification of histone deacetylase inhibitors with benzoylhydrazide scaffold that selectively inhibit class i histone deacetylases. chem biol, 2015, 22(2): 273-284.

4-bromo-N'-butylbenzohydrazide Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

4-bromo-N'-butylbenzohydrazide Suppliers

China 67 India 1 United Kingdom 1 United States 10 Global 79
Tocris Bioscience
Tel
--
Fax
--
Email
customerservice@tocris.co.uk
Country
United Kingdom
ProdList
5726
Advantage
77

537672-41-6, 4-bromo-N'-butylbenzohydrazideRelated Search:


  • 4-bromo-N'-butylbenzohydrazide
  • UF 010
  • 4-Bromobenzoic acid 2-butylhydrazide
  • CS-2427
  • UF-010; UF 010
  • UF010, >98%
  • Benzoic acid, 4-bromo-, 2-butylhydrazide
  • UF010 >=98% (HPLC)
  • UF010,HDAC,UF-010,UF 010,Histone deacetylases,Inhibitor,inhibit
  • 4-Bromo-N'-butylbenzohydrazide
  • 537672-41-6