DASA-58
- Product Name
- DASA-58
- CAS No.
- 1203494-49-8
- Chemical Name
- DASA-58
- Synonyms
- DASA-58;CS-1563;DASA58; DASA 58;3-[[4-[(2,3-Dihydro-1,4-benzodioxin-6-yl)sulfonyl]hexahydro-1H-1,4-diazepin-1-yl]sulfonyl]benzenamine;Benzenamine, 3-[[4-[(2,3-dihydro-1,4-benzodioxin-6-yl)sulfonyl]hexahydro-1H-1,4-diazepin-1-yl]sulfonyl]-;DASA58,inhibit,Inhibitor,DASA 58,DASA-58,glycolysis,TXNIP,cancer metabolism,Pyruvate Kinase,pyruvate kinase M2,breast cancer,AMPK
- CBNumber
- CB53049409
- Molecular Formula
- C19H23N3O6S2
- Formula Weight
- 453.53
- MOL File
- 1203494-49-8.mol
DASA-58 Property
- Boiling point:
- 681.5±65.0 °C(Predicted)
- Density
- 1.453±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
- solubility
- insoluble in EtOH; insoluble in H2O; ≥127.2 mg/mL in DMSO
- form
- solid
- pka
- 3.35±0.10(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- SML2853
- Product name
- DASA-58
- Purity
- ≥98% (HPLC)
- Packaging
- 5MG
- Price
- $94.2
- Updated
- 2024/03/01
- Product number
- SML2853
- Product name
- DASA-58
- Purity
- ≥98% (HPLC)
- Packaging
- 25MG
- Price
- $306
- Updated
- 2024/03/01
- Product number
- 13941
- Product name
- DASA-58
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $44
- Updated
- 2024/03/01
- Product number
- 13941
- Product name
- DASA-58
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $172
- Updated
- 2024/03/01
- Product number
- 13941
- Product name
- DASA-58
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $321
- Updated
- 2024/03/01
DASA-58 Chemical Properties,Usage,Production
Description
DASA-58 is a selective activator of pyruvate kinase M2 (PKM2; AC50 = 38 nM in vitro, EC50 = 19.6 μM in cells). DASA-58 converts PKM2 to a constitutively active enzyme state that is resistant to inhibition by tyrosine-phosphorylated proteins. Through its effects on PKM2, DASA-58 blocks the induction of HIF-1α by lipopolysaccharide in bone marrow-derived macrophages, suppressing the expression of several HIF-1α-dependent targets, including IL-1β. It also impairs metastatic dissemination of prostate cancer PCa cells in SCID mice.
Definition
ChEBI: 3-[[4-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)-1,4-diazepan-1-yl]sulfonyl]aniline is a member of benzenes and a sulfonamide.
References
[1]. anastasiou d, yu y, israelsen wj, et al. pyruvate kinase m2 activators promote tetramer formation and suppress tumorigenesis. nature chemical biology, 2012, 8(10): 839-847.
DASA-58 Preparation Products And Raw materials
Raw materials
Preparation Products
DASA-58 Suppliers
- Tel
- 021-58955995
- Fax
- 609-228-5909
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- Country
- United States
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- Tel
- +1 (732)236-3202
- sales@cckinase.com
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- United States
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- 58
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- United States
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- Advantage
- 58