PLX7904
- Product Name
- PLX7904
- CAS No.
- 1393465-84-3
- Chemical Name
- PLX7904
- Synonyms
- 5-(2-cyclopropylpyrimidin-5-yl)-3-[3-[[ethyl(methyl)sulfamoyl]amino]-2,6-difluorobenzoyl]-1H-pyrrolo[2,3-b]pyridine;PB04;PB-04;PB 04;PLX7904;PLX 7907;PLX7904(PB04);PLX7904 ，S7964;paradox-breaker-04;PLX7904, 10 mM in DMSO
- CBNumber
- CB53053925
- Molecular Formula
- C24H22F2N6O3S
- Formula Weight
- 512.53
- MOL File
- 1393465-84-3.mol
PLX7904 Property
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- form
- A crystalline solid
- color
- White to light brown
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 20710
- Product name
- PLX7904
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $38
- Updated
- 2024/03/01
- Product number
- 20710
- Product name
- PLX7904
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $166
- Updated
- 2024/03/01
- Product number
- 20710
- Product name
- PLX7904
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $275
- Updated
- 2024/03/01
- Product number
- 20710
- Product name
- PLX7904
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $581
- Updated
- 2023/06/20
- Product number
- 3018EB
- Product name
- CID90116945
- Packaging
- 10mg
- Price
- $403
- Updated
- 2021/12/16
PLX7904 Chemical Properties,Usage,Production
Uses
PLX7904 is a potent and selective BRAF inhibitor, with IC50 of appr 5 nM against BRAFV600E in mutant RAS expressing cells.
Biological Activity
plx7904 is a potent and selective braf inhibitor.oncogenic activation of braf leads to cancer growth by constitutively promoting ras-independent mitogen-activated protein kinase pathway signalling. therefore, braf inhibitors have provided substantially improved treatment of metastatic melanoma.
in vitro
previous study showed that plx7904 could inhibit the in-vitro growth of two melanoma cell lines (a375 and colo829) and an additional human colorectal cancer cell line colo205 expressed brafv600e. the gene expression changes in b9 cells treated with vemurafenib and plx7904 were compared, and results demonstrated that vemurafenib could alter transcription of 191 mouse genes by at least 1.9-fold, while plx7904 had minimal effects. moreover, both vemurafenib and its analogue plx4720 werer able to stimulate b9 colony formation, whereas plx7904 was not [1].
in vivo
animal study showed that both plx7904 and vemurafenib could produce similar anti-tumour effects in a subcutaneous colo205 xenograft model with matching doses at 25 mg/kg twice daily and plasma exposures. in addition, when evaluated in vivo, subcutaneous b9-tumour growth was accelerated by vemurafenib but not by plx7904 when administered at the same dose [1].
IC 50
0.17, 0.53, and 0.16 μm for a375, colo829 and colo205 cell lines, respectively.
References
[1] zhang c et al. raf inhibitors that evade paradoxical mapk pathway activation. nature.2015 oct 22;526(7574):583-6.
PLX7904 Preparation Products And Raw materials
Raw materials
Preparation Products
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