ChemicalBook > CAS DataBase List > PLX7904

PLX7904

Product Name
PLX7904
CAS No.
1393465-84-3
Chemical Name
PLX7904
Synonyms
5-(2-cyclopropylpyrimidin-5-yl)-3-[3-[[ethyl(methyl)sulfamoyl]amino]-2,6-difluorobenzoyl]-1H-pyrrolo[2,3-b]pyridine;PB04;PB-04;PB 04;PLX7904;PLX 7907;PLX7904(PB04);paradox-breaker-04;PLX-7904;PLX 7907;PB04; PB-04; PB 04; PARADOX-BREAKER-04;Sulfamide, N'-[3-[[5-(2-cyclopropyl-5-pyrimidinyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl]-2,4-difluorophenyl]-N-ethyl-N-methyl-
CBNumber
CB53053925
Molecular Formula
C24H22F2N6O3S
Formula Weight
512.53
MOL File
1393465-84-3.mol
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PLX7904 Property

storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
form 
A crystalline solid
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
20710
Product name
PLX7904
Purity
≥98%
Packaging
1mg
Price
$38
Updated
2024/03/01
Cayman Chemical
Product number
20710
Product name
PLX7904
Purity
≥98%
Packaging
5mg
Price
$166
Updated
2024/03/01
Cayman Chemical
Product number
20710
Product name
PLX7904
Purity
≥98%
Packaging
10mg
Price
$275
Updated
2024/03/01
Cayman Chemical
Product number
20710
Product name
PLX7904
Purity
≥98%
Packaging
25mg
Price
$581
Updated
2023/06/20
AK Scientific
Product number
3018EB
Product name
CID90116945
Packaging
10mg
Price
$403
Updated
2021/12/16
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PLX7904 Chemical Properties,Usage,Production

Biological Activity

plx7904 is a potent and selective braf inhibitor.oncogenic activation of braf leads to cancer growth by constitutively promoting ras-independent mitogen-activated protein kinase pathway signalling. therefore, braf inhibitors have provided substantially improved treatment of metastatic melanoma.

in vitro

previous study showed that plx7904 could inhibit the in-vitro growth of two melanoma cell lines (a375 and colo829) and an additional human colorectal cancer cell line colo205 expressed brafv600e. the gene expression changes in b9 cells treated with vemurafenib and plx7904 were compared, and results demonstrated that vemurafenib could alter transcription of 191 mouse genes by at least 1.9-fold, while plx7904 had minimal effects. moreover, both vemurafenib and its analogue plx4720 werer able to stimulate b9 colony formation, whereas plx7904 was not [1].

in vivo

animal study showed that both plx7904 and vemurafenib could produce similar anti-tumour effects in a subcutaneous colo205 xenograft model with matching doses at 25 mg/kg twice daily and plasma exposures. in addition, when evaluated in vivo, subcutaneous b9-tumour growth was accelerated by vemurafenib but not by plx7904 when administered at the same dose [1].

IC 50

0.17, 0.53, and 0.16 μm for a375, colo829 and colo205 cell lines, respectively.

References

[1] zhang c et al. raf inhibitors that evade paradoxical mapk pathway activation. nature.2015 oct 22;526(7574):583-6.

PLX7904 Preparation Products And Raw materials

Raw materials

Preparation Products

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1393465-84-3, PLX7904Related Search:

PLX647 PLX-4720 PLX8394

  • PLX7904
  • 5-(2-cyclopropylpyrimidin-5-yl)-3-[3-[[ethyl(methyl)sulfamoyl]amino]-2,6-difluorobenzoyl]-1H-pyrrolo[2,3-b]pyridine
  • PLX7904(PB04)
  • paradox-breaker-04
  • PB 04
  • PB04
  • PB-04
  • PLX 7907
  • PLX-7904;PLX 7907;PB04; PB-04; PB 04; PARADOX-BREAKER-04
  • Sulfamide, N'-[3-[[5-(2-cyclopropyl-5-pyrimidinyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl]-2,4-difluorophenyl]-N-ethyl-N-methyl-
  • 1393465-84-3
  • C24H22F2N6O3S