ChemicalBook > CAS DataBase List > ST072042
ST072042
- Product Name
- ST072042
- CAS No.
- 88349-90-0
- Chemical Name
- ST072042
- Synonyms
- A2793;ST072042;ethyl 2-(5-chloroquinolin-8-yl)oxyacetate;ethyl [(5-chloroquinolin-8-yl)oxy]acetate;ethyl 2-[(5-chloro-8-quinolyl)oxy]acetate;ethyl 2-(5-chloroquinolin-8-yl)oxyethanoate;2-[(5-chloro-8-quinolyl)oxy]acetic acid ethyl ester;Acetic acid, 2-[(5-chloro-8-quinolinyl)oxy]-, ethyl ester;A2793,inhibit,Inhibitor,A-2793,TALK-1,TRESK,pain,KcsA,TASK-1,A 2793,Potassium Channel
- CBNumber
- CB53056845
- Molecular Formula
- C13H12ClNO3
- Formula Weight
- 265.69
- MOL File
- 88349-90-0.mol
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ST072042 Property
- Boiling point:
- 393.4±27.0 °C(Predicted)
- Density
- 1.291±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO: 100 mg/mL (376.38 mM)
- pka
- 1.97±0.29(Predicted)
- form
- Solid
- color
- White to off-white
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N-Bromosuccinimide Price
ChemScene
- Product number
- CS-0140439
- Product name
- A2793
- Purity
- 99.81%
- Packaging
- 5mg
- Price
- $150
- Updated
- 2021/12/16
Matrix Scientific
- Product number
- 156285
- Product name
- Ethyl [(5-chloroquinolin-8-yl)oxy]acetate
- Packaging
- 0.500g
- Price
- $160
- Updated
- 2021/12/16
Matrix Scientific
- Product number
- 156285
- Product name
- Ethyl [(5-chloroquinolin-8-yl)oxy]acetate
- Packaging
- 1g
- Price
- $200
- Updated
- 2021/12/16
AK Scientific
- Product number
- 8921CZ
- Product name
- Ethyl[(5-chloroquinolin-8-yl)oxy]acetate
- Packaging
- 250mg
- Price
- $248
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0140439
- Product name
- A2793
- Purity
- 99.81%
- Packaging
- 10mg
- Price
- $250
- Updated
- 2021/12/16
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ST072042 Chemical Properties,Usage,Production
Biological Activity
A2793 (Ethyl [(5-Chloroquinolin-8-yl)oxy]acetate) is a TWIK-related spinal cord potassium channel (TRESK, K2P18, KCNK18) and TASK-1 (KCNK3) with IC50 of 6.8 μM for mouse TRESK .
in vitro
A2793 (100 μM) inhibits the unstimulated channel by 43.0±8.9% (n=5) while after ionomycin activation the reduction of the TRESK current is 85.5±2.9% (n=5).
It inhibits TASK-1 (100 μM, 53.4±13,5%, n=5), while A2764 is more selective for TRESK, it only moderately influences TREK-1 and TALK-1.
A2793 may be considered as a tool to discriminate between the resting and activated channels in heterologous expression systems, and to block TRESK activated by calcineurin in the native cells which do not express TASK-1.
target
| Target | Value |
| mTRESK (Cell-free assay) | 6.8 μM |
ST072042 Preparation Products And Raw materials
Raw materials
Preparation Products
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