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ST072042

Product Name
ST072042
CAS No.
88349-90-0
Chemical Name
ST072042
Synonyms
A2793;ST072042;ethyl 2-(5-chloroquinolin-8-yl)oxyacetate;ethyl [(5-chloroquinolin-8-yl)oxy]acetate;ethyl 2-[(5-chloro-8-quinolyl)oxy]acetate;ethyl 2-(5-chloroquinolin-8-yl)oxyethanoate;2-[(5-chloro-8-quinolyl)oxy]acetic acid ethyl ester;Acetic acid, 2-[(5-chloro-8-quinolinyl)oxy]-, ethyl ester;A2793,inhibit,Inhibitor,A-2793,TALK-1,TRESK,pain,KcsA,TASK-1,A 2793,Potassium Channel
CBNumber
CB53056845
Molecular Formula
C13H12ClNO3
Formula Weight
265.69
MOL File
88349-90-0.mol
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ST072042 Property

Boiling point:
393.4±27.0 °C(Predicted)
Density 
1.291±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO: 100 mg/mL (376.38 mM)
pka
1.97±0.29(Predicted)
form 
Solid
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0140439
Product name
A2793
Purity
99.81%
Packaging
5mg
Price
$150
Updated
2021/12/16
Matrix Scientific
Product number
156285
Product name
Ethyl [(5-chloroquinolin-8-yl)oxy]acetate
Packaging
0.500g
Price
$160
Updated
2021/12/16
Matrix Scientific
Product number
156285
Product name
Ethyl [(5-chloroquinolin-8-yl)oxy]acetate
Packaging
1g
Price
$200
Updated
2021/12/16
AK Scientific
Product number
8921CZ
Product name
Ethyl[(5-chloroquinolin-8-yl)oxy]acetate
Packaging
250mg
Price
$248
Updated
2021/12/16
ChemScene
Product number
CS-0140439
Product name
A2793
Purity
99.81%
Packaging
10mg
Price
$250
Updated
2021/12/16
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ST072042 Chemical Properties,Usage,Production

Biological Activity

A2793 (Ethyl [(5-Chloroquinolin-8-yl)oxy]acetate) is a TWIK-related spinal cord potassium channel (TRESK, K2P18, KCNK18) and TASK-1 (KCNK3) with IC50 of 6.8 μM for mouse TRESK .

in vitro

A2793 (100 μM) inhibits the unstimulated channel by 43.0±8.9% (n=5) while after ionomycin activation the reduction of the TRESK current is 85.5±2.9% (n=5).
It inhibits TASK-1 (100 μM, 53.4±13,5%, n=5), while A2764 is more selective for TRESK, it only moderately influences TREK-1 and TALK-1.
A2793 may be considered as a tool to discriminate between the resting and activated channels in heterologous expression systems, and to block TRESK activated by calcineurin in the native cells which do not express TASK-1.

target

TargetValue
mTRESK
(Cell-free assay)
6.8 μM

ST072042 Preparation Products And Raw materials

Raw materials

Preparation Products

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ST072042 Suppliers

Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696,15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4566
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55
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9806
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58
Tianjin Kailiqi Biotechnology Co., Ltd.
Tel
15076683720
Fax
022-23754520
Email
klq@cw-bio.com
Country
China
ProdList
4963
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55
ShangHai Biochempartner Co.,Ltd
Tel
177-54423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
8012
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Yantai ShengKailun Chemical Technology Co., Ltd.
Tel
13356901049
Fax
QQ:1025383091
Email
3119594100@qq.com
Country
China
ProdList
7964
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55
Zhengzhou Alfa Chemical Co.,Ltd
Tel
+8618530059196
Email
sale04@alfachem.cn
Country
China
ProdList
11817
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58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32161
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InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
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DC Chemicals
Tel
021-58447131 13564518121
Email
sales@dcchemicals.com
Country
China
ProdList
9409
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58
Changzhou Chenhong Biotechnology Co., Ltd.
Tel
0519-85788828 13775037613
Email
sales@chemrenpharm.com
Country
China
ProdList
3600
Advantage
58

88349-90-0, ST072042Related Search:


  • 2-[(5-chloro-8-quinolyl)oxy]acetic acid ethyl ester
  • ethyl [(5-chloroquinolin-8-yl)oxy]acetate
  • ethyl 2-(5-chloroquinolin-8-yl)oxyacetate
  • ethyl 2-(5-chloroquinolin-8-yl)oxyethanoate
  • ethyl 2-[(5-chloro-8-quinolyl)oxy]acetate
  • ST072042
  • A2793
  • Acetic acid, 2-[(5-chloro-8-quinolinyl)oxy]-, ethyl ester
  • A2793,inhibit,Inhibitor,A-2793,TALK-1,TRESK,pain,KcsA,TASK-1,A 2793,Potassium Channel
  • 88349-90-0