XEN907

Product Name: XEN907
CAS No.: 912656-34-9
Chemical Name: XEN907
Synonyms: XEN907;XEN907,XEN-907;XEN907, 10 mM in DMSO;XEN907; XEN 907; XEN-907;1'-pentylspiro[6H-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one;1-Pentyl-6'H-spiro[indoline-3,7'-[1,3]dioxolo[4,5-f]benzofuran]-2-one;1-Pentyl-6'H-spiro[indoline-3,7'-[1,3]dioxolo[4,5-f]benzofuran]-2-one;Spiro[furo[2,3-f]-1,3-benzodioxole-7(6H),3'-[3H]indol]-2'(1'H)-one, 1'-pentyl-;1-CYCLOPENTYL-1,2-DIHYDRO-6',10',12'-TRIOXASPIRO[INDOLE-3,4'-TRICYCLO[7.3.0.0^{3,7}]DODECANE]-1',3'(7'),8'-TRIEN-2-ONE
CBNumber: CB53060912
Molecular Formula: C21H21NO4
Formula Weight: 351.4
MOL File: 912656-34-9.mol

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XEN907 Property

Melting point:: 88-90 °C
Boiling point:: 566.9±50.0 °C(Predicted)
Density: 1.34±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in DMSO
pka: -0.19±0.20(Predicted)
form: Solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-5482
Product name: XEN907
Purity: 99.55%
Packaging: 5mg
Price: $150
Updated: 2021/12/16

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XEN907 Chemical Properties,Usage,Production

Description

XEN907 is a novel spirooxindole NaV1.7 blocker with IC50 of 3 nM. It shows a further 10-fold increase in potency, which represents a promising structure for further optimization efforts in vitro.

Uses

XEN907 is a potent and spirooxindole blocker of NaV1.7, with an IC50 of 3 nM. XEN907 also inhibits CYP3A4 in a recombinant human enzyme assay. XEN907 can be used for the research of pain[1][2].

in vivo

XEN907 (10 mg/kg; p.o.) exhibits moderate oral bioavailability (13 %), C_max (35 ng/mL), and AUC_last (143 h?ng/mL) in rats^[1].
XEN907 (3 mg/kg; i.v.) exhibits terminal elimination half-life (2.6 h), high plasma clearance (9.4 L/h/kg), and large volumes of distribution (35.0 L/kg) in rats^[1].

IC 50

Nav1.7

References

[1] Chowdhury S, et al. Discovery of XEN907, a spirooxindole blocker of NaV1.7 for the treatment of pain. Bioorg Med Chem Lett. 2011 Jun 15;21(12):3676-81. DOI:10.1016/j.bmcl.2011.04.088
[2] Chowdhury S, et, al. Tetracyclic spirooxindole blockers of hNaV1.7: activity in vitro and in CFA-induced inflammatory pain model. Med Chem Res (2013) 22:1825–1836.

XEN907 Preparation Products And Raw materials

Raw materials

Preparation Products

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XEN907 Suppliers

China 31 United States 3 Global 34

WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd.

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MedChemexpress LLC

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HangZhou YuHao Chemical Technology Co., Ltd.

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Musechem

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Wuhan Sun-shine Bio-technology Corporation Limited

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Jinan Yaoyan Pharmaceutical Co., Ltd.

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Fan De(Beijing) Biotechnology Co., Ltd.

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Nanjing Meihao Pharmaceutical Technology Co., Ltd.

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912656-34-9, XEN907Related Search:

10,10-BIS(4-PYRIDINYLMETHYL)-9(10H)-ANTHRACENONE DIHYDROCHLORIDE XENOLIGHT D-LUCIFERIN POTASSIUM SALT

XEN907

1-CYCLOPENTYL-1,2-DIHYDRO-6',10',12'-TRIOXASPIRO[INDOLE-3,4'-TRICYCLO[7.3.0.0^{3,7}]DODECANE]-1',3'(7'),8'-TRIEN-2-ONE

XEN907; XEN 907; XEN-907

Spiro[furo[2,3-f]-1,3-benzodioxole-7(6H),3'-[3H]indol]-2'(1'H)-one, 1'-pentyl-

1'-pentylspiro[6H-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one

XEN907,XEN-907

1-Pentyl-6'H-spiro[indoline-3,7'-[1,3]dioxolo[4,5-f]benzofuran]-2-one

XEN907, 10 mM in DMSO

1-Pentyl-6'H-spiro[indoline-3,7'-[1,3]dioxolo[4,5-f]benzofuran]-2-one

912656-34-9