Azido-PEG3-aldehyde

Product Name: Azido-PEG3-aldehyde
CAS No.: 1807530-10-4
Chemical Name: Azido-PEG3-aldehyde
Synonyms: N3-PEG3-CHO;N3-PEG3-ALD;N3-PEG3-CH2CH2CHO;Azido-PEG3-aldehyde;3-[2-[2-(2-Azidoethoxy)ethoxy]ethoxy]propanal
CBNumber: CB53062350
Molecular Formula: C9H17N3O4
Formula Weight: 231.25
MOL File: 1807530-10-4.mol

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Azido-PEG3-aldehyde Property

form: Liquid
color: Colorless to off-white

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Hazard and Precautionary Statements (GHS)

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Azido-PEG3-aldehyde Chemical Properties,Usage,Production

Uses

Azido-PEG3-aldehyde is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG3-aldehyde is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

Biological Activity

Azido-PEG3-aldehyde is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

IC 50

PEGs

References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Azido-PEG3-aldehyde Preparation Products And Raw materials

Raw materials

Preparation Products

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1807530-10-4, Azido-PEG3-aldehydeRelated Search:

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Azido-PEG3-aldehyde

N3-PEG3-ALD

N3-PEG3-CHO

N3-PEG3-CH2CH2CHO

3-[2-[2-(2-Azidoethoxy)ethoxy]ethoxy]propanal

1807530-10-4