Naquotinib
- Product Name
- Naquotinib
- CAS No.
- 1448232-80-1
- Chemical Name
- Naquotinib
- Synonyms
- ASP-8273;Naquotinib;Naquotinib,ASP-8273;NAQUOTINIB (FREE BASE);Epidermal growth factor receptor,EGFR,ASP 8273,HER1,ErbB-1,ASP-8273,inhibit,Naquotinib,Inhibitor;(R)-5-((1-acryloylpyrrolidin-3-yl)oxy)-6-ethyl-3-((4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)amino)pyrazine-2-carboxamide;6-Ethyl-3-[[4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]amino]-5-[[(3R)-1-(1-oxo-2-propen-1-yl)-3-pyrrolidinyl]oxy]-2-pyrazinecarboxamide;2-Pyrazinecarboxamide, 6-ethyl-3-[[4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]amino]-5-[[(3R)-1-(1-oxo-2-propen-1-yl)-3-pyrrolidinyl]oxy]-
- CBNumber
- CB53062789
- Molecular Formula
- C30H42N8O3
- Formula Weight
- 562.71
- MOL File
- 1448232-80-1.mol
Naquotinib Property
- Boiling point:
- 717.6±60.0 °C(Predicted)
- Density
- 1.248±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMF: 30mg/ml; DMSO: 2 mg/ml; Ethanol: 30mg/ml
- form
- A crystalline solid
- pka
- 14.10±0.50(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 23498
- Product name
- Naquotinib
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $44
- Updated
- 2024/03/01
- Product number
- 23498
- Product name
- Naquotinib
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $151
- Updated
- 2024/03/01
- Product number
- 23498
- Product name
- Naquotinib
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $278
- Updated
- 2024/03/01
- Product number
- N378710
- Product name
- Naquotinib
- Packaging
- 1mg
- Price
- $80
- Updated
- 2021/12/16
- Product number
- orb611431
- Product name
- Naquotinib
- Packaging
- 5mg
- Price
- $569.5
- Updated
- 2021/12/16
Naquotinib Chemical Properties,Usage,Production
Uses
Naquotinib is an epidermal growth factor receptor (EGFR) inhibitor.
Biological Activity
Naquotinib (ASP8273) is an orally active, irreversible, mutant-selective epidermal growth factor receptor (EGFR) inhibitor with potential antitumor activity.
in vitro
ASP8273 is an irreversible TKI small molecule inhibitor that inhibits the kinase activity of EGFR mutants including T97M with limited activity against wild-type EGFR. In in vitro enzymatic activity and cellular assays, ASP8273 covalently bound to an EGFR mutant (L858R/T790M) through cysteine residues and long-term inhibited EGFR phosphorylation for 24 hours. In NSCLC cell lines with the above-mentioned EGFR mutations, ASP8273 has IC50 values in the range of 8-33 nM for EGFR mutants, more potent than WT EGFR (IC50 for WT EGFR is 230 nM).
target
| Target | Value |
| mutant EGFR |
Naquotinib Preparation Products And Raw materials
Raw materials
Preparation Products
Naquotinib Suppliers
- Tel
- 021-58955995
- Fax
- 609-228-5909
- sales@medchemexpress.cn
- Country
- United States
- ProdList
- 4863
- Advantage
- 58
- Tel
- +1-800-259-7612
- Fax
- +1-800-259-7612
- info@musechem.com
- Country
- United States
- ProdList
- 4662
- Advantage
- 60
- Tel
- +1-631-485-4226
- Fax
- 1-631-614-7828
- inquiry@bocsci.com
- Country
- United States
- ProdList
- 19553
- Advantage
- 58
- Tel
- +1-+1(833)-552-7181
- sales@aladdinsci.com
- Country
- United States
- ProdList
- 57511
- Advantage
- 58